A5005043146- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Salivary Gland Disorders and Functions
- Nitric Oxide and Endothelin Effects
- Hepatitis B Virus Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Helicobacter pylori-related gastroenterology studies
- Asthma and respiratory diseases
- Head and Neck Cancer Studies
- Cancer survivorship and care
- Pain Mechanisms and Treatments
- Pancreatic and Hepatic Oncology Research
- Neuropeptides and Animal Physiology
- Eicosanoids and Hypertension Pharmacology
- Alcohol Consumption and Health Effects
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Gastrointestinal Tumor Research and Treatment
- Organ Transplantation Techniques and Outcomes
- Psychosomatic Disorders and Their Treatments
- Esophageal and GI Pathology
- Eating Disorders and Behaviors
- Lung Cancer Treatments and Mutations
Nagoya University
2015-2025
Otsuka (Japan)
1992-2024
Hokkaido University
2004-2024
Otsuka Pharmaceutical (Spain)
1992-2024
Aichi Gakuin University
2006-2023
Nanzan University
2023
Tohoku University
2023
Kyoto first Red Cross hospital
2009-2022
Japanese Red Cross Society Kyoto Daini Hospital
2018-2022
University of Miyazaki
2022
Background —Increased production of reactive metabolites oxygen and nitrogen has been implicated in chronic inflammation the gut. The object this study was to examine magnitude location nitric oxide synthase (NOS) activity peroxynitrite formation colonic mucosa patients with ulcerative colitis relation degree inflammation. Subjects —Thirty three active (17 mild or moderate inflammation, 16 severe inflammation). Methods —Inducible NOS determined by measuring conversion l -arginine citrulline...
Gonadal fate in many reptiles, fish, and amphibians is modulated by the temperature experienced during a critical period early life (temperature-dependent sex determination; TSD). Several molecular processes involved TSD have been described but how animals "sense" environmental remains unknown. We examined whether stress-related hormone cortisol mediates between differentiation of pejerrey, gonochoristic teleost fish with marked TSD, possibility that it involves glucocorticoid receptor-...
The pejerrey <i>(Odontesthes bonariensis)</i> is a teleost fish with strong temperature-dependent sex determination (TSD). Several studies have shown that <i>dmrt1</i> and gonadal aromatase <i>(cyp19a1)</i> are implicated in the differentiation process teleosts but little known on expression balance endocrine regulation of these two genes during TSD. This study was designed to clarify patterns both reared at female-, male- mixed-sex-producing temperatures...
Background: Factors associated with response to lenvatinib have not been clarified in patients hepatocellular carcinoma (HCC). Patients and Methods: This study retrospectively analyzed 50 treated as first-line therapy between March 2018 2019. were divided into two groups by the Modified Response Evaluation Criteria Solid Tumours (mRECIST) (responders non-responders, whose best overall responses complete (CR)/partial (PR) stable (SD)/progressive disease (PD), respectively). assessed,...
Abstract Previous reports have shown that during chronic inflammation, the tryptophan (TRP)-kynurenine (KYN) pathway plays a pivotal role in onset of depression. The aim this study was to investigate characteristics serum TRP-KYN metabolite profile high-risk subjects major depressive disorder (HRMDD) defined by depression scores. concentrations metabolites {TRP, KYN, 3-hydroxyanthranilic acid (3HAA), 3-hydroxykynurenine (3HK), kynurenic (KYNA) and anthranilic (AA)} were assessed from HRMDD,...
Background: Lenvatinib (LEN) has been approved for patients with unresectable hepatocellular carcinoma (u-HCC) since March 2018 in Japan. We performed a retrospective nationwide multicenter study to clarify the clinical characteristics of LEN real-world practice. Methods: A total 343 u-HCC who received from May 2020 at 23 sites Japan were registered. Results: During median observation period 10.5 months, 143 died. In Child-Pugh (n = 276) and B 67) patients, overall survival (OS) was 21.0 9.0...
ABSTRACT— To clarify the relationship between angiogenesis and hepatocarcinogenesis on progression of hepatocellular carcinoma (HCC), we quantitatively evaluated by CD34 immunohistochemistry in liver cirrhosis (LC), adenomatous hyperplasia (AH), HCC, proliferative activity estimated Ki‐67 immunohistochemistry. Angiogenesis was using monoclonal antibody HPCA‐2, tumor MIB‐1. We used an image analysis system to assess microvessel density as area percentage endothelial area. generally observed...
Abstract Pejerrey is a teleost fish presenting strong temperature‐dependent sex determination. This study was conducted to clone pejerrey amh cDNA, analyze its expression profile during thermal and endocrine manipulation of gonadal differentiation, compare with that aromatase ( cyp19a1 ). Amh displayed higher at masculinizing than feminizing temperatures the differentiation period. Its an intermediate temperature (females 1:1 males), high in half larvae low other half. Cyp19a1 showed...
Objective We examined the pain-relieving effect of duloxetine on chronic nonorganic orofacial pain (burning mouth syndrome and atypical odontalgia), considering influence baseline depressive symptoms. Methods In this study 12 weeks, was administered in a fixed-flexible dose 20 to 40 mg/d 41 patients with burning and/or odontalgia. Pain evaluated using visual analog scale (VAS) at 2, 4, 6, 8, 10, weeks treatment. Depressive symptoms were assessed Hamilton Depression Rating Scale Results...
