A5044297659- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Immune Response and Inflammation
- Optical Network Technologies
- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Cancer-related Molecular Pathways
- Aortic Disease and Treatment Approaches
- Salivary Gland Disorders and Functions
- Virus-based gene therapy research
- Helicobacter pylori-related gastroenterology studies
- Herpesvirus Infections and Treatments
- Error Correcting Code Techniques
- Immune Cell Function and Interaction
- Peptidase Inhibition and Analysis
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Advanced Wireless Communication Techniques
- Cancer Research and Treatments
Anjo Kosei Hospital
2009-2025
Japanese Red Cross Medical Center
2013-2024
Mitsubishi Electric (Japan)
2002-2024
Chiba University
2013-2023
Eiju General Hospital
2006-2023
Kawasaki Medical School
2004-2020
Hiroshima University
2018
Hiroshima City Asa Citizens Hospital
2016-2017
Matsuyama Shimin Hospital
2016-2017
Brigham and Women's Hospital
2014-2016
Background — The functional changes associated with cellular senescence may be involved in human aging and age-related vascular disorders. We have shown the important role of telomere telomerase cell vitro. Progressive shortening vivo has been observed regions susceptible to atherosclerosis, implying contributions atherogenesis. However, whether senescent cells are present vasculature contribute pathogenesis atherosclerosis remains unclear. Methods Results Senescence-associated...
Abstract Despite the global impact of macrophage activation in vascular disease, underlying mechanisms remain obscure. Here we show, with proteomic analysis cell lines treated either IFNγ or IL-4, that PARP9 and PARP14 regulate activation. In primary macrophages, have opposing roles silencing induces pro-inflammatory genes STAT1 phosphorylation M(IFNγ) cells, whereas it suppresses anti-inflammatory gene expression STAT6 M(IL-4) cells. ADP-ribosylation STAT1, which is suppressed by PARP9....
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide belonging to the vasoactive intestinal polypeptide/glucagon/secretin family. It widely distributed in body, and variety of biological actions have been reported. PACAP exerts its effects by binding specific receptors that are coupled GTP-binding proteins. Recent studies shown there family (PACAPRs), two members this identified. We report here cloning, functional expression, tissue distribution third PACAPR subtype,...
Increased type I interferon (IFN-I) production and IFN-stimulated gene (ISG) expression are linked to the pathogenesis of systemic lupus erythematosus (SLE). Although mechanisms responsible for dysregulated IFN-I in SLE remain unclear, autoantibody-mediated uptake endogenous nucleic acids is thought play a role. 2,6,10,14-tetramethylpentadecane (TMPD; also known as pristane) induces lupus-like disease mice characterized by immune complex nephritis with autoantibodies DNA ribonucleoproteins....
To clarify the effects of hepatitis C virus (HCV) infection on hepatocytes, we analyzed and compared induction intracellular signals by HCV B (HBV) proteins. We examined influence 7 (core, NS2, NS3, NS4A, NS4B, NS5A, NS5B) 4 HBV (precore, core, polymerase, X) proteins 5 well-defined signaling pathways associated with cell proliferation, differentiation, apoptosis use a reporter assay. Viral protein-expression vectors were cotransfected into mammalian cells having luciferase gene driven...
Visceral fat accumulation reportedly increases the risk of hepatocellular carcinoma (HCC) development in patients with chronic liver disease. However, it has not been fully elucidated whether visceral HCC recurrence after curative treatment suspected non-alcoholic steatohepatitis (NASH). Therefore this was investigated current study.62 naive NASH were enrolled. All curatively treated percutaneous radiofrequency ablation between 1999 and 2006. The area (VFA) determined each patient from CT...
We propose a novel SD-FEC employing the concatenation of spatially-coupled type irregular LDPC code with BCH code. Numerical simulations show an NCG 12.0 dB at BER 10−15 25.5% redundancy.
Hepatitis C virus (HCV) infection is a major risk factor for developing hepatocellular carcinoma (HCC), life-threatening sequel. However, the factors that affect disease progression to HCC have not been thoroughly elucidated. Genetic polymorphisms in proinflammatory cytokines, interleukin 1 (IL-1) family (IL-1β and IL-1ra) tumor necrosis factor-α (TNF-α), were studied 274 Japanese patients with chronic HCV 55 healthy individuals using standard polymerase chain reaction-based genotyping...
Hepatitis C virus (HCV) causes a persistent infection, chronic hepatitis, and hepatocellular carcinoma. Since there are several reports indicating that some viruses influence the tumor suppressor p53 function, we determined effects of HCV proteins on function its mechanism by use reporter assay. Among seven investigated (core, NS2, NS3, NS4A, NS4B, NS5A, NS5B), only core protein augmented transcriptional activity increased expression p21(waf1) protein, which is major target p53. Core both...
