A5065534987- Per- and polyfluoroalkyl substances research
- Asthma and respiratory diseases
- Air Quality and Health Impacts
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Birth, Development, and Health
- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Respiratory and Cough-Related Research
- Climate Change and Health Impacts
- Gestational Diabetes Research and Management
- COVID-19 Clinical Research Studies
- Global Health Care Issues
- Chemical Analysis and Environmental Impact
- COVID-19 and healthcare impacts
- Child Nutrition and Water Access
- Carcinogens and Genotoxicity Assessment
- Allergic Rhinitis and Sensitization
- Global Maternal and Child Health
- Global Health and Surgery
- Health disparities and outcomes
- IL-33, ST2, and ILC Pathways
- Pesticide Exposure and Toxicity
- Neonatal Respiratory Health Research
- Global Public Health Policies and Epidemiology
- Pharmacological Receptor Mechanisms and Effects
Hokkaido University
2016-2025
University of Electronic Science and Technology of China
2023
Sapporo University
2015-2022
Institute for Health Metrics and Evaluation
2021-2022
University of Washington
2021-2022
University of California, Davis
2021
Health Sciences University of Hokkaido
2016-2020
Hokkaido University Hospital
2018
<h2>Summary</h2><h3>Background</h3> Previous attempts to characterise the burden of chronic respiratory diseases have focused only on specific disease conditions, such as obstructive pulmonary (COPD) or asthma. In this study, we aimed globally, providing a comprehensive and up-to-date analysis geographical time trends from 1990 2017. <h3>Methods</h3> Using data Global Burden Diseases, Injuries, Risk Factors Study (GBD) 2017, estimated prevalence, morbidity, mortality attributable through an...
Human resources for health (HRH) include a range of occupations that aim to promote or improve human health. The UN Sustainable Development Goals (SDGs) and the WHO Health Workforce 2030 strategy have drawn attention importance HRH achieving policy priorities such as universal coverage (UHC). Although previous research has found substantial global disparities in HRH, absence comparable cross-national estimates existing workforces hindered efforts quantify workforce requirements meet system...
The Hokkaido Study on Environment and Children's Health is an ongoing study consisting of two birth cohorts different population sizes: the Sapporo cohort cohort. Our primary goals are (1) to examine effects low-level environmental chemical exposures outcomes, including defects growth retardation; (2) follow development allergies, infectious diseases, neurobehavioral developmental disorders perform a longitudinal observation child development; (3) identify high-risk groups based genetic...
Fatty acids (FAs) are essential for fetal growth. Exposure to perfluorinated chemicals (PFCs) may disrupt FA homeostasis, but there no epidemiological data regarding associations of PFCs and concentrations.We estimated between perfluorooctane sulfonate (PFOS)/perfluorooctanoate (PFOA) concentrations maternal levels FAs triglyceride (TG) birth size the offspring.We analyzed 306 mother-child pairs in this cohort 2002 2005 Japan. The prenatal PFOS PFOA were measured serum samples by liquid...
Background:Perfluorinated chemicals (PFCs) disrupt cholesterol homeostasis. All steroid hormones are derived from cholesterol, and such as glucocorticoids androgenic mediate several vital physiologic functions. However, the in utero effects of PFCs exposure on homeostasis these not well understood humans.Objectives:We examined relationship between prenatal to perfluorooctane sulfonate (PFOS)/perfluorooctanoate (PFOA) cord blood levels glucocorticoid hormones.Methods:We conducted a...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic that has developed in late 2019 and 2020 is a serious threat to human health. With no vaccines or drugs approved for prevention treatment until now, all efforts at drug design and/or clinical trials of already are worthy creditable. Using structure-based selection identification SARS-CoV-2 protease inhibitors, old such as macrolides (MAC) were predicted be effective COVID-19. Lately, the anti-viral effects have...
Perfluoroalkyl substances (PFAS) are persistent bio-accumulative chemicals that impact the health of pregnant women and their children. PFAS derive from environmental consumer products, which depend on human lifestyle, socioeconomic characteristics, time variation. Here, we aimed to explore temporal trends in characteristics related maternal concentration. Our study is part Hokkaido Study Environment Children’s Health, large-scale cohort recruited between 2003 2011. Blood samples were...
Per- and polyfluoroalkyl substances (PFAS) are widely used bio-accumulative chemicals in many industrial household products. Experimental studies reported that exposure to PFAS results immunotoxicity. We have previously prenatal decreased the risk of allergies, while it increased infectious diseases at ages 2 4 years. However, remains unclear whether adverse effects on allergies continue until a reliable age diagnosing allergies. This study aimed investigating prevalence children up 7, from...
Organophosphate flame retardants (PFRs) are used as additives in plastics and other applications such curtains carpets a replacement for brominated retardants. As such, exposure to PFR mixtures is widespread, with children being more vulnerable than adults associated health risks allergies inflammation. Oxidative stress thought be able modulate the development of childhood airway inflammation atopic dermatitis. To evaluate these associations, present study investigated relationship between...
Prenatal maternal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) has been reportedly associated with decreased birth weight. Although a majority of epidemiological studies concerning perfluoroalkyl substances (PFAS) have focused on PFOS PFOA, PFAS longer carbon chains are scarce. In this study, we investigated whether prenatal 11 PFAS, in particular those chains, is fetal growth. The study included 1985 mother-infant pairs (inclusive preterm post-term...
Abstract Background The Hokkaido Study on Environment and Children’s Health is an ongoing study consisting of two birth cohorts different population sizes: the Sapporo cohort cohort. Our primary objectives are to (1) examine effects that low-level environmental chemical exposures have outcomes, including defects growth retardation; (2) follow development allergies, infectious diseases, neurobehavioral developmental disorders, as well perform a longitudinal observation child development; (3)...
Abstract Background Major disruptions and changes in education have occurred worldwide as a result of the coronavirus disease (COVID-19) pandemic ensuing shift from in-person to online education. However, effect such on medical education, its magnitude, learning domains impacted by rapid not been adequately addressed, particularly with regard objective assessment approaches. Methods Second-year students enrolled our Medical English Course between 2019 2021 were recruited Hokkaido University,...
Summary Background A predisposition to exacerbations is being recognized as a distinct phenotype with “previous exacerbations” representing the strongest clinical factor associated future exacerbation. Thus, identify additional novel biomarkers asthma exacerbations, “past exacerbation status” must be included confounding factor. Objective This study aimed characterize and biomarker features in severe asthma. Methods We evaluated parameters from 105 asthmatics yearly for 3 years, well their...
Phthalate esters and phosphate flame retardants plasticizers (PFRs) are both used as commonly detected in indoor environments. Although phthalates PFRs known to be associated with children's wheeze allergic symptoms, there have been no previous studies examining the effects of mixtures these exposures. To investigate association between exposure phthalate PFRs, symptoms among school-aged children. A total 128 elementary children were enrolled. Metabolites 3 7 measured urine samples....
Thyroid antibodies (TAs) are the most common cause of hypothyroidism during gestation. Although previous studies found that prenatal exposure to perfluoroalkyl substances (PFASs) disrupts thyroid hormones (THs) in humans, their effects on TAs perinatal period have not been investigated.To explore associations between eleven different PFASs from two groups (carboxylates and sulfonates) expression THs maternal cord blood while considering TA status.In a prospective birth cohort (the Hokkaido...