A5067248419- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Diabetes Management and Research
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Diabetes and associated disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- Lipoproteins and Cardiovascular Health
- Diet and metabolism studies
- Endoplasmic Reticulum Stress and Disease
- Cancer, Lipids, and Metabolism
- Protein Kinase Regulation and GTPase Signaling
- Advanced Glycation End Products research
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Heat shock proteins research
- Pharmacology and Obesity Treatment
- Adrenal and Paraganglionic Tumors
- Regulation of Appetite and Obesity
- Pituitary Gland Disorders and Treatments
- Inflammatory mediators and NSAID effects
Kumamoto University
2016-2025
Kumamoto Health Science University
2019-2025
Japan Hospital Association
2023-2025
Kumamoto University Hospital
2012-2022
Chiba University
1996-2019
Okayama University
2019
Niigata University
2019
Weatherford College
2019
Kanazawa University
2007-2019
Nagasaki University
2019
Concept of Diabetes Mellitus: mellitus is a group diseases associated with various metabolic disorders, the main feature which chronic hyperglycemia due to insufficient insulin action. Its pathogenesis involves both genetic and environmental factors. The long-term persistence disorders can cause susceptibility specific complications also foster arteriosclerosis. broad range clinical presentations, from being asymptomatic ketoacidosis or coma, depending on degree disorder. Classification...
Overload of pancreatic β cells in conditions such as hyperglycemia, obesity, and long-term treatment with sulfonylureas leads to cell exhaustion type 2 diabetes. Because mass declines under these conditions, apparently a result apoptosis, we speculated that overload kills endoplasmic reticulum (ER) stress. The Akita mouse, which carries conformation-altering missense mutation (Cys96Tyr) Insulin 2, likewise exhibits hyperglycemia reduced mass. In the development diabetes mice, mRNAs for ER...
In 1999, the Japan Diabetes Society (JDS) launched previous version of diagnostic criteria diabetes mellitus, in which JDS took initiative adopting glycated hemoglobin (HbA1c) as an adjunct to diagnosis diabetes. contrast, 2009 International Expert Committee composed members American Association (ADA) and European for Study (EASD) manifested recommendation regarding use HbA1c diagnosing mellitus alternative glucose measurements based on updated evidence showing that has several advantages a...
Overload of pancreatic β cells in conditions such as hyperglycemia, obesity, and long-term treatment with sulfonylureas leads to cell exhaustion type 2 diabetes. Because mass declines under these conditions, apparently a result apoptosis, we speculated that overload kills endoplasmic reticulum (ER) stress. The Akita mouse, which carries conformation-altering missense mutation (Cys96Tyr) Insulin 2, likewise exhibits hyperglycemia reduced mass. In the development diabetes mice, mRNAs for ER...
Excessive nitric oxide (NO) production in cytokine-activated β cells has been implicated cell disruption type 1 diabetes. are very vulnerable to NO-induced apoptosis. However, the mechanism underlying this phenomenon is unclear. Low concentrations of NO that lead apoptosis apparently do not cause severe DNA damage mouse MIN6 cells. CHOP, a C/EBP homologous protein induced by endoplasmic reticulum (ER) stress and plays role growth arrest death, was donor, S -nitroso- N -acetyl- d,l...
We previously proposed that the production of hyperglycemia-induced mitochondrial reactive oxygen species (mtROS) is a key event in development diabetes complications. The association between pathogenesis and its complications biogenesis has been recently reported. Because metformin reported to exert possible additional benefit preventing complications, we investigated effect 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) on mtROS cultured human umbilical vein endothelial cells....
Cyclooxygenase-2 (COX-2), a prostanoid-synthesizing enzyme that contributes to the toxicity associated with inflammation, has recently emerged as promising therapeutic target for several illnesses, ranging from osteoarthritis Alzheimer's disease. Although COX-2 also been linked ischemic stroke, its role in mechanisms of brain injury remains controversial. We demonstrate COX-2-deficient mice have significant reduction produced by occlusion middle cerebral artery. The protection can be...
To test whether the tyrosine kinase activity of insulin receptor is crucial for action, we have constructed mutations human at Lys-1030, which in presumed ATP-binding region. By using oligonucleotide-directed mutagenesis, this lysine residue was replaced with either methionine, arginine, or alanine. Chinese hamster ovary cells were transfected by mutant cDNAs and expressed receptors characterized. We show here that none these mutants exhibited insulin-activated autophosphorylation vitro....
Combination therapy with insulin and glucagon-like peptide-1 receptor agonists (GLP-1RAs) is important for treating type 2 diabetes (T2D). This trial assesses the efficacy safety of semaglutide, a GLP-1RA, as an add-on to basal insulin. To demonstrate superiority semaglutide vs placebo on glycemic control in patients T2D. Phase 3a, double-blind, placebo-controlled, 30-week trial. study included 90 sites five countries. We studied 397 uncontrolled T2D receiving stable or without metformin....
The current guideline represents the 6th edition of 'Japanese Clinical Practice Guideline for Diabetes' which has been revised every three years since its first appearance in 2004 to promote evidence-based, rational, efficient and consistent clinical practice diabetes. Of note, dramatic progress made recent diabetes research practice, includes approval antidiabetic agents with novel mechanisms action along publication trial results these drugs, diagnostic therapeutic devices, such as...
OBJECTIVE This 24-week, double-blinded, phase 3 clinical trial (DEPICT-2; ClinicalTrials.gov, NCT02460978) evaluated efficacy and safety of dapagliflozin as adjunct therapy to adjustable insulin in patients with inadequately controlled type 1 diabetes (HbA1c 7.5–10.5%). RESEARCH DESIGN AND METHODS Patients were randomized 1:1:1 5 mg (n = 271), 10 270), or placebo 272) plus insulin. Insulin dose was adjusted by investigators according self-monitored glucose readings, local guidance,...
OBJECTIVE To investigate the efficacy, safety, and tolerability of oral semaglutide added to insulin with or without metformin. RESEARCH DESIGN AND METHODS Patients type 2 diabetes uncontrolled on metformin were randomized 3 mg (N = 184), 7 182), 14 181) placebo 184) in a 52-week, double-blind trial. End points change from baseline week 26 HbA1c (primary) body weight (confirmatory secondary). Two estimands defined: treatment policy (effect regardless trial product discontinuation rescue...
In recent years, several oral antidiabetic drugs with new mechanisms of action have become available, expanding the number treatment options. Sodium/glucose cotransporter-2 (SGLT2) inhibitors are a class an insulin-independent mechanism promoting urinary glucose excretion. We report results combined Phase 2 and 3 clinical study (Japic CTI-101349) SGLT2 inhibitor tofogliflozin (CSG452, RG7201) in Japanese patients type diabetes mellitus. The efficacy safety were assessed this multicenter,...