A5004829893- Solid State Laser Technologies
- Long-Term Effects of COVID-19
- Laser Design and Applications
- Proteoglycans and glycosaminoglycans research
- Marine Biology and Environmental Chemistry
- Microtubule and mitosis dynamics
- Inflammatory mediators and NSAID effects
- Cell Adhesion Molecules Research
- Photorefractive and Nonlinear Optics
- Bioinformatics and Genomic Networks
- Glycosylation and Glycoproteins Research
- Semiconductor Lasers and Optical Devices
- Heart Rate Variability and Autonomic Control
- Biomedical Text Mining and Ontologies
- Viral-associated cancers and disorders
- Image Enhancement Techniques
- Color Science and Applications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Arsenic contamination and mitigation
- Asthma and respiratory diseases
- Axon Guidance and Neuronal Signaling
- Diatoms and Algae Research
- Environmental Toxicology and Ecotoxicology
- 14-3-3 protein interactions
- Cancer Diagnosis and Treatment
St. Marianna University School of Medicine
2018-2024
Mitsubishi Electric (Japan)
1999-2022
Niigata University
2021
Keihin (Japan)
2019
National Sagamihara Hospital
2018-2019
XData Corporation (United States)
2018
RIKEN Center for Computational Science
2014-2017
Nagoya University
2013-2015
Waseda University
2015
Nara Women's University
1995-2014
Directed differentiation and purification of mesencephalic dopaminergic (mesDA) neurons from stem cells are crucial issues for realizing safe efficient cell transplantation therapies Parkinson's disease. Although recent studies have identified the factors that regulate mesDA neuron development, mechanisms underlying specification not fully understood. Recently, it has been suggested floor plate (FP) acquire neural progenitor characteristics to generate neurons. Here, we directly examined...
Coronavirus disease 2019 (COVID-19) is spreading worldwide; there a need to address its sequelae known as Long COVID. This study evaluated postvaccination changes in symptoms and antibody titers patients with Patients visiting the outpatient department specializing COVID at our hospital were enrolled. Changes before 14-21 days after first vaccination. Antibody measured using ARCHITECT SARS-CoV-2 IgG II Quant same time. included 42 (median age: 45 years; 17 [40.5%] men). Median pre- 456...
Malignant transformation of cells causes disruption cell-cell adhesion, enhancement cell motility, and invasion into surrounding tissues. Nectins have both homophilic heterophilic adhesion activities organize adherens junctions in cooperation with cadherins. We examined here whether Tage4, which was originally identified to be a gene overexpressed colon carcinoma has domain structure similar those nectins, is involved and/or migration. Tage4 heterophilically trans-interacted nectin-3, but...
Rheumatoid arthritis (RA) is an autoimmune disorder involving subsets of activated T cells, in particular helper (Th) 1 and Th17 which infiltrate damage tissues induce inflammation. Prostaglandin E(2) (PGE(2)) enhances the response, exacerbates collagen-induced (CIA) promotes inflammatory pain. The current study investigated whether selective antagonism PGE(2) EP(4) receptor would suppress Th1/Th17 cell development animal models RA.Effects a novel antagonist ER-819762 on Th1 differentiation,...
Abstract EBV-associated gastric carcinoma is a distinct subset of infected with EBV, which shows latency I type expression EBV latent genes (EBNA1, EBER, BARF0, and LMP2A). To clarify the role in this carcinoma, cell biological characteristics (growth, apoptosis, migration) were evaluated lines (MKN-1, TMK1, MKN-74 MKN-7) without infection recombinant harboring neomycin resistance gene. The reiterated infection, only difference observed EBV-infected was to serum deprivation–induced...
Abstract Mutations in the X-linked gene Protocadherin-19 ( Pcdh19 ) cause female-limited epilepsy and mental retardation humans. Although is known to be a homophilic cell-cell adhesion molecule, how its mutations bring about female-specific disorders remains elusive. Here, we report effects of knockout mice on their development behavior. was expressed various brain regions including cerebral cortex hippocampus. Pcdh19-positive cells were evenly distributed layer V wild-type cortices,...
Tight junctions (TJs) consist of transmembrane proteins and many peripheral membrane proteins. To further characterize the molecular organization TJs, we attempted here to screen for novel TJ by fluorescence localization-based expression cloning method. We identified a protein at TJs named it junction-enriched -associated (JEAP). JEAP consists 882 amino acids with calculated weight 98,444. contained polyglutamic acid repeat N-terminal region, coiled-coil domain middle consensus motif binding...
