A5036084171- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Gastrointestinal motility and disorders
- Child Nutrition and Feeding Issues
- Pharmaceutical studies and practices
- Clinical Nutrition and Gastroenterology
- Obesity, Physical Activity, Diet
- Vitamin D Research Studies
- Child Nutrition and Water Access
- Breastfeeding Practices and Influences
- Electrolyte and hormonal disorders
- Pregnancy and preeclampsia studies
- Congenital Diaphragmatic Hernia Studies
- Diet and metabolism studies
- Hip and Femur Fractures
- Nuclear Structure and Function
- Acupuncture Treatment Research Studies
- Pain Management and Placebo Effect
- Retinoids in leukemia and cellular processes
- Ubiquitin and proteasome pathways
- Neonatal Respiratory Health Research
- Complementary and Alternative Medicine Studies
- Intestinal Malrotation and Obstruction Disorders
- Congenital Heart Disease Studies
- Pregnancy and Medication Impact
Takeda (United States)
2020-2024
Harvard University
2005-2024
Ironwood Pharmaceuticals (United States)
2023-2024
Boston Children's Hospital
2013-2024
Pediatrics and Genetics
2017
Boston Children's Museum
2006-2016
Brigham and Women's Hospital
2012-2016
Beth Israel Deaconess Medical Center
2014-2016
Boston University
2004-2016
Brown University
2016
Pediatric feeding disorders (PFDs) lack a universally accepted definition. Feeding require comprehensive assessment and treatment of 4 closely related, complementary domains (medical, psychosocial, skill-based systems associated nutritional complications). Previous diagnostic paradigms have, however, typically defined using the lens single professional discipline fail to characterize functional limitations that are critical plan appropriate interventions improve quality life. Using framework...
Hutchinson–Gilford progeria syndrome (HGPS) is an extremely rare, fatal, segmental premature aging caused by a mutation in LMNA that produces the farnesylated aberrant lamin A protein, progerin. This multisystem disorder causes failure to thrive and accelerated atherosclerosis leading early death. Farnesyltransferase inhibitors have ameliorated disease phenotypes preclinical studies. Twenty-five patients with HGPS received farnesyltransferase inhibitor lonafarnib for minimum of 2 y. Primary...
To examine the association between timing of introduction solid foods during infancy and obesity at 3 years age.We studied 847 children in Project Viva, a prospective pre-birth cohort study. The primary outcome was age (BMI for gender ≥ 95th percentile). exposure foods, categorized as <4, 4 to 5, 6 months. We ran separate logistic regression models infants who were breastfed least months ("breastfed") never or stopped breastfeeding before four ("formula-fed"), adjusting child maternal...
We established Project Viva to examine prenatal diet and other factors in relation maternal child health. recruited pregnant women at their initial visit eastern Massachusetts between 1999 2002. Exclusion criteria included multiple gestation, inability answer questions English, gestational age ≥22 weeks recruitment plans move away before delivery. completed in-person visits with mothers during pregnancy the late first (median 9.9 of gestation) second 27.9 weeks) trimesters. saw children...
To examine whether delivery by caesarean section is a risk factor for childhood obesity.Prospective prebirth cohort study (Project Viva).Eight outpatient multi-specialty practices based in the Boston, Massachusetts area.We recruited women during early pregnancy between 1999 and 2002, followed their children after birth. We included 1255 with body composition measured at 3 years of age.BMI score, obesity (BMI age sex ≥95th percentile), sum triceps plus subscapular skinfold thicknesses age.284...
Abstract Objective : To examine the extent to which maternal prenatal smoking is associated with adiposity, central and blood pressure in 3‐year‐old children. Research Methods Procedures We studied 746 mother‐child pairs Project Viva, a prospective cohort study, categorized mothers as never, early pregnancy, or former smokers. Main outcome measures were overweight (BMI for age sex > 85th percentile), BMI z‐score, sum of subscapular (SS) triceps (TR) skinfolds, SS:TR skinfold ratio,...
