Denis A. Vaughan

ORCID: 0000-0002-7802-0103
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About
Contact & Profiles
Research Areas
  • Assisted Reproductive Technology and Twin Pregnancy
  • Reproductive Biology and Fertility
  • Reproductive Health and Technologies
  • Ovarian function and disorders
  • Prenatal Screening and Diagnostics
  • Sperm and Testicular Function
  • Ectopic Pregnancy Diagnosis and Management
  • Family Dynamics and Relationships
  • Biomedical Ethics and Regulation
  • Reproductive System and Pregnancy
  • CRISPR and Genetic Engineering
  • Gynecological conditions and treatments
  • Ethics and Legal Issues in Pediatric Healthcare
  • Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Sexual Differentiation and Disorders
  • Body Contouring and Surgery
  • Uterine Myomas and Treatments
  • Reproductive Health and Contraception
  • Organ Donation and Transplantation
  • Mobile Health and mHealth Applications
  • COVID-19 Impact on Reproduction
  • Healthcare Policy and Management
  • Endometriosis Research and Treatment
  • Systems Engineering Methodologies and Applications
  • Information Technology Governance and Strategy

Boston IVF
2018-2025

Beth Israel Deaconess Medical Center
2018-2025

Harvard University
2018-2024

Health Alliance International
2024

Hadassah Medical Center
2018-2023

Lemuel Shattuck Hospital
2021-2023

Tufts Medical Center
2013-2023

Southern California Clinical and Translational Science Institute
2023

Hospital Sant Joan de Déu Barcelona
2021

Universitat de Barcelona
2021

Research questionWhat is the psychological impact of COVID-19 pandemic on infertility patients?DesignAn anonymous cross-sectional online survey was sent to patients who attended a large university-affiliated practice in USA between 1 January 2019 and April 2020. At three different time-points respondents were asked note their top stressors, from list 10 commonly reported life stressors.ResultsThe questionnaire 10,481 patients, with 3604 responses (response rate 34%) received. A total 2202...

10.1016/j.rbmo.2020.05.015 article EN other-oa Reproductive BioMedicine Online 2020-06-05

Abstract STUDY QUESTION What is the relationship between sperm DNA fragmentation and oxidative stress (OS) with increasing male age? SUMMARY ANSWER Sperm increases age likely related to both defective spermatogenesis OS levels. WHAT IS KNOWN ALREADY quality declines age. The presence of damage in a high fraction spermatozoa from raw semen sample associated lower fertility natural conception intrauterine insemination. DESIGN, SIZE, DURATION A retrospective cohort study 16 945 samples analysed...

10.1093/humrep/deaa159 article EN Human Reproduction 2020-06-09

What is the treatment path and cumulative live birth (CLB) rate from a single oocyte retrieval of patients who intend to pursue PGT-A at start an IVF cycle compared matched controls?The choice first decreases CLB per for <38 years age, however ≥38 age benefit significantly embryo transfer (ET) when (LB) evaluated.PGT-A has been shown reduce practice transferring multiple embryos confer higher transfer.This retrospective cohort study December 2014 September 2016, involving 600 patients: those...

10.1093/humrep/dey346 article EN Human Reproduction 2018-11-21

(Abstracted from Reprod Biomed Online 2024;49(5):104347) There are many benefits to a frozen embryo transfer (FET) versus fresh in fertility treatments, which can include increased patient autonomy, flexibility, time for genetic testing, improved likelihood of success the transfer, and reduced ovarian hyperstimulation syndrome. Frozen cycles represent large majority transfers United States, research has shown clinical outcomes; data lacking, however, protocols optimal preparation endometrium...

10.1097/ogx.0000000000001393 article EN Obstetrical & Gynecological Survey 2025-04-01

Is there a relationship between endometrial compaction and live birth in euploid frozen embryo transfer (FET) cycles?Live rates (LBRs) were similar both patients that demonstrated or no single FETs.There has been increasing interest the correlation clinical outcomes but conflicting evidence from prior investigations.This was prospective observational study 1 September 2020 to 9 April 2021.This performed at single, academically affiliated fertility center which who had an autologous FET using...

10.1093/humrep/deac060 article EN Human Reproduction 2022-03-24

The objective of our study was to document the efficacy and possible complications in women who were treated for menorrhagia with simultaneous use endometrial ablation levonorgestrel-releasing intrauterine device. Women offered this combined treatment if they complained needed contraception. A structured questionnaire mailed 150 had undergone treatment; 105 (70%) returned a completed questionnaire. mean duration follow-up 25 months (range 6–54 months). Following treatment, 53 (50.5%)...

10.3109/01443615.2012.666581 article EN Journal of Obstetrics and Gynaecology 2012-04-20

What is the impact of day after rescue ICSI (r-ICSI) on success fresh and frozen embryo transfers?The use r-ICSI can virtually allay fears total fertilization failure (TFF) conventional IVF (C-IVF) achieve high live birth rates blastocyst transfer.More infertility clinics have resorted to in place C-IVF treatment owing fear TFF or a low rate. has been attempted either after. Day proved unsuccessful past.A retrospective data analysis was performed 16 608 qualifying cases between April 2010...

10.1093/humrep/dead097 article EN Human Reproduction 2023-05-19

10.1007/s10815-015-0616-x article EN Journal of Assisted Reproduction and Genetics 2015-11-18

Abstract Background With improvements in vitro culture techniques there has been a steady shift practice to transfer embryos at the blastocyst stage (post fertilization day (p.f.d.) 5–7), when reach endometrial cavity during natural conception. For patients with &gt; 5 zygotes on 1 of embryo development, fresh (ET) increases live birth rates compared cleavage (p.f.d. 3) transfer. In poorer prognosis (≤ zygotes) ET is commonly performed reduce risk cycle cancellation if no survives stage....

10.1186/s12978-020-0870-y article EN cc-by Reproductive Health 2020-01-30

Importance Poor ovarian response (POR) to stimulation may impact patients’ desire or need utilize cryopreserved oocytes for family building in the future. These findings, captured by Society Assisted Reproductive Technology (SART) national data, underscore tailored counseling and further research into decision-making processes influencing oocyte utilization. Objective To examine association of number vitrified with likelihood timing patients returning utilization following planned...

10.1001/jamanetworkopen.2023.49722 article EN cc-by-nc-nd JAMA Network Open 2024-01-02
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