A5067387333- Welding Techniques and Residual Stresses
- Advanced Welding Techniques Analysis
- Optical measurement and interference techniques
- Fatigue and fracture mechanics
- Laser and Thermal Forming Techniques
- Engineering Applied Research
- Advanced Measurement and Metrology Techniques
- Non-Destructive Testing Techniques
- Metallurgy and Material Forming
- Connective Tissue Growth Factor Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Metal Forming Simulation Techniques
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Ultrasonics and Acoustic Wave Propagation
- Galectins and Cancer Biology
- Acoustic Wave Resonator Technologies
- Advanced Measurement and Detection Methods
- Numerical methods in engineering
- Industrial Vision Systems and Defect Detection
- Combustion and flame dynamics
- Microfluidic and Bio-sensing Technologies
- dental development and anomalies
- Extracellular vesicles in disease
- Wnt/β-catenin signaling in development and cancer
NGK Spark Plug (Japan)
2023-2025
Osaka University
2007-2023
Brigham and Women's Hospital
2023
Harvard University
2023
Kowa (Japan)
2008-2021
Kumamoto University
2020
Kyushu University
2020
The University of Tokyo
2006-2019
Osaka Prefecture University
2009-2015
Okayama University
2009-2015
Thiazolidinediones have been shown to up-regulate adiponectin expression in white adipose tissue and plasma levels, these up-regulations proposed be a major mechanism of the thiazolidinedione-induced amelioration insulin resistance linked obesity. To test this hypothesis, we generated knock-out (adipo-/-) ob/ob mice with C57B/6 background. After 14 days 10 mg/kg pioglitazone, diabetes were significantly improved association significant up-regulation serum levels. Amelioration was attributed...
Nectins are Ca2+-independent immunoglobulin-like cell-cell adhesion molecules that play roles in organization of a variety junctions cooperation with or independently cadherins. Four nectins have been identified. Five nectin-like molecules, which domain structures similar to those nectins, identified, and we characterized here molecule-2 (Necl-2)/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1. Necl-2 showed homophilic activity. It furthermore heterophilic activity Necl-1/TSLL1/SynCAM3 nectin-3. was widely...
Abstract Aims Calcific aortic valve disease (CAVD) is the most common disease, which consists of a chronic interplay inflammation, fibrosis, and calcification. In this study, sortilin (SORT1) was identified as novel key player in pathophysiology CAVD, its role transformation valvular interstitial cells (VICs) into pathological phenotypes explored. Methods results An (AV) wire injury (AVWI) mouse model with deficiency used to determine effects on AV stenosis, vitro experiments employed human...
Nectins are Ca2+-independent immunoglobulin-like cell-cell adhesion molecules and comprise a family of four members. At the mossy fiber terminals hippocampus, nectin-1 nectin-3 localize at presynaptic postsynaptic sides synaptic junctions, respectively, their trans-interactions play role in formation synapses cooperation with N-cadherin. associated actin cytoskeleton through afadin, nectin- actin-filament-binding protein. Five nectin-like (Necls) which have domain structures similar to those...
Malignant transformation of cells causes disruption cell-cell adhesion, enhancement cell motility, and invasion into surrounding tissues. Nectins have both homophilic heterophilic adhesion activities organize adherens junctions in cooperation with cadherins. We examined here whether Tage4, which was originally identified to be a gene overexpressed colon carcinoma has domain structure similar those nectins, is involved and/or migration. Tage4 heterophilically trans-interacted nectin-3, but...
Abstract Dynamic metabolic changes occur in the liver during transition between fasting and feeding. Here we show that transient ER stress responses following feeding terminated by Sdf2l1 are essential for normal glucose lipid homeostasis. regulates ERAD through interaction with a trafficking protein, TMED10. Suppression of expression results insulin resistance increases triglyceride content sustained stress. In obese diabetic mice, is downregulated due to decreased levels nuclear XBP-1s,...
Abstract This study describes multi-frequency Rayleigh wave excitation below 10 MHz, which is impossible with a conventional piezoelectric-single-crystal surface acoustic (SAW) device. To overcome this limitation, we utilized SAW device an elliptical reflector focusing structure (ELIPS). The prototype ELIPS excited on duralumin at 1.1 3.4 5.6 and 7.9 MHz in the single maximum vibration velocities were 0.38 m s −1 , 0.21 0.070 0.034 respectively, suggests possibility of high-power...