Promoter hypermethylation of various tumor-related genes is extremely frequent in gastric carcinoma (GC) associated with Epstein-Barr virus (EBV). To investigate the significance promoter methylation this type GC, we examined densities regions p14ARF and p16INK4A EBV-associated (n=7) EBV-negative (n=14) GC. Bisulfite sequencing demonstrated a high frequency concurrent EBVaGC. Methylation was observed all 29 CpG sites 16 equally densities. In profiles differed between 2 genes. sporadic...
Obesity-related disorders are closely associated with the development of age-related hearing impairment (ARHI). Adiponectin (APN) exerts protective effects against obesity-related conditions including endothelial dysfunction and atherosclerosis. Here, we investigated impact APN on ARHI. APN-knockout (APN-KO) mice developed exacerbation impairment, particularly in high frequency range, compared wild-type (WT) mice. Supplementation prevented APN-KO At 2 months age, cochlear blood flow...
A high-power diode-pumped Nd:YAG laser oscillating at a wavelength of 1.319 /spl mu/m is reported. 122-W CW beam with an M2 factor 35 has been achieved optical efficiency 19.6%. The lasing characteristics, including thermal lensing, are compared those 1.06 mu/m. Under conditions, the focal length lensing decreases by 25% and increases 15% respect to nonlasing conditions. Based on experimental results, heat dissipation in rod discussed reference nonradiative transitions from upper level.
Drift tube ion mobility spectrometry with a novel atmospheric electron emission (AEE) source was developed for determination of gaseous and blister chemical warfare agents (CWAs) in negative mode. The AEE fabricated from an aluminum substrate electrode covered 1 μm silver nanoparticle-dispersed silicone resin thin gold layer. This structure enabled stable tunneling upon the application more than 11 V potential under pressure. reactant peak (RIP) observed reduced constant ( K0) 2.18 optimized...
The anti-inflammatory effects of etodolac (Eto) were compared with those 6 other drugs : indomethacin (Ind), diclofenac Na (Dic), piroxicam (Pir), naproxen (Nap), ketoprofen (Ket) and aspirin (Asp). Eto inhibited carrageenin-induced edema in rats, adjuvant-induced arthritis acetic acid-induced writhing mice brewer's yeast-induced hyperalgesia fever rats. In the adjuvant test, ED30 value (1.88mg/kg) on day 3 ED50 values (adjuvant-injected paw 1.18mg/kg non-injected 0.96mg/kg) 18 for...
purpose. In this study, biochemistry, molecular biology, immunohistochemistry, and electron microscopy techniques were used to examine whether versican, which is known bind fibrillin-1, interacts with fibrillin-1 in the ciliary body vitreous, versican complex binds hyaluronan. methods. The new polyclonal antibodies against amino carboxyl termini of raised characterized. mRNA expression levels analyzed by RT-PCR real-time PCR, their protein evaluated Western blot analysis...
The centrosomal protein, CDK5RAP2, is a microcephaly protein that regulates maturation by recruitment of γ-tubulin ring complex (γ-TuRC) onto centrosomes. In this report, we identified novel human Cep169, as binding partner member microtubule plus-end-tracking proteins (+TIPs). Cep169 interacts directly with CDK5RAP2 through CM1, an evolutionarily conserved domain, and colocalizes at the pericentriolar matrix (PCM) around centrioles CDK5RAP2. addition, EB1 SxIP-motif responsible for binding,...
Background: Cardiac resynchronization therapy (CRT) has been reported to improve symptoms and cardiac performance in patients with severe heart failure (HF), but CRT recipients advanced HF do not always experience improved mortality rates. Cystatin C recently involved HF, the association of serum cystatin level adverse events long-term prognosis after is unknown. This study investigated whether can predict cardiovascular CRT. Methods Results: A total 117 consecutive receiving a device for...
Cor a 9 and 14 are effective markers for predicting hazelnut allergy. However, there have been no reports on the component-resolved diagnostics (CRD) of allergy using an oral food challenge (OFC) diagnosis in Asia. We hypothesized that CRD would improve accuracy diagnosing allergies Japanese children. recruited 91 subjects (median age: 7.3 years) who were sensitized to hazelnuts had performed OFC at National Hospital Organization Sagamihara between 2006 2017. All classified as allergic or...
Coronavirus disease 2019 (COVID-19) sequelae, also known as long COVID, can present with various symptoms. Among these symptoms, autonomic dysregulation, particularly postural orthostatic tachycardia syndrome (POTS), should be evaluated. However, previous studies on the treatment of POTS complicated by COVID-19 are lacking. Therefore, this study aimed to investigate course COVID POTS.