A5017888890- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Diabetes Management and Research
- Diet and metabolism studies
- Nutritional Studies and Diet
- Pancreatic function and diabetes
- Diabetes Management and Education
- Diabetes and associated disorders
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Chronic Disease Management Strategies
- Obesity, Physical Activity, Diet
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Clinical practice guidelines implementation
- Cancer, Lipids, and Metabolism
- Chronic Kidney Disease and Diabetes
- Pharmacology and Obesity Treatment
- Cardiovascular Function and Risk Factors
- Lipoproteins and Cardiovascular Health
- Physical Activity and Health
- Cardiovascular Disease and Adiposity
- Regulation of Appetite and Obesity
Saitama Medical University
2016-2025
International University of Health and Welfare
2019-2025
National Center for Global Health and Medicine
2011-2024
Saitama Medical University Hospital
2020
The University of Tokyo
1997-2017
University of Toyama
2017
Center for Global Health
2010-2016
Diabetes Research Center
2014-2016
Osaka University
2003-2015
Diabetes Australia
2013-2014
In 1999, the Japan Diabetes Society (JDS) launched previous version of diagnostic criteria diabetes mellitus, in which JDS took initiative adopting glycated hemoglobin (HbA1c) as an adjunct to diagnosis diabetes. contrast, 2009 International Expert Committee composed members American Association (ADA) and European for Study (EASD) manifested recommendation regarding use HbA1c diagnosing mellitus alternative glucose measurements based on updated evidence showing that has several advantages a...
Glucokinase (Gck) functions as a glucose sensor for insulin secretion, and in mice fed standard chow, haploinsufficiency of β cell–specific Gck (Gck+/–) causes impaired secretion to glucose, although the animals have normal cell mass. When high-fat (HF) diet, wild-type showed marked hyperplasia, whereas Gck+/– demonstrated decreased replication insufficient hyperplasia despite showing similar degree resistance. DNA chip analysis revealed receptor substrate 2 (Irs2) expression HF diet–fed...
Health insurance claims (ie, receipts) record patient health care treatments and expenses and, although created for the payment system, are potentially useful research. Combining different types of receipts generated same would dramatically increase utility these receipts. However, technical problems, including standardization disease names classifications, anonymous linkage individual receipts, must be addressed.In collaboration with societies, all information from (inpatient, outpatient,...
The current guideline represents the 6th edition of 'Japanese Clinical Practice Guideline for Diabetes' which has been revised every three years since its first appearance in 2004 to promote evidence-based, rational, efficient and consistent clinical practice diabetes. Of note, dramatic progress made recent diabetes research practice, includes approval antidiabetic agents with novel mechanisms action along publication trial results these drugs, diagnostic therapeutic devices, such as...
OBJECTIVE To compare the efficacy of ipragliflozin versus pioglitazone in patients with type 2 diabetes complicated by nonalcoholic fatty liver disease (NAFLD). RESEARCH DESIGN AND METHODS In this open-label, randomized, active-controlled trial, we randomly assigned 66 and NAFLD to receive 50 mg (n = 32) or 15–30 34) orally once daily. The primary outcome was a change from baseline liver-to-spleen attenuation ratio (L/S ratio) on computed tomography at week 24. RESULTS At 24, mean ± SD L/S...
The population of Japan has achieved the longest life expectancy in world. To further improve health, consistent and comparative evidence on mortality attributable to preventable risk factors is necessary for setting priorities health policies programs. Although several past studies have quantified impact individual Japan, our knowledge no study assessed compared effects multiple modifiable non-communicable diseases injuries using a standard framework. We estimated 16 cause-specific deaths...
<b>Objective</b> To examine the association between adherence to Japanese Food Guide Spinning Top and total cause specific mortality. <b>Design</b> Large scale population based prospective cohort study in Japan with follow-up for a median of 15 years. <b>Setting</b> 11 public health centre areas across Japan. <b>Participants</b> 36 624 men 42 970 women aged 45-75 who had no history cancer, stroke, ischaemic heart disease, or chronic liver disease. <b>Main outcome...
Since its inception in 2004, the 'Clinical Practice Guidelines for Treatment of Diabetes' has attempted to promote evidence-based, rational, efficient and standardized clinical practice diabetes Japan undergone revisions every 3 years. Thus, current edition represents fifth revision. Of note, recent years, breakthroughs have been made management complications, which include approval glucose-lowering agents with novel mechanisms action use introduction adoption diagnostic therapeutic...
Mice carrying a null mutation in the glucokinase (GK) gene pancreatic β-cells, but not liver, were generated by disrupting β-cell-specific exon. Heterozygous mutant mice showed early-onset mild diabetes due to impaired insulin-secretory response glucose. Homozygotes severe shortly after birth and died within week. GK-deficient islets isolated from homozygotes defective insulin secretion glucose, while they responded other secretagogues: almost normally arginine some extent sulfonylureas....
The mechanisms underlying the first phase of glucose-stimulated insulin release, deterioration which marks early stages both type 1 and 2 diabetes, are essentially unknown. Among many hypotheses, one holds that is due to a readily releasable pool insulin-containing granules. We used current knowledge exocytosis proteins involved in docking granules at plasma membrane test this hypothesis. A docked was identified by immunoprecipitation protein syntaxin with specific antibody...
We searched for near-infrared extragalactic background light (EBL) in the data from Near-InfraRed Spectrometer (NIRS) on Infrared Telescope Space (IRTS). After subtracting contribution of faint stars and zodiacal component based modeling, a significant isotropic emission is obtained wavelength bands 1.4 micron to 4.0 micron. The in-band flux amounts ~ 35 nW m-2 sr-1 which too bright be explained by integrated galaxies. Significant fluctuations sky brightness were also detected can not due...
The impact of metabolic factors, which are major risk factors for cardiovascular disease, on total cancer has not been clarified. We prospectively examined whether and their aggregates predict the subsequent occurrence sites in Japan Public Health Center-based Prospective Study. A 27 724 participants (9548 men 18 176 women) aged 40–69 years participating a questionnaire health checkup survey 1993–1995 were followed incidence through 2004. Hazard ratios (HR) 95% confidence intervals (CI)...