The mouse (m) DC-SIGN family consists of several homologous type II transmembrane proteins located in close proximity on chromosome 8 and having a single carboxyl terminal carbohydrate recognition domain. We first used transfected non-macrophage cell lines to compare the polysaccharide microbial uptake capacities three these lectins--DC-SIGN, SIGNR1 SIGNR3--to another homologue mLangerin. Each molecule shares potential mannose-recognition EPN-motif its Using an anti-Tag antibody follow...
Three tumor markers for hepatocellular carcinoma (HCC) are available in daily practice Japan: alpha-fetoprotein (AFP), des-gamma-carboxy prothrombin (DCP), and lens culinaris agglutinin-reactive fraction of (AFP-L3). To elucidate the predictability these on HCC recurrence after curative ablation, we enrolled 416 consecutive patients with naïve who had been treated by percutaneous ablation at our department from July 1997 to December 2002. Tumor marker levels were determined immediately...
Extrahepatic metastasis of hepatocellular carcinoma (HCC) is growing importance as the survival patients has been improved owing to advances in treatments intrahepatic lesions.To elucidate incidence and risk factors extrahepatic HCC, we enrolled 1573 (1131 treatment-naïve 442 previously treated on referral) with HCC without tumour spread at authors' department between 1990 2003. Patients received medical treatment including percutaneous ablation transcatheter arterial chemoembolization,...
Epithelial-mesenchymal transition (EMT) refers to critical events occasionally observed during tumor progression, including invasion and metastasis, by which cancer cells acquire a fibroblast-like phenotype. Since the stromal cell-derived factor-1 (SDF-1)/CXCR4 system can facilitate lymph node metastasis in oral squamous cell carcinoma (SCC), we have explored possibility that this might be involved EMT. Oral SCC cells, B88 HNt, functional CXCR4 metastatic potential, were found lose their...
The emergence of resistant hepatitis B virus (HBV), with mutations in the YMDD motif polymerase gene after treatment lamivudine, is becoming an important clinical problem. In this study, susceptibility wild-type and lamivudine-resistant HBV M552I, M552V, L528M/M552V mutants to other reverse transcriptase inhibitors was investigated by transient transfection full-length DNA into human hepatoma cells. replication monitored Southern blot hybridization, which showed presence a single-stranded...
We have established human oral-squamous-cancer cell lines, BHY and HN, derived from non-metastatic cancer metastatic respectively. examined the expression of matrix-degrading enzymes their inhibitors in these lines. Both lines expressed pro-matrix metalloproteinase (MMP)1, proMMP2, proMMP9, membrane-type MMP urokinase-type plasminogen activator. In addition to enzymes, cells secreted proMMP7 procathepsin L, while HN a large amount active MMP2. tissue inhibitor matrix metalloproteinase,...
Forty patients with hepatocellular carcinoma (HCC) (n = 22) or cavernous hemangioma (diameter, 3 cm less) 18) were examined serial magnetic resonance (MR) imaging at 1.5 T the fast low-angle shot (FLASH) technique and an intravenously administered bolus injection of 0.05 mmol/kg Gd-DTPA. Two images per minute obtained for 5 minutes, one thereafter until about 10 minutes. Dynamic MR studies revealed five criteria differentiating these tumors. With HCC there was a hyperintense mass before...
Neoplastic seeding reportedly occurs in up to 12.5% of patients treated with radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC). The aim this study is assess the incidence, risk factors, and prognosis neoplastic after RFA among a large number long-term follow-up.From February 1999 December 2004, 1,031 underwent total 1,845 treatments 3,837 HCC nodules. following variables were assessed elucidate factors seeding: age, sex, positivity viral markers, tumor size, nodules, sessions,...
Background: Lenvatinib (LEN) has been approved for patients with unresectable hepatocellular carcinoma (u-HCC) since March 2018 in Japan. We performed a retrospective nationwide multicenter study to clarify the clinical characteristics of LEN real-world practice. Methods: A total 343 u-HCC who received from May 2020 at 23 sites Japan were registered. Results: During median observation period 10.5 months, 143 died. In Child-Pugh (n = 276) and B 67) patients, overall survival (OS) was 21.0 9.0...
SUMMARY Unlike other agents associated with drug-induced lupus, the isoprenoid alkane pristane induces autoantibodies pathognomonic of including anti-Sm, anti-dsDNA, and anti-ribosomal P in BALB/c SJL/J mice. The susceptibility strains mice to pristane-induced lupus is unknown focus present study. Anti-nRNP/Sm, anti-Su, were produced by most surveyed within several months treatment, although there was marked interstrain variability their frequencies, levels, times onset. In sharp contrast,...
The majority of persons with chronic hepatitis C virus (HCV) infection develop liver fibrosis. Transforming growth factor (TGF)-beta 1 plays a pivotal role in the pathogenesis post-inflammatory scarring. To clarify influence HCV on fibrosis, reporter assay was used to investigate effect viral proteins TGF-beta expression human hepatoma cells. Of all investigated (core, E1/E2/p7, NS2, NS3, NS4A, NS4B, NS5A, and NS5B), only core protein activated promoter upregulated measured by an RNase...