Abstract Background/Aims Statins, which are inhibitors of 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase and inhibit endogenous cholesterol synthesis, possess pleiotropic activities, such as anti‐inflammatory, anti‐oxidative antifibrotic effects. Here, we investigated whether statins ameliorate steatohepatitis using a high‐fat high‐cholesterol ( HFHC ) diet‐induced rat model. Methods Eight‐week‐old male Sprague–Dawley rats were fed control chow or diet. Half the diet‐fed orally administered...
Summary Background A predisposition to exacerbations is being recognized as a distinct phenotype with “previous exacerbations” representing the strongest clinical factor associated future exacerbation. Thus, identify additional novel biomarkers asthma exacerbations, “past exacerbation status” must be included confounding factor. Objective This study aimed characterize and biomarker features in severe asthma. Methods We evaluated parameters from 105 asthmatics yearly for 3 years, well their...
Background and aim This study aimed to elucidate whether interferon (IFN)-free direct-acting antiviral (DAA) therapy for hepatitis C after curative treatment of hepatocellular carcinoma (HCC) promotes HCC recurrence in a real-world large-scale cohort. Methods multicenter was conducted by the Japanese Red Cross Hospital Liver Study Group. retrospective analyzed 516 patients who underwent with either IFN (n = 148) or IFN-free DAA 368) treatment; 78 IFN-treated 347 DAA-treated achieved...
This study aims to elucidate the incidence of cancer-related post-traumatic stress (PTS) and fluctuations in anxiety depression levels before one year after laryngectomy. A prospective longitudinal was conducted on 97 consecutive patients scheduled undergo laryngectomy (total or pharyngolaryngectomy) at a single university hospital between 2007 2022. To assess PTS, anxiety, depression, participants completed two brief self-reported questionnaires: Impact Event Scale-Revised (IES-R) Hospital...
Abstract Background Nonalcoholic fatty liver disease is characterized by excessive hepatic fat accumulation. Some individuals frequently present elevated gamma-glutamyl transferase (GGT) levels without ultrasound images and other abnormal enzymes levels. However, whether these are at an risk for developing unclear. We compared change rates factors between with GGT those normal Methods designed a retrospective cohort study on the basis of complete medical checkup records. One group had...
Abstract Background It is unclear whether the fibrosis 4 index (FIB-4), a marker of liver fibrosis, at baseline and change in FIB-4 after sustained virological response (SVR) associated with incident hepatocellular carcinoma (HCC) risk. In this study, we examined association HCC risk high (&gt;3.25) any time point SVR. Methods A total 3823 patients who received direct-acting antiviral treatment achieved SVR were enrolled. The was measured 24 weeks end achievement (SVR24), 1, 2, 3 years...
The risk factors associated with poor prognosis of nonalcoholic fatty liver disease (NAFLD) are not fully understood. Our aim was to assess the role progressive hepatocellular telomere shortening in clinical course NAFLD.We measured average lengths tissue samples from 44 patients NAFLD by quantitative fluorescence situ hybridization using a telomere-specific probe. Patients which telomeres at least 80% age-matched controls were categorized as group A. Those measuring less than control formed...
Abstract Background: In addition to the telomere shortening that occurs with cell division, oxidative stress can damage or shorten telomeres and induce a condition termed premature senescence, possibly before become critically short. We investigated effects of cell‐cycle turnover on cellular senescence in hepatitis C virus (HCV)‐related chronic liver injury. Method: Using quantitative fluorescence situ hybridization, lengths hepatocytes biopsy specimens from HCV‐positive patients were...
Telomere-specific quantitative fluorescent in situ hybridization (Q-FISH) accurately evaluates hepatocellular aging on histological sections, but it requires appropriate tissue processing. To establish a more simple method for the assessment of aging, usefulness nuclear size measurement was clarified using biopsy liver samples from 64 patients with non-alcoholic fatty disease (NAFLD), model oxidative stress-associated and 11 control individuals. Relative telomere intensity (RTI) measured...
The purpose of the present study was to examine extent effects psychopathological symptoms and cognitive function on quality life (QOL) in patients with chronic schizophrenia.Data were obtained using Japanese Schizophrenia Quality Life Scale (JSQLS), Positive Negative Syndrome (PANSS), Wisconsin Card-Sorting Test (WCST) Keio version, Continuous Performance (CPT) for 52 schizophrenia patients.Stepwise regression analysis showed that PANSS depression/anxiety factors predicted JSQLS...
Sorafenib is the standard systemic therapy for patients with advanced hepatocellular carcinoma (HCC). We aimed to assess efficacy and safety of sorafenib in very elderly aged 80 years older HCC.In a retrospective multicenter study Japan, we reviewed 185 (median age, 71 years; 82% male; 95% Child-Pugh class A) HCC who received therapy. Data were compared between 24 (13%) 161 (87%) less than years. used propensity score matching adjust differences two groups.Median overall survival was 10.6...
competitive acid blocker and antibiotics, for Helicobacter pylori (H.pylori ) eradication.
Abstract Objective Comorbid psychiatric disorders negatively affect the survival rate of patients with some physical disorders. In liver transplant recipients, various have been identified as worsening prognosis. However, little is known about how presence any comorbid (overall) recipients. this study, we examined effect overall on in Methods A total 1006 recipients who underwent transplantation between September 1997 and July 2017 across eight facilities a consultation-liaison team were...