A5047672240- Solid-state spectroscopy and crystallography
- Spectroscopy and Quantum Chemical Studies
- Semiconductor Quantum Structures and Devices
- Flowering Plant Growth and Cultivation
- Advanced Frequency and Time Standards
- Nonlinear Optical Materials Research
- Plant tissue culture and regeneration
- Landslides and related hazards
- Quantum Dots Synthesis And Properties
- Quantum Information and Cryptography
- Plant Physiology and Cultivation Studies
- Semiconductor Lasers and Optical Devices
- Epigenetics and DNA Methylation
- Hemoglobinopathies and Related Disorders
- Chalcogenide Semiconductor Thin Films
- Cold Atom Physics and Bose-Einstein Condensates
- Automotive and Human Injury Biomechanics
- Scientific Measurement and Uncertainty Evaluation
- Photonic and Optical Devices
- RNA modifications and cancer
- Transportation Safety and Impact Analysis
- Vehicle Dynamics and Control Systems
- Metal Forming Simulation Techniques
- Coastal wetland ecosystem dynamics
- Food Safety and Hygiene
Tokyo University of Agriculture and Technology
2006-2025
Tohoku University
2013-2024
Tohoku Medical Megabank Organization
2023-2024
Honda (Japan)
2023
Hokkaido University
1992-2022
Railway Technical Research Institute
2008-2022
Nihon University
2004-2022
Funabashi Orthopaedic Hospital
2022
Nara Medical University Hospital
2021
Orthopaedic Hospital
2021
OBJECTIVE This 24-week, double-blinded, phase 3 clinical trial (DEPICT-2; ClinicalTrials.gov, NCT02460978) evaluated efficacy and safety of dapagliflozin as adjunct therapy to adjustable insulin in patients with inadequately controlled type 1 diabetes (HbA1c 7.5–10.5%). RESEARCH DESIGN AND METHODS Patients were randomized 1:1:1 5 mg (n = 271), 10 270), or placebo 272) plus insulin. Insulin dose was adjusted by investigators according self-monitored glucose readings, local guidance,...
Animal models of Down syndrome (DS), trisomic for human chromosome 21 (HSA21) genes or orthologs, provide insights into better understanding and treatment options. The only existing transchromosomic (Tc) mouse DS model, Tc1, carries a HSA21 with over 50 protein coding (PCGs) disrupted. Tc1 is mosaic, compromising interpretation results. Here, we “clone” the 34 MB long arm (HSA21q) as artificial (MAC). Through multiple steps microcell-mediated transfer, created new Tc Tc(HSA21q;MAC)1Yakaz...
The synthesis of a Pt- and Pd-nanoparticle-dispersed polyimide film as precursor for the preparation metal-doped carbon molecular sieve (CMS) membrane hydrogen separation has been performed. Impregnation Pt(II) acetylacetonate Pd(II) dissolved in supercritical CO2 yielded Pt Pd nanoparticles (diameters 12 5 nm, respectively) that were highly dispersed inside films under optimized conditions. impregnation temperature varieties strongly influenced dispersion metal particles. Pd-doped CMS was...
We describe two recessive alleles of a rice heterochronic gene, plastochron1-1 (pla1-1) and pla1-2, that reduce the length plastochron to approximately half wild type. Because onset reproductive phase in pla1 was not temporally affected, number leaves produced vegetative nearly twice Panicle development severely disturbed mutants. In pla1-1, many primordia primary rachis branches were converted into shoots. These ectopic shoots repeated initiation panicle conversion weak allele however, only...
Whole blood transcriptome analysis is a valuable approachin medical research, primarily due to the ease of sample collection and richness information obtained. Since expression profile individual genes in influenced by traits demographic attributes such as age gender, there has been growing demand for comprehensive database analysis. Here, we performed whole RNA sequencing (RNA-seq) on 576 participants stratified (20-30s 60-70s) gender from cohorts Tohoku Medical Megabank (TMM). A part...
This paper presents a tool to evaluate the latency of Robot Operating System (ROS) 2 applications called Chain-Aware ROS Evaluation Tool (CARET). is designed enhance modularity real-time robotic applications, including self-driving software such as Autoware. To analyze performance CARET supports measurement functionalities for callback latency, node communication time between nodes, and end-to-end latency. calculate each provides tracepoints, an architecture file, information on tracepoint...