Hutchinson-Gilford progeria syndrome is an extremely rare, fatal, segmental premature aging caused by a mutation in LMNA yielding the farnesylated aberrant protein progerin. Without progerin-specific treatment, death occurs at average age of 14.6 years from accelerated atherosclerosis. A previous single-arm clinical trial demonstrated that farnesyltransferase inhibitor lonafarnib ameliorates some aspects cardiovascular and bone disease. This present sought to further improve disease...
Although gastroparesis carries a considerable health care and patient burden, associated epidemiological data are limited. To provide new real-world evidence for gastroparesis, we estimated disease prevalence, investigated demographics etiology in large US claims database.This retrospective, cross-sectional analysis used de-identified, longitudinal patient-level enrollment billing adults from the Optum Clinformatics Data Mart database, national administrative insurance database. Prevalence...
Abstract Hutchinson-Gilford progeria syndrome (HGPS) is a rare segmental premature aging disorder that affects bone and body composition, among other tissues. We sought to determine whether density structural geometry are altered in children with HGPS relationships exist these parameters measures of skeletal anthropometry, nutrition. prospectively enrolled 26 (ages 3.1 16.2 years). Outcomes included anthropometric data; age; areal mineral (aBMD) composition by dual-energy X-ray...
To describe the prevalence and clinical characteristics of transient hyperphosphatasemia (TH) in a cohort healthy infants toddlers.We performed secondary data analysis toddlers enrolled study examining epidemiology vitamin D deficiency. From 2005 to 2007, children aged 8 24 months were during well-child visits at an urban primary care pediatric clinic. At enrollment, we collected regarding sociodemographic characteristics. We measured serum levels alkaline phosphatase (AP), 25-hydroxyvitamin...
Abstract Objective: Animal models suggest that fetal exposure to glucocorticoids can program adiposity, especially central later in life. We examined associations of maternal corticotropin‐releasing hormone (CRH) levels the late 2nd trimester pregnancy, a marker glucocorticoid exposure, with child adiposity at age 3 years. Research Methods and Procedures: analyzed data from 199 participants Project Viva, prospective cohort study pregnant women their children, At years, main outcomes were...
Animal data show that decreased activity of placental 11-beta-hydroxysteroid dehydrogenase type 2 (11β-HSD2), which potently inactivates glucocorticoids (e.g. cortisol) to inert forms (cortisone), allows increased access maternal the fetus and 'programs' hypertension. Data in humans are limited. We examined association between venous umbilical cord blood glucocorticoids, a potential marker for 11β-HSD2 enzyme activity, pressure at age 3 years. Among 286 newborns Project Viva, prospective...
Background The major threat to the long-term survival of cardiac allograft recipients is development diffuse intimal thickening in coronary arteries through mechanisms that are poorly understood. Although antidonor antibodies have been associated with this condition, a causal relationship has not established. Methods and Results To determine whether humoral immune responses necessary for graft vascular disease, we performed abdominal aortic allografts from normal donor mice into different...
Abstract Background Due to limited treatment options, many patients with diabetic gastroparesis (DG) or idiopathic (IG) experience inadequate symptom control resulting in increased health‐care resource utilization (HRU) and associated costs. We compared all‐cause HRU costs over the 3 years after patients’ first diagnosis that of matched controls without gastroparesis. Methods Newly diagnosed adults DG IG were identified Optum's de‐identified Clinformatics ® Data Mart Database (Q1‐2007...
Previous clinical studies of trazpiroben, a dopamine D2 /D3 receptor antagonist for long-term treatment moderate-to-severe idiopathic and diabetic gastroparesis, have shown improved symptoms fullness. This study assessed trazpiroben efficacy, safety, tolerability in adults with gastroparesis versus placebo.This global, multicenter, double-blind, parallel-group, phase 2b (NCT03544229) enrolled eligible aged 18-85 years symptomatic or gastroparesis. Randomized participants received either oral...
Background Animal data show that low protein intake in pregnancy programs higher offspring blood pressure, but similar humans are limited. We examined the associations of first and second trimester maternal with pressure (BP) at age six months.