A5101411162- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Vasculitis and related conditions
- Cytokine Signaling Pathways and Interactions
- Heart Rate Variability and Autonomic Control
- Pediatric Pain Management Techniques
- Cardiovascular and Diving-Related Complications
- Inflammatory Myopathies and Dermatomyositis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Viral Infections and Immunology Research
- Shoulder Injury and Treatment
- Congenital Heart Disease Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Spondyloarthritis Studies and Treatments
- Bone health and treatments
- Clinical Nutrition and Gastroenterology
- Sarcoidosis and Beryllium Toxicity Research
- Ocular Diseases and Behçet’s Syndrome
- Rheumatoid Arthritis Research and Therapies
- Orthopaedic implants and arthroplasty
- Monoclonal and Polyclonal Antibodies Research
- Viral Infections and Vectors
Kawasaki Medical School
2024-2025
Seirei Social Welfare Community
2024
Osaka University
2003-2024
Nara Medical University
2022
Aichi Medical University
2007-2021
Saitama Red Cross Hospital
2019
Showa University
2016-2018
Akita University Hospital
2017
Keio University
2016
St. Marianna University School of Medicine
2008-2015
In 1999, the Japan Diabetes Society (JDS) launched previous version of diagnostic criteria diabetes mellitus, in which JDS took initiative adopting glycated hemoglobin (HbA1c) as an adjunct to diagnosis diabetes. contrast, 2009 International Expert Committee composed members American Association (ADA) and European for Study (EASD) manifested recommendation regarding use HbA1c diagnosing mellitus alternative glucose measurements based on updated evidence showing that has several advantages a...
1. On the basis of these findings, we conclude that extermination rats and field mice is a highly important prophylactic measure against Weil's disease. 2. The chemical composition soil water plays animportant part in development Spirochoeta icterohoemorrhagioe, consequently spread disease which it causative agent.
We have already described briefly the portals of entry and excretion pathogenic spirochetes. may mention here that we twice prevented epidemics by disinfection ground removal inundated water in certain places coal mines. In one mine 19 out 50 workmen, another 9 30 workmen came down with Weil's disease about 2 weeks. pointed period during which spirochetes are excreted urine continues, as a rule, for 40 days, must, therefore, apply at least days after first appearance disease. Lately found 21...
A new species of spirochete which we have called Spirochaeta hebdomadis has been described as the specific etiological agent seven day fever, a disease prevailing in autumn Fukuoka and other parts Japan. This is distinguishable from icterohaemorrhagiae to it presents certain similarities. Young guinea pigs are susceptible inoculation with blood patients pure cultures spirochete, those developing infection exhibit definite symptoms suggestive fever man. The serum convalescents contains immune...
High bone turnover elevates the risk of denosumab-induced hypocalcemia in women with postmenopausal osteoporosis Koji Ishikawa,1 Takashi Nagai,1 Keizo Sakamoto,1 Kenji Ohara,2 Takeshi Eguro,1,2 Hiroshi Ito,1 Yoichi Toyoshima,1 Akatsuki Kokaze,3 Tomoaki Toyone,1 Katsunori Inagaki1 1Department Orthopaedic Surgery, Showa University School Medicine, Tokyo, 2Department Yamanashi Red Cross Hospital, Yamanashi, 3Department Public Health, Japan Abstract: Hypocalcemia is most common major adverse...
Summarizing the results that have been cited, we proved blood serum of convalescents from rat-bite fever contains antibodies which are specific against causative agent disease. The was capable destroying spirochetes not only in hanging drop preparations, but also peritoneal cavity guinea pigs. pigs employed for Pfeiffer's test always remained well. In experimentally infected mice receiving intravenously or intraperitoneally equalling quantity amount blood, numbers were greatly decreased they...
Background: Pre‐anesthetic anxiety and emergence agitation are major challenges for anesthesiologists in pediatric anesthesia. Thus, sedative premedication parental presence during induction of anesthesia (PPIA) used to treat pre‐anesthetic children. The aim the present study was test if a combination mother midazolam is effective improving condition children undergoing general Methods: Sixty were allocated one three groups: group (0.5 mg/kg oral midazolam), PPIA or group. When induced with...
To characterize clinical features of polymyositis/dermatomyositis (PM/DM) patients with different anti-aminoacyl transfer RNA synthetase (ARS) antibodies and their association anti-Ro52.Autoantibodies in sera from 97 Japanese (36 PM, 56 DM, 5 clinically amyopathic DM), who satisfied Bohan Peter or modified Sontheimer's criteria, were characterized by immunoprecipitation enzyme-linked immunosorbent assay. Clinical information was medical records. Features associated anti-ARS anti-Ro52...