To examine the role of connective tissue growth factor CCN2/CTGF (CCN2) in maintenance articular cartilaginous phenotype, we analyzed knee joints from aging transgenic mice (TG) overexpressing CCN2 driven by Col2a1 promoter. Knee 3-, 14-, 40-, and 60-day-old 5-, 12-, 18-, 21-, 24-month-old littermates were analyzed. Ccn2-LacZ transgene expression cartilage was followed X-gal staining until 5 months age. Overexpression protein confirmed through all ages TG plates. Radiographic analysis showed...
We herein describe a novel procedure for dentin regeneration that mimics the biological processes of tooth development in nature. The canonical Wnt signaling pathway is an important regulator Dentin sialophosphoprotein (Dspp) expression. Our approach underlying nature and focuses on activation to trigger natural process dentinogenesis. coronal portion pulp was removed from first molars. applied lithium chloride (LiCl), activator signaling, amputated surface achieve transdifferentiation...
Adiponectin has been proposed to act as an antidiabetic adipokine, suppressing gluconeogenesis and stimulating fatty acid oxidation in the liver skeletal muscle. Although adiponectin-knockout (adipo(-/-)) mice are known exhibit insulin resistance, degrees of resistance glucose intolerance unexpectedly only moderate. In this study, adipo(-/-) showed hepatic, but not muscle, resistance. insulin-stimulated phosphorylation IRS-1 IRS-2 was impaired, protein level decreased, Akt decreased mice....
Abstract A high-power ultrasonic transducer for minimally invasive treatments is proposed, capable of treating areas inaccessible by high-intensity focused ultrasound treatments. This employs two elliptical reflectors that efficiently focus waves into a thin waveguide utilizing mode conversion. Additionally, slit structure introduced to suppress wave diffraction, further enhancing the focusing capabilities transducer. Finite element analysis demonstrates proposed achieves an impressive...
Previously we showed that CCN family member 2/connective tissue growth factor (CCN2) promotes the proliferation, differentiation, and maturation of cartilage cells in vitro. To elucidate specific role molecular mechanism CCN2 development vivo, present study generated transgenic mice overexpressing analyzed them with respect to bone development. Transgenic were expressing a ccn2/lacZ fusion gene under control 6 kb-Col2a1-enhancer/promoter. Changes histologically immunohistologically also by...
In the analysis of welding mechanics, it is difficult to analyze large-scale structures because welding-specific moving local nonlinearity. this research, authors proposed a new numerical method for mechanics based on Dynamic Explicit FEM. method, temperature step divided into hundreds time steps as implicit FEM and displacements are computed each dynamic explicit until whole system reaches static equilibrium state. And, achieve state faster, modified mass damping matrix introduced. The...
Numerical simulations such as Finite Element Method (FEM) are widely used tool of structural analyses in both design and production. However, the application FEM to welding problems, simulation scale is usually limited joint level. Only a few large-scale performed on existing research because transient problem show strong nonlinearity. In cases, it necessary use static implicit achieve an accurate analysis, but larger analysis requires memory consumption computing time. Thus, we previously...
A new thermal cycle tempering parameter (TCTP) to characterize the effect during multi-pass cycles has been proposed by extending Larson-Miller (LMP) non-isothermal heat treatment. Experimental results revealed that hardness in synthetic HAZ of low-alloy steel subjected a good linear relationship with TCTP. The prediction system was constructed using neural network taking into consideration welding, estimated Based on numerically obtained FEM and experimentally database, distribution welded...
To prevent primary water stress corrosion cracking (PWSCC), jet peening (WJP) has been used on the welds of Ni-based alloys in pressurized reactors (PWRs). Before WJP, are machined and buffed order to conduct a penetrant test (PT) verify weld qualities access, microstructure evolution takes place target area due severe plastic deformation. The compressive residual stresses induced by WJP might be unstable under elevated temperatures because high dislocation density layer. Therefore,...
Abstract Background: Frabin is an actin filament (F‐actin)‐binding protein with GDP/GTP exchange activity specific for Cdc42 small G protein. Expression of frabin forms filopodia‐like microspikes through the direct activation Cdc42, and lamellipodia indirect Rac consists F‐actin‐binding domain (FAB), Dbl homology (DH), first pleckstrin (PH1), FYVE‐finger (FYVE), second PH (PH2) from N‐terminus in this order. Although DH PH1 show activity, FAB, addition to PH1, required formation microspikes,...