James Hill
A5065481567- Genetic factors in colorectal cancer
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Treatments and Studies
- Animal Genetics and Reproduction
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Reproductive biology and impacts on aquatic species
- Ion channel regulation and function
- Anorectal Disease Treatments and Outcomes
- Receptor Mechanisms and Signaling
- Cardiac pacing and defibrillation studies
- Muscle Physiology and Disorders
- Marine animal studies overview
- Colorectal and Anal Carcinomas
- Healthcare Systems and Technology
- Heart Failure Treatment and Management
- Cardiac electrophysiology and arrhythmias
- Female Genital Mutilation/Cutting Issues
- Developmental Biology and Gene Regulation
- Identification and Quantification in Food
- Streptococcal Infections and Treatments
- Enhanced Recovery After Surgery
- Bacterial Identification and Susceptibility Testing
- Migration, Health and Trauma
- Molecular Biology Techniques and Applications
Boston Biomedical (United States)
2022
Manchester Royal Infirmary
2017-2022
St. Vincent's University Hospital
2021-2022
Manchester University NHS Foundation Trust
2016-2022
University Hospital of Wales
2022
University of Warwick
2021
New York University Press
2019
University of Manchester
2017
Manchester University
2017
Manchester Academic Health Science Centre
2017
Heritable factors account for approximately 35% of colorectal cancer (CRC) risk, and almost 30% the population in UK have a family history CRC. The quantification an individual's lifetime risk gastrointestinal may incorporate clinical molecular data, depends on accurate phenotypic assessment genetic diagnosis. In turn this facilitate targeted risk-reducing interventions, including endoscopic surveillance, preventative surgery chemoprophylaxis, which provide opportunities prevention. This...
Considerable evidence now suggests that retinoic acid (RA) is an important modulator of patterning events in early neuronal development vertebrates. In this paper, we describe the effects exogenously applied RA on neural zebrafish embryo. Neural anatomy assessed by immunocytochemical and histochemical analysis developing embryo whole mounts at 24 h post-fertilization. was for one hour concentrations ranging from 10(-9) to 10(-6) M embryos 50% epiboly, midgastrula stage, 10(-7) late gastrula...
Abstract Background Pre‐operative weight loss has been consistently associated with increased post‐operative morbidity. The study aims to determine if pre‐operative oral nutritional supplements (ONSs) dietary advice reduce complications. Methods Single‐blinded randomized controlled trial. People colorectal cancer scheduled for surgery >1 kg/3–6 months were by using stratified blocks (1:1 ratio) in six hospitals (1 November 2013–28 February 2015). Intervention group was given 250 mL/day...
Abstract Aim There is a requirement of an expansive and up to date review surgical management inflammatory bowel disease ( IBD ) that can dovetail with the medical guidelines produced by British Society Gastroenterology. Methods Surgeons who are members ACPGBI recognised interest in were invited contribute various sections guidelines. They directed produce procedure based document using literature searches systematic, comprehensible, transparent reproducible. Levels evidence graded. An...
Perianal abscess is common. Traditionally, postoperative perianal cavities are managed with internal wound packing, a practice not supported by evidence. The aim of this randomized clinical trial (RCT) was to assess if non-packing less painful and it associated adverse outcomes.The Postoperative Packing Abscess Cavities (PPAC2) multicentre, RCT (two-group parallel design) adult participants admitted an NHS hospital for incision drainage primary abscess. Participants were 1:1 (via online...
Transgenic coho salmon (Oncorhynchus kisutch) containing a growth hormone gene construct were compared with nontransgenic in terms of gross anatomy, muscle cellularity, enzyme activity, and differential expression. fish found to have significantly higher numbers small-diameter fibres both the dorsal lateral region somitic muscle, suggesting that they grow by greater rates hyperplasia relative slower growing fish. Higher levels activity for phosphofructokinase cytochrome oxidase white...
Studies on the zebrafish model have contributed to our understanding of several important developmental processes, especially those that can be easily studied in embryo. However, knowledge late events such as gonad differentiation is still limited. Here we provide an analysis gene sets expressed adult testis and ovary attempt identify genes with potential role (zebra)fish development function. We produced 10,533 sequence tags (ESTs) from or downloaded additional 23,642 gonad-derived...
Incisional hernias cause morbidity and may require further surgery. HART (Hughes Abdominal Repair Trial) assessed the effect of an alternative suture method on incidence incisional hernia following colorectal cancer
The molecular profile of early-onset colonic cancer is undefined. This study evaluated clinicopathological features and oncological outcomes young patients with according to microsatellite status.
In this study of 400 patients with early-onset rectal cancer, 12.5 per cent demonstrated microsatellite instability (MSI). MSI was associated a reduced likelihood nodal positivity, an increased rate pathological complete response, and improved disease-specific survival.
Three methods used for comparing genomic DNA did not detect a sex‐specific marker in the green spotted pufferfish Tetraodon nigroviridis .
Abstract: Background: Skeletal muscle myopathy is a hallmark of chronic heart failure (HF). Phenotypic changes involve shift in myosin heavy chain (MHC) fiber type from oxidative, MHC I, towards more glycolytic IIx fibers, reductions oxidative enzyme activity, and increase activity. However, it unknown if reversed following transplantation. The purpose this study was to determine the effect transplantation on skeletal metabolic reserve end‐stage HF patients. Methods: Thirteen subjects were...
The development of the Atlantic herring is related to a staging series intended provide standard background for studies embryonic development. based on embryos from Isle Man (Irish Sea) stock reared at 8°C. stages are named rather than numbered in order simplify usage and has been sub‐divided into five periods: zygote cleavage, blastula, gastrula, segmentation, organogenesis.
Abstract A 30‐year‐old woman was referred for follow‐up right‐ and left‐heart catheterization 4 years after cardiac transplantation. She had an implanted epicardial pacemaker bradycardia; this programmed to the DDD mode. At time of her catheterization, as a pigtail catheter pulled back across aortic valve, runs premature ventricular complexes occurred tachycardia with pacing spikes capture initiated at rate 126 beats/min. Adenosine 6 mg given intravenously through femoral venous sheath...