Horses immunized with cultures of Spirochaeta icterohaemorrhagiae yield an immune serum having therapeutic properties. With rare exceptions the destroys completely spirochetes contained in circulating blood. The development antibodies is promoted by injections. number organs reduced treatment. Secondary manifestations due to are slight and disappear promptly. ultimate effects treatment on symptoms final outcome disease have still be determined.
Abstract Background Edoxaban, a direct oral anticoagulant (DOAC), is first-line treatment for venous thromboembolism (VTE) and the suppression of VTE recurrence. In patients with cancer, however, recurrent after DOAC may be more common than in noncancer patients. To evaluate our hypothesis that anticoagulation effect edoxaban lower cancer Methods This study was prospective, multicenter, observational including treated Japan. The primary outcome difference prothrombin time (PT), activated...
We previously reported high levels of the soluble form IL-6R (sIL-6R) in airways asthmatic subjects. Here, we analyzed effects on Th2 cell survival lung by locally antagonizing sIL-6R-mediated trans-signaling with a designer fusion protein (gp130-Fc) as well signaling an antibody against gp80 unit (αIL-6R) murine model asthma after ovalbumin peptide (OVA) sensitization and challenge. Blockade sIL-6R led to significant decrease inflammatory cells apoptosis-independent mechanism. In contrast,...
In a murine model, interleukin (IL)-17 plays critical role in the pathogenesis of arthritis. There are controversies, however, regarding whether IL-17 is proinflammatory mediator rheumatoid arthritis (RA). We previously established an ex vivo cellular model using synovial tissue (ST)-derived inflammatory cells, which reproduced pannus-like growth and osteoclastic activity vitro. Using this we investigated effects on pannus osteoclastogenesis RA. Inflammatory cells that infiltrated from...
This study investigated the physiologic and sedative parameters associated with a low-dose infusion of dexmedetomidine (Dex). Thirteen healthy volunteers were sedated Dex at loading dose 6 mcg/kg/h for 5 minutes continuous 0.2 25 minutes. The recovery process was observed 60 post infusion. tidal volume decreased significantly despite nonsignificant changes in respiratory rate, minute ventilation, oxygen saturation, end-tidal carbon dioxide. mean arterial pressure heart rate also but within...
Abstract Particles released from orthopedic implants attract immune host defense cells to the bone‐implant interface and contribute development of inflammation. The inflammatory microenvironment supports recruitment differentiation osteoclasts, primary culprit osteolysis. Therefore, understanding complex signals that osteoclastogenesis osteolysis is a sensible approach design strategies inhibit bone loss. signaling cascades coordinate have been widely investigated. These include MAP kinases,...
Abstract Objective We recently developed an ex vivo cellular model of pannus, the aberrant overgrowth human synovial tissue. This study was undertaken to use that investigate role prostaglandin E 2 (PGE ) and its receptor subtypes in development pannus growth osteoclast activity rheumatoid arthritis (RA). Methods Inflammatory cells infiltrated from patients with RA were collected without enzyme digestion designated tissue–derived inflammatory cells. Their single‐cell suspensions cultured...
Aim The present study aimed to determine the real‐world efficacy and safety of non‐structural protein (NS)5A inhibitor elbasvir (EBR) combined with NS3/4A protease grazoprevir (GZR) in patients hepatitis C virus (HCV) genotype 1 (GT1) infection. Methods This retrospectively evaluated rate sustained virologic response at 12 weeks post‐treatment (SVR12) EBR/GZR treatment 159 men 194 women a median age 72 years, it assessed factors associated SVR12 rate. attending physicians were responsible...
Acupressure applied on the Extra 1 acupuncture point results in sedation, thereby reducing bispectral index (BIS) values. Mental status and hypnotic agents influence autonomic nervous system. We hypothesized that acupressure at would induce sedation change sympatho-parasympathetic nerve balance. investigated effect of EEG spectral entropy values heart rate variability (HRV). Forty-eight volunteers (24 males 24 females) were randomly assigned to control or group. The group received a sham...
Maternal distress would correlate with the children's mental status, thereby influencing activity of autonomic nervous system (ANS) children and mothers. We hypothesized that pre-anesthetic maternal ANS activity, when approaching close to their operation time, values heart rate variability (HRV) correlate.We calculated HRVs analyzed relationship between two. A total 24 pairs mother child were analyzed. recorded from night before child's surgery arrival room.The ratios low-frequency...