Tamara Glyn
A5069826334- Colorectal Cancer Screening and Detection
- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Diverticular Disease and Complications
- Microscopic Colitis
- Inflammatory Bowel Disease
- Gastric Cancer Management and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Anorectal Disease Treatments and Outcomes
- Appendicitis Diagnosis and Management
- Pelvic and Acetabular Injuries
- Hernia repair and management
- Surgical Simulation and Training
- Cancer Genomics and Diagnostics
- Eosinophilic Esophagitis
- Gastrointestinal Tumor Research and Treatment
- Soft tissue tumor case studies
- Pancreatic and Hepatic Oncology Research
- Tumors and Oncological Cases
- Gastrointestinal disorders and treatments
- Pelvic floor disorders treatments
- Epigenetics and DNA Methylation
- Delphi Technique in Research
Christchurch Hospital
2020-2025
University of Otago
2020-2025
South University
2024
University Hospital Southampton NHS Foundation Trust
2024
Sir Charles Gairdner Hospital
2024
Canterbury District Health Board
2020-2023
Southampton General Hospital
2023
University of Southampton
2023
St. Vincent's University Hospital
2021-2022
St Vincent's Hospital
2018
Abstract Background The incidence of early-onset colorectal cancer (EOCRC), diagnosed before age 50, has been rising in many countries the past few decades. This study aims to evaluate this trend Aotearoa New Zealand and assess its impact on Māori. Methods Crude age-standardized (CRC) was analyzed from all new cases national registry for period 2000–2020. Trends were estimated by sex, ethnicity, group location projections made 2040. Results Between 2000 2020, there a total 56,761 CRC...
Abstract Aim Cryptoglandular anal fistulas carry a substantial burden to quality of life. Surgery is the only effective curative treatment but requires balancing fistula healing against pain, wounds and continence impairment. Sphincter‐preserving procedures do exist demonstrate variable rates success. A lack consistency precision in outcome reporting methodological hinders evidence‐based decision‐making. We aimed establish series minimum standards for interventional studies idiopathic...
Objective Chronic colonic inflammation seen in inflammatory bowel disease (IBD) is a risk factor for colorectal cancer (CRC). Colitis-associated cancers (CAC) are molecularly different from sporadic CRC. This study aimed to evaluate spatially defined molecular changes associated with neoplastic progression identify mechanisms of action and potential biomarkers prognostication. Design IBD patients who had undergone colectomy treatment their or dysplasia were identified an institutional...
Empty pelvis syndrome (EPS) is a significant source of morbidity following pelvic exenteration (PE), but undefined. EPS outcome reporting and descriptors radicality PE are inconsistent; therefore, the best approaches for prevention unknown. To facilitate future research into EPS, aim this study to define measurable core set, descriptor set written definition EPS. Consensus on strategies mitigate was also explored.
Abstract Background Watch and wait (W&W) in complete clinical responders after neoadjuvant chemoradiotherapy has increasingly robust data supporting its oncological safety. Recently, studies have assessed the real‐world costs of this strategy compared to surgical resection. Our aim was compare our safety associated with operative surveillance strategies international literature. Methods Data were retrospectively collected analysed via electronic health records from March 2014 2021...
To establish globally applicable benchmark outcomes for pelvic exenteration (PE) in patients with locally advanced primary (LARC) and recurrent rectal cancer (LRRC), using achieved at highly specialised centres.
The molecular profile of early-onset colonic cancer is undefined. This study evaluated clinicopathological features and oncological outcomes young patients with according to microsatellite status.
The incidence of early-onset colorectal cancer (EOCRC) is increasing. International guidelines state that treatment should not differ from older patients. Several studies have shown patients under 50 years are receiving more aggressive treatment, without any survival benefit. We aim to determine if for stages 2 and 3 EOCRC differs those late-onset (LOCRC)
Risk evaluation of lymph node metastasis for early-stage (T1 and T2) colorectal cancers is critical determining therapeutic strategies. Traditional methods prediction have limited accuracy. This systematic review aimed to the potential artificial intelligence in predicting cancers.
Preoperative exclusive enteral nutrition (EEN) improves nutritional status, reduces intestinal inflammation, and likely surgical outcomes. Crohn’s disease exclusion diet with partial (CDED) also inflammation but its safety preoperatively is unknown. This single-blinded, multicentre, randomised controlled trial of three preoperative therapies aimed to assess the feasibility recruiting retaining patients collecting primary secondary effectiveness Adults undergoing elective surgery a body mass...
Abstract Introduction: Various models have been proposed to effectively provide acute surgical care in Australasia. Recently, General Surgeons Australia (GSA) has published a 12‐point plan with guiding principles on this matter. This study describes model of providing general high‐volume institution, evaluates clinical outcomes and critically appraises the system against GSA plan. Methods: The is qualitatively described quantitative measures workload. laparoscopic cholecystectomy were used...
Background: Restorative proctocolectomy with ileal pouch-anal anastomosis is considered the procedure of choice in patients ulcerative colitis refractory to medical therapy. Subsequent inflammation pouch a common complication and some cases, pouchitis fails respond antibiotics, mainstay treatment. In such corticosteroids, immunomodulatory or biologic treatments are options. However, our understanding efficacy anti-tumour necrosis factor medications both chronic Crohn's-like based on studies...
In this study of 400 patients with early-onset rectal cancer, 12.5 per cent demonstrated microsatellite instability (MSI). MSI was associated a reduced likelihood nodal positivity, an increased rate pathological complete response, and improved disease-specific survival.
The overall incidence of colorectal cancer is decreasing in much the world, yet those under 50 years age increasing (early onset (EOCRC)). reasons for this are unclear. This study was undertaken to describe clinical, pathological and familial characteristics patients with EOCRC their oncological outcomes compare previously published data on late (LOCRC).A retrospective review all diagnosed Canterbury between 2010 2017 conducted. Data collected demographics, family history, treatment,...
Empty pelvis syndrome is a complex challenge resulting from the dead space generated by exenteration.A systematic review of reconstructive techniques to prevent empty cited inconsistent definitions and heterogeneous outcome reporting, was therefore unable make strong conclusions in favour particular strategy 1 .The severity complications escalates with more radical surgery as boundaries are pushed 2,3 guidelines proposed here will establish standardized definitions, outcomes, descriptors,...