A5034901951- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Management and Research
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Genetic Associations and Epidemiology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Heart Rate Variability and Autonomic Control
- Diet and metabolism studies
- Receptor Mechanisms and Signaling
- Liver Disease Diagnosis and Treatment
- Lipoproteins and Cardiovascular Health
- Physical Activity and Health
- Phosphodiesterase function and regulation
- Cancer-related gene regulation
- Heart rate and cardiovascular health
- Apelin-related biomedical research
- Non-Invasive Vital Sign Monitoring
- Cancer, Lipids, and Metabolism
- Nutrition and Health in Aging
- Cancer, Hypoxia, and Metabolism
- Blood Pressure and Hypertension Studies
Ehime University
2016-2025
Diabetes Australia
2020
Ehime University Hospital
2009-2015
Ehime Medical Center
2009-2012
Saiseikai Matsuyama Hospital
2009
Ehime Prefectural Central Hospital
2009
Kawamura Hospital
2008
Hiroshima University
2008
Vanderbilt University
1994-2000
Fujita Health University
1995
The current guideline represents the 6th edition of 'Japanese Clinical Practice Guideline for Diabetes' which has been revised every three years since its first appearance in 2004 to promote evidence-based, rational, efficient and consistent clinical practice diabetes. Of note, dramatic progress made recent diabetes research practice, includes approval antidiabetic agents with novel mechanisms action along publication trial results these drugs, diagnostic therapeutic devices, such as...
Abstract We have revised a part of the diagnostic criteria for fulminant type 1 diabetes. The new were set both to express essence this disease rapid increase patients' blood glucose and be highly sensitive reduce misdiagnosis. After analyzing data 382 patients with newly‐diagnosed diabetes, we adopted glycated hemoglobin (HbA 1c ) level 8.7% (National Glycohemoglobin Standardization Program [ NGSP ] value). criterion indicates 100% sensitivity best value by receiver operating characteristic...
The present study was conducted to confirm possible associations between candidate genes from genome-wide association studies and type 2 diabetes in Japanese diabetic patients a community-based general population. A total of 11 previously reported single-nucleotide polymorphisms (SNPs) the TCF7L2, CDKAL1, HHEX, IGF2BP2, CDKN2A/B, SLC30A8, KCNJ11 were analyzed.Candidate SNPs genotyped 506 402 control subjects meta-analyzed with six previous patients. Associations fasting plasma insulin levels...
Hyperglycemia is a risk factor for sarcopenia when comparing individuals with and without diabetes. However, no studies have investigated whether the findings could be extrapolated to patients diabetes relatively higher glycemic levels. Here, we aimed clarify control was associated in type 2 diabetes.Study participants consisted of (n = 746, average age 69.9 years) an older general population 2,067, 68.2 years). Sarcopenia defined as weak grip strength or slow usual gait speed low skeletal...
Abstract Type 1 diabetes is a disease characterized by destruction of pancreatic β‐cells, which leads to absolute deficiency insulin secretion. Depending on the manner onset and progression, it classified as fulminant, acute‐onset or slowly progressive type diabetes. Here, we propose diagnostic criteria for mellitus. Among patients who develop ketosis diabetic ketoacidosis within 3 months after hyperglycemic symptoms require treatment continuously diagnosis diabetes, those with anti‐islet...
ObjectivesType 2 diabetes is a risk factor for sarcopenia. Evidence on the prevention of sarcopenia using blood glucose–lowering therapy limited. We aimed to examine relationship between changes in glycemic control and effect antidiabetic agents against patients with type diabetes.DesignWe conducted an observational longitudinal study.Setting ParticipantsIn total, 588 Japanese ongoing multicenter study completed 1-year follow-up measurements clinical data.MethodsThe data set Multicenter...
The diagnostic criteria for slowly progressive type 1 diabetes (slowly insulin-dependent mellitus; SPIDDM) have been revised by the Committee on Type Diabetes of Japan Society. All following three must be met 'a definitive diagnosis SPIDDM': (1) presence anti-islet autoantibodies at some point in time during disease course; (2) absence ketosis or ketoacidosis with no requirement insulin treatment to correct hyperglycemia immediately after principle; and (3) gradual decrease secretion over...
OBJECTIVE—Resistin, secreted from adipocytes, causes insulin resistance in rodents. We previously reported that the G/G genotype of a resistin gene promoter single nucleotide polymorphism (SNP) at −420 increases type 2 diabetes susceptibility by enhancing activity. report here on relation between plasma and either SNP or factors related to resistance. RESEARCH DESIGN AND METHODS—We cross-sectionally analyzed 2,078 community-dwelling Japanese subjects attending yearly medical checkup. The was...
Aims: This study aims to investigate the association between serum small dense low-density lipoprotein (sdLDL) cholesterol level and development of coronary heart disease (CHD) in a Japanese community.
To characterize the clinical, autoimmune, and genetic features in Japanese adult-onset diabetic patients with GAD autoantibodies.GAD autoantibodies (GADab) were screened 4,980 age of onset >20 years hospital-based Ehime Study, GADab-positive (GADab(+)) then divided into two groups according to their insulin secretion compared nondiabetic subjects. The insulin-deficient state was defined as <0.33 nmol/l serum C-peptide (CPR) at 2 h postprandial or 6 min after a 1-mg glucagon load.GADab...
The hexokinases, by converting glucose to 6-phosphate, help maintain the concentration gradient that results in movement of into cells through facilitative transporters. Hexokinase II (HKII) is major hexokinase isoform skeletal muscle, heart, and adipose tissue. Insulin induces HKII gene transcription L6 myotubes, this, turn, increases mRNA rates protein synthesis phosphorylation these cells. Inhibitors distinct insulin signaling pathways were used dissect molecular mechanism which...
Insulin regulates the activity of key enzymes glucose metabolism in skeletal muscle by altering transcription or translation producing activity-altering modifications preexisting enzyme molecules. Because small size percutaneous biopsies, these phenomena have been difficult to study humans. This was performed determine how physiological hyperinsulinemia activities hexokinase (HK), glycogen synthase (GS), and GLUT-4 human vivo. We determined mRNA abundance, protein content, for proteins...
This study addresses the potential role of skeletal muscle hexokinase (HK) II in regulation glucose uptake and metabolism vivo. Male rats undertook a single bout treadmill exercise were then killed immediately or after predetermined recovery period. Three muscles [soleus (Sol), gastrocnemius/plantaris (Gc), white vastus] excised, HK mRNA, GLUT-4 total (HK I II) heat-stable (predominantly I) activities assessed. hours cessation exhaustive exercise, mRNA was significantly increased all three...
Numerous studies have demonstrated that high blood pressure substantially increases the risk of microvascular and macrovascular complications in patients with type 2 diabetes mellitus (T2DM). Currently, we found serum resistin, an adipocyte- monocyte-derived cytokine, was positively correlated several components metabolic syndrome, including hypertension T2DM. To investigate association resistin etiologic difference among subjects T2DM, without normotensive analyzed 210 subjects, 91 55 64...