A5057548528- Ovarian cancer diagnosis and treatment
- Venous Thromboembolism Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Cancer Cells and Metastasis
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Acute Myocardial Infarction Research
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Cancer Research and Treatments
- Colorectal Cancer Surgical Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Urologic and reproductive health conditions
- Cervical Cancer and HPV Research
- Reconstructive Surgery and Microvascular Techniques
- Genital Health and Disease
- Sarcoma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Case Reports on Hematomas
- Pelvic floor disorders treatments
- Urological Disorders and Treatments
- Surgical Sutures and Adhesives
- Endometriosis Research and Treatment
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
Trinity College Dublin
2013-2024
St. James's Hospital
2014-2024
Molecular Medicine Ireland
2022
Australia New Zealand Gynaecological Oncology Group
2014-2019
University of Cambridge
1999
King's College Hospital
1997
American University of Beirut New York Office
1992
American University of Beirut
1970
Abstract Circulating tumour cells (CTCs) are a critical intermediate step in the process of cancer metastasis. The reliability CTC isolation/purification has limited both potential to report on metastatic progression and development CTCs as targets for therapeutic intervention. Here we new methodology, which optimises culture conditions using primary model system. We exploited known biology that thrive hypoxic conditions, with their survival proliferation being reliant activation...
Empty pelvis syndrome (EPS) is a significant source of morbidity following pelvic exenteration (PE), but undefined. EPS outcome reporting and descriptors radicality PE are inconsistent; therefore, the best approaches for prevention unknown. To facilitate future research into EPS, aim this study to define measurable core set, descriptor set written definition EPS. Consensus on strategies mitigate was also explored.
Platinum resistance is a major cause of treatment failure in ovarian cancer. We previously identified matrix metalloproteinase 9 (MMP-9) as potential therapeutic target chemoresistant disease. A2780cis (cisplatin-resistant) and A2780 (cisplatin-sensitive) carcinoma cell lines were used. The cytotoxic effect MMP-9/MMP-2 inhibitor, (2R)-2-[(4-Biphenylsulfonyl) amino]-3 phenylpropionic acid (C21H19NO4S) alone or combination with cisplatin was determined using high content screening. Protein...
Background Gynecologic cancers are associated with high rates of venous thromboembolism (VTE), which is exacerbated by pelvic surgery and chemotherapy. Objectives The aim this study was to develop validate a risk score for VTE in patients gynecologic cancer test the predictive ability following addition procoagulant biomarker data. Patients methods Clinical laboratory variables were used prediction gynecological (n = 616), validated separate cohort 406). Endogenous thrombin potential D-dimer...
<h3>Objective</h3> Gynaecological cancer patients have a high risk of developing venous thromboembolism (VTE). There is limited information on patient experience and compliance with an extended low molecular weight heparin prophylaxis in this setting. The aim study was to assess compliance, satisfaction the after major surgery for gynaecological cancer. <h3>Methods</h3> This prospective observational conducted large tertiary center between July 2017-March 2018. Consecutive undergoing who...
ObjectivesTo investigate whether HE4 and CA125 could identify endometrioid adenocarcinoma patients who might most benefit from full staging surgery with lymphadenectomy.MethodsSequential a preoperative banked serum histology of endometrium had undergone surgical lymph node dissection over 5-year period between 2011 2016 were included tertiary Gynaecological Cancer Centre, Dublin, Ireland. Preoperative measured using ELISA, the cut-offs 81 pmol/L 35 U/ml. Predictive values estimated AUC,...
Metastatic progression and tumor evolution complicates the clinical management of cancer patients. Circulating cell (CTC) characterization is a growing discipline that aims to elucidate metastasis processes. CTCs offer potential monitor patients for therapy response, disease relapse, screen 'at risk' groups onset malignancy. However, such utility currently limited breast, prostate, colorectal Further understanding basic CTC biology other malignancies required progress them towards utility....
Introduction: High-grade serous ovarian cancer (HGSOC) is the most prevalent and deadliest subtype of epithelial (EOC), killing over 140,000 people annually. Morbidity mortality are compounded by a lack screening methods, recurrence common. Plasminogen-activator-inhibitor 1 (PAI-1, protein product SERPIN E1) involved in hemostasis, extracellular matrix (ECM) remodeling, tumor cell migration invasion. Overexpression associated with poor prognosis EOC. Platelets significantly increase PAI-1...
Ovarian cancer patients are at high risk of thrombosis particularly during chemotherapy treatment however the mechanism is not understood. The aim this study to investigate role activated protein C (aPC) pathway in procoagulant activity observed ovarian undergoing neoadjuvant chemotherapy.Thrombin generation was determined before and after addition thrombomodulin (TM) grade serous (HGSOC) treated with (n = 29) compared HGSOC who were chemo naïve 23) benign tumours 29). Plasma expression...
A 32-year-old patient with primary infertility received in vitro fertilisation (IVF) therapy. Four weeks later she developed intermittent left iliac fossa pain. Transvaginal ultrasound showed an empty uterus and adnexal mass adjacent to the right ovary. Serum β-human chronic gonadotropin was 33 492 IU/L. At laparoscopy a attached ovary, suggestive of ovarian ectopic pregnancy, excised. Histological examination confirmed gestation, but noted enlarged chorionic villi trophoblastic atypia,...