Spaceflight-related stresses impact health via various body systems, including the haematopoietic and immune with effects ranging from moderate alterations of homoeostasis to serious illness. Oxidative stress appears be involved in these changes, transcription factor Nrf2, which regulates expression a set cytoprotective antioxidative response genes, has been implicated spaceflight-induced stresses. Here, we show through analyses mice MHU-3 project, Nrf2-knockout travelled space for 31 days,...
A soft optic phonon which is neither Raman nor infrared active has been directly observed for the first time in higher-symmetry phase above ${T}_{a}$ (221.5 K) of hexagonal BaTi${\mathrm{O}}_{3}$ by an experiment hyper-Raman scattering. The underdamped feature soft-phonon mode even close to allows one determine unambiguously both frequency and damping constant as a function temperature. It found that soft-mode obeys Landau-Cochran theory contrast with nonclassical behavior below was...
The aim of this study was to evaluate the effects implemented control measures reduce illness induced by Vibrio parahaemolyticus (V. parahaemolyticus) in horse mackerel (Trachurus japonicus), seafood that is commonly consumed raw Japan. On basis currently available experimental and survey data, we constructed a quantitative risk model V. from harvest consumption. In particular, following factors were evaluated: bacterial growth at all stages, washing fish body storage water, transfer...
Acute kidney injury (AKI) is a leading cause of chronic disease. Proximal tubules are considered to be the primary origin pathogenic inflammatory cytokines in AKI. However, it remains unclear whether other cell types, including collecting duct (CD) cells, participate processes. The transcription factor GATA2 specifically expressed CD cells and maintains their cellular identity. To explore pathophysiological function AKI, we generated renal tubular cell-specific Gata2 deletion (G2CKO) mice...
GATA1 organizes erythroid and megakaryocytic differentiation by orchestrating the expression of multiple genes that show diversified profiles. Here, we demonstrate monovalently binds to a single GATA motif (Single-GATA) while monomeric homodimeric bivalently bind two motifs in palindromic (Pal-GATA) direct-repeat (Tandem-GATA) arrangements, respectively, form higher stoichiometric complexes on respective elements. The amino-terminal zinc (N) finger critically contributes high occupancy...
In positron emission tomography (PET) imaging, image quality correlates with the injected [18F]-fluorodeoxyglucose (FDG) dose and acquisition time. If improves from short-acquisition PET images via super-resolution (SR) deep learning technique, it is possible to reduce FDG dose. Therefore, aim of this study was clarify whether SR technique could improve 50%-acquisition-time level that 100%-acquisition-time image. One-hundred-and-eight adult patients were enrolled in retrospective...
Nuclear DNA content in various parts of Cymbidium plants was measured by flow cytometry. Two types , protocorm-like body (PLB)-propagated epiphytic hybrids and rhizome-propagated terrestrial C. kanran Makino demonstrated polysomaty. Small shoots on PLBs showed two peaks (2C 4C) while four peaks, estimated to be 2C, 4C, 8C, 16C. Roots floral organs excluding ovaries were highly polysomatic as the rhizomes roots . The patterns polysomaty development organ developmental stage specific. Young...
The Ka^^'ma^^'m vortex shedding from a circular cylinder with yaw angle in uniform flow was investigated using wind tunnel. made the irregular and its frequency low. In addition, an intense secondary along generatrix wake just behind induce by yawing. When pair of parallel plates were placed to free order cut off flow, area between became regular returned value for normal one. more when distance smaller, whereas highest attained 1∼1.6 times diameter. It is concluded that depression yawing...
The present studies were carried out in order to establish the method of clonal propagation by leaf tissue culture Phalaenopsis and Vanda.1. Tissues cultured segments dimensions 8-10×8-10mm excised from young seedlings matured plants both orchids, as well tip 5-7mm length infant Vanda whole 8-10mm those Phalaenopsis.The tissues under light on agar media containing various components, subsequent formation protocorm-like bodies (P.L.B.) explants was observed.The first external sign cellular...
In cooperation with the Time and Frequency Group of National Institute Standards Technology, Communications Research Laboratory has developed an optically pumped primary frequency standard (PFS) which is named CRL-O1. The accuracy CRL-O1 been evaluated reports have sent to Bureau International des Poids et Mesures. results evaluations published in Circular T. We estimate biases shifts so-called type A B uncertainties. combination uncertainties about 7 × 10−15. good agreement that other PFSs.