A5024669314- Ethics in medical practice
- Palliative Care and End-of-Life Issues
- Biomedical Ethics and Regulation
- Ethics in Clinical Research
- Ethics and Legal Issues in Pediatric Healthcare
- Esophageal and GI Pathology
- Patient Dignity and Privacy
- Genomics and Rare Diseases
- Neurogenetic and Muscular Disorders Research
- Gastrointestinal disorders and treatments
- Metastasis and carcinoma case studies
- Intestinal and Peritoneal Adhesions
- Gallbladder and Bile Duct Disorders
- Dysphagia Assessment and Management
- Biliary and Gastrointestinal Fistulas
- Gastric Cancer Management and Outcomes
- Abdominal Surgery and Complications
- Mental Health and Psychiatry
- Gastroesophageal reflux and treatments
- Pluripotent Stem Cells Research
- Ureteral procedures and complications
- Geriatric Care and Nursing Homes
- Airway Management and Intubation Techniques
- Childhood Cancer Survivors' Quality of Life
- Helicobacter pylori-related gastroenterology studies
Newcastle University
2014-2023
Wirral University Teaching Hospital NHS Foundation Trust
2019-2021
Royal Marsden NHS Foundation Trust
2020
Cabrini Hospital
1993-2019
Muscular Dystrophy UK
2016
University of Newcastle Australia
2004-2016
Princess Margaret Hospital for Children
2010
Monash University
1986-2007
The Alfred Hospital
1986-2004
Royal Victoria Hospital
2004
This is the second half of a two-part document updating standard care recommendations for spinal muscular atrophy published in 2007. part includes updated on pulmonary management and acute issues, topics that have emerged last few years such as other organ involvement severe forms role medications. Ethical issues choice palliative versus supportive are also addressed. These becoming increasingly relevant given recent clinical trials prospect commercially available therapies will likely...
Objective The authors determined if more radical surgery with extended lymphadenectomy improves the results of gastrectomy in patients adenocarcinoma gastric antrum. Summary Background Data overall survival cancer is disappointing. Improved has been reported by Japanese authors. Whether this because a higher number early cancers series, different biologic behavior Asians, or adoption remains unclear. Methods R1 subtotal omentectomy and R3 total (omentectomy, splenectomy, distal...
Determine whether absorbable or nonabsorbable mesh in repair of large hiatus hernias reduces the risk recurrence, compared with suture repair.Repair hernia is associated radiological recurrence rates up to 30%, and improve outcomes has been recommended. Previous trials have shown less short-term mesh, but adverse limit use.Multicentre prospective double blind randomized controlled trial 3 methods repair: sutures versus mesh. Primary outcome-hernia assessed by barium meal radiology endoscopy...
There is a growing international agreement on the need to provide greater access research data and bio-specimen collections optimize their long-term value exploit potential for health discovery validation. This especially evident rare disease research. Currently, rising of does not correspond with an equal increase in data/sample-sharing data/sample access. Contradictory legal ethical frameworks across national borders are obstacles effective sharing: more specifically, absence integrated...
Objective: To determine whether absorbable or nonabsorbable mesh repair of large hiatus hernias is followed by less recurrences at late follow-up compared to sutured repair. Summary Background Data: Radiological have been reported in up 30% patients after hernias, and has proposed as a solution. Earlier trials revealed mixed outcomes early from trial previously no short-term advantages for Methods: Multicentre prospective double-blind randomized controlled 3 methods hernia repair; sutures...
There is a growing concern in the ethics literature and among policy makers that de-identification or coding of personal data biospecimens not sufficient for protecting research subjects from privacy invasions possible breaches confidentiality due to possibility unauthorized re-identification. At same time, there need medical science be able identify individual patients. In particular rare disease special well-documented collaboration so biosamples multiple independent studies can shared...
The increased international sharing of data in research consortia and the introduction new technologies for sequencing challenge informed consent (IC) process, adding complexities that require coordination between centres worldwide. Rare disease present special challenges since available samples may be very limited. Thus, it is especially relevant to ensure best use resources but at same time protect patients' right integrity. To achieve this aim, there an ethical duty plan advance possible...
This article explores some of the pertinent issues that arose while conducting a research study involving people with terminal illness, their lay carers and bereaved carers. Ethical considerations are paramount importance when carrying out vulnerable groups; such as approaching potential participants without adding to distress anxiety, obtaining consent coercion need careful consideration. Adhering stringent design, preferable for agenda, is not always compatible ethical concepts beneficence...
ABSTRACT In this paper we argue that the consensus around normative standards for ethics of research in clinical trials, strongly influenced by Declaration Helsinki, is perceived from various quarters as too conservative and potentially restrictive seen urgent necessary. We examine problem perspective challengers who alternative approaches to what ought or not be permitted. Key themes within analysis will these claims they have implications interests subject, governance regulation. Using our...
Background : This study arose out of concern about the transmission infectious diseases through eye splash injuries in surgery. The purpose this was to identify extent risk injuries. Methods A prospective trial undertaken which examined 160 consecutive shields used by surgeons and assistants operations 30 min or longer. were inspected for macroscopic splashes then tested microscopic using reagent strips. Results Of surgery, 71 positive blood (44%). surgeon aware spray episode only 13 cases...
Abstract A retrospective study of patients having gastroenterostomies was undertaken to identify predictive factors for the development postoperative delayed return gastric emptying (DRGE). total 322 consecutive underwent 324 gastroenterostomies; 35 experienced emptying. Regression analysis demonstrated preoperative obstruction be most significant factor (P < 0·001). Vagotomy not an independent variable. Age, sex, size stoma, anastomotic technique, albumin and experience operator were...
Abstract “Full-stack” biotechnology platforms for cell line (re)programming are on the horizon, thanks mostly to (a) advances in gene synthesis and editing techniques as well (b) growing integration of life science research with informatics, internet things automation. These emerging will accelerate production consumption biological products. Hence, traceability, transparency, and—ultimately—trustworthiness is required from cradle grave engineered lines their engineering processes. Here we...
Drug trials in children engage with many ethical issues, from drug-related safety concerns to communication patients and parents, recruitment informed consent procedures.This paper addresses the field of neuromuscular disorders where possibility genetic, mutation-specific treatments, has added new complexity.Not only must trial design address issues equity access, but researchers also think through implications adopting a personalised medicine approach, which requires precise molecular...
The World Health Organization (1990) provides guidelines on what constitutes effective palliative care. However, it remains unclear whether people with a terminal illness living in their own homes have access to the services they need. This article reports study carried out United Kingdom views of (n=15), lay carers (n=10) and bereaved (n=19). Participants were asked about primary care had received both helpful unhelpful aspects service provision. All terminally ill (except one) cancer,...