A5032581470- Per- and polyfluoroalkyl substances research
- Air Quality and Health Impacts
- Birth, Development, and Health
- Effects and risks of endocrine disrupting chemicals
- Infant Development and Preterm Care
- Injury Epidemiology and Prevention
- Neonatal and fetal brain pathology
- Health, Environment, Cognitive Aging
- Herpesvirus Infections and Treatments
- Neonatal Respiratory Health Research
- Sleep and Work-Related Fatigue
- Smoking Behavior and Cessation
- Science, Research, and Medicine
- Fatty Acid Research and Health
- Manufacturing Process and Optimization
- Plant Pathogenic Bacteria Studies
- Robotic Mechanisms and Dynamics
- Plant Virus Research Studies
- Toxic Organic Pollutants Impact
- Heavy Metal Exposure and Toxicity
- Anesthesia and Neurotoxicity Research
- Animal testing and alternatives
- Nutrition, Health and Food Behavior
- Heavy metals in environment
- Occupational Health and Performance
National Taiwan University
2016-2025
Taipei Medical University
2022
National Cheng Kung University
1989-2022
Harvard University
2021
Hokkaido University
2018-2020
Sapporo University
2020
Tzu Chi University
2013-2015
The Ohio State University
2005
Breast cancer (BC) is a common in women worldwide; however, the incidence of BC increasing younger women, possibly associated with environment. Perfluoroalkyl substances (PFAS) are one endocrine disruptors that accumulate environment and impact human health. This study aimed to investigate whether PFAS associated. We enrolled 120 BCE patients 119 controls at National Taiwan University Hospital (NTUH) also collected bio-specimen questionnaire from 2013 2015. All subjects' plasma levels were...
Perfluoroalkyl substances (PFAS) are persistent bio-accumulative chemicals that impact the health of pregnant women and their children. PFAS derive from environmental consumer products, which depend on human lifestyle, socioeconomic characteristics, time variation. Here, we aimed to explore temporal trends in characteristics related maternal concentration. Our study is part Hokkaido Study Environment Children’s Health, large-scale cohort recruited between 2003 2011. Blood samples were...
Tackling the spread of COVID-19 remains a crucial part ending pandemic. Its highly contagious nature and constant evolution coupled with relative lack immunity make virus difficult to control. For this, various strategies have been proposed adopted including limiting contact, social isolation, vaccination, contact tracing, etc. However, given heterogeneity in enforcement these fluctuations strictness levels strategies, it becomes challenging assess true impact controlling COVID-19.In present...
Abstract Objectives This study examined whether gestational weight gain (GWG) mediates the relationship between maternal shift work and postpartum retention (PPWR). Methods Mothers with singleton births in Taiwan Birth Cohort Study were assessed for work, GWG, PPWR. Propensity score matching balanced baseline characteristics. We applied multivariable generalized linear regression causal mediation analysis associations, GWG amount excessive as mediators. Results Shift before pregnancy was...
To investigate the plant genes affected by Bamboo mosaic virus (BaMV) infection, we applied a cDNA-amplified fragment length polymorphism technique to screen with differential expression. A serine/threonine kinase-like (NbSTKL) gene of Nicotiana benthamiana is upregulated after BaMV infection. NbSTKL contains homologous domain Ser/Thr kinase. Knocking down expression virus-induced silencing reduced accumulation in inoculated leaves but not protoplasts. The spread GFP-expressing also impeded...
Broadly speaking, the regional structure of a manipulator, which consists inboard three joints and members associated with them, determines workspace shape volume. The orientation structure, which, for six degree freedom furthest outboard members, geometric dexterity or potential manipulator. It is possible, using straightforward arguments, to determine optimal dimensions given total length. By use spherical counterpart Grashof's theorem formulated by Freudenstein, it possible also show that...
The screening of differentially expressed genes in plants after pathogen infection can uncover the potential host factors required for pathogens. In this study, an up-regulated gene was identified and cloned from Nicotiana benthamiana Bamboo mosaic virus (BaMV) inoculation. as a member Rab small guanosine triphosphatase (GTPase) family, designated NbRABG3f according to its silico translated product with high identity that RABG3f tomato. Knocking down expression using virus-induced silencing...
Herpes simplex virus 1 (HSV-1) infects the majority of human population and can induce encephalitis, which is most common cause sporadic, fatal encephalitis. An increase microglia detected in brains encephalitis patients. The issues regarding whether how protect host neurons from HSV-1 infection remain elusive. Using a murine model, we showed that on corneas increased number to outnumber those infiltrating leukocytes (macrophages, neutrophils, T cells) enhanced activation brains. antigens...
Histone modifications control the lytic gene expression of herpes simplex virus 1 (HSV-1). The heterochromatin mark, trimethylation histone H3 on lysine (K) 9 (H3K9me3), is detected HSV-1 genomes at early phases infection to repress viral transcription. However, components and mechanisms involved in process are mostly unknown. Integrin-linked kinase (ILK) activated by PI3K phosphorylate Akt promote several RNA infections. has been shown enhance infection, suggesting a pro-viral role ILK that...
Cesarean section delivery is associated with microbiota disruption and immuno-dysregulation during childhood, but the association Kawasaki disease remains uncertain. We aimed to evaluate between disease.
Abstract Background A high dose of folic acid during pregnancy may increase the risk asthma, wheezing, and respiratory disease in childhood. Folate can modify inflammation immune susceptibility offspring with some epigenetic differentiation, including DNA methylation. This study evaluated associations between maternal folate levels childhood wheezing; furthermore, assessed whether folate‐modified methylation is related to asthma. Methods Participants current were 6651 mother‐child pairs who...
Household incense burning is a common ritual behavior in the Asia-Pacific region but has been associated with inferior developmental outcomes term infants. We aimed to examine these associations among preterm infants.Information from 1190 mother-infant pairs during 6- and 18-month follow-up Taiwan Birth Cohort Study was examined for between household exposure infant neurodevelopmental milestone achievement using multivariable Cox proportional hazard model propensity score weighting, along...
Secondhand smoke exposure during pregnancy has long been associated with adverse health outcomes in children, but only a few studies have examined its effect modifiers. In this study, we applied modification analysis for maternal prepregnancy weight status on detrimental neurodevelopmental of secondhand and infancy nationwide representative population.Term singleton mother-infant pairs nonsmoking mothers were included main (N = 15 987) from the Taiwan Birth Cohort Study (TBCS), further...
Shift work is a prevalent workplace exposure, which increases the possibility of unhealthy behaviours and circadian rhythm disruptions elevates risk metabolic diseases adverse reproductive outcomes. But its potential increasing postpartum weight retention remains uncertain. This study aimed to investigate association between maternal shift prior conception retention, identify modifiable factors during pregnancy for prevention. We analysed data from Taiwan Birth Cohort Study, prospective...
Herpes simplex virus 1 (HSV-1) can induce fatal encephalitis. Cellular factors regulate the host immunity to affect severity of HSV-1 Recent reports focus on significance thrombomodulin (TM), especially domain 1, lectin-like (TM-LeD), which modulates immune responses bacterial infections and toxins various diseases in murine models. Few studies have investigated importance TM-LeD viral infections, are also regulated by immunity.In vivo comparing wild-type knockout mice were performed...