A5015358123- Diabetes Management and Research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Childhood Cancer Survivors' Quality of Life
- Celiac Disease Research and Management
- LGBTQ Health, Identity, and Policy
- Digestive system and related health
- Adrenal Hormones and Disorders
- Patient-Provider Communication in Healthcare
- Vitamin D Research Studies
- Ethics and Legal Issues in Pediatric Healthcare
- Diabetes Treatment and Management
- Microbial Metabolites in Food Biotechnology
- Adolescent and Pediatric Healthcare
- Reproductive Health and Technologies
- Hormonal Regulation and Hypertension
- Birth, Development, and Health
- Sexual Differentiation and Disorders
- Eating Disorders and Behaviors
- Sepsis Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Neonatal Respiratory Health Research
- Electrolyte and hormonal disorders
- Breastfeeding Practices and Influences
- Microscopic Colitis
Children's Hospital of Eastern Ontario
2014-2023
University of Ottawa
2013-2023
Royal Manchester Children's Hospital
2023
Queen's University
2023
Ottawa Hospital
2021-2023
Ottawa Hospital Research Institute
2021-2023
Agricultural Research Institute of Ontario
2017-2023
Sandia National Laboratories California
2021
Pediatrics and Genetics
2021
Center for Children
2016
Hypocalcemia and hyperphosphatemia caused by parathyroid hormone (PTH)-resistance are the only discernible abnormalities in pseudohypoparathyroidism type Ib (PHP-Ib). Because mutations PTH/PTH-related peptide receptor, a plausible candidate gene, had been excluded previously, we conducted genome-wide search with four PHP-Ib kindreds established linkage to small telomeric region on chromosome 20q, which contains stimulatory G protein gene. We, furthermore, showed that genetic defect is...
The revised BSPGHAN guidelines for the diagnosis and management of coeliac disease represent an important shift in diagnostic strategy, aimed at simplifying shortening process selected cases. Guidance is given concerning indications testing disease, which still significantly underdiagnosed UK. While screening data suggest a likely incidence 1 100 persons, only 10%-20% this figure currently being diagnosed.The follow new ESPGHAN overall while providing more didactic stratagems, should be...
OBJECTIVE—Two recent genome-wide association (GWA) studies have revealed novel loci for type 1 diabetes, a common multifactorial disease with strong genetic component. To fully utilize the GWA data that we had obtained by genotyping 563 diabetes probands and 1,146 control subjects, as well 483 case subject–parent trios, using Illumina HumanHap550 BeadChip, designed full stage 2 study to capture other possible signals. RESEARCH DESIGN AND METHODS—From our existing datasets, selected 982...
<h3>Importance</h3> The disease process leading to clinical type 1 diabetes often starts during the first years of life. Early exposure complex dietary proteins may increase risk β-cell autoimmunity in children at genetic for diabetes. Extensively hydrolyzed formulas do not contain intact proteins. <h3>Objective</h3> To test hypothesis that weaning an extensively formula decreases cumulative incidence diabetes-associated autoantibodies young children. <h3>Design, Setting, and...
In stage 1 of our genome-wide association (GWA) study for type diabetes, one locus at 16p13 was detected (P = 1.03 x 10(-10)) and confirmed in two additional cohorts. Here we describe the results testing, these cohorts, 23 loci that were next rank statistical significance.Two independent cohorts studied. The Type Diabetes Genetics Consortium replication cohort consisted 549 families with least child diagnosed diabetes (946 total affected) DNA from both parents. Canadian 364 nuclear family...
Early exposure to complex dietary proteins may increase the risk of type 1 diabetes in children with genetic disease susceptibility. There are no intact extensively hydrolyzed formulas.To test hypothesis that weaning an formula decreases cumulative incidence young children.An international double-blind randomized clinical trial 2159 infants human leukocyte antigen-conferred susceptibility and a first-degree relative recruited from May 2002 January 2007 78 study centers 15 countries; 1081...
Over the past 5 years in Canada, clinicians have observed an increasing number of gender-diverse and trans children youth (GDTCY) accessing clinics for gender-affirming care. GDTCY who are able to access care usually accompanied by their families, which provides a unique opportunity integrate them into treatment team. better health social outcomes when strongly supported parents/caregivers. To optimize young people’s well-being, it is essential that we learn more about family experiences...
Background: Canadian specialty clinics offering gender-affirming care to trans and gender diverse children youth have observed a significant increase in referrals recent years, but there is lack of information about the experiences young people receiving care. Furthermore, treatment protocols governing access medical interventions remain topic debate. Aims: This qualitative research aims develop deeper understanding seeking at clinics, including their goals accessing care, feelings they...
Although emergence of gender dysphoria at puberty is long established, a distinct pathway rapid onset was recently hypothesized based on parental data. Using adolescent clinical data, we tested series associations that would be consistent with this pathway, however, our results did not support the hypothesis. Puberty has been understood as one period when often first emerges.1World Professional Association for Transgender HealthStandards care health transsexual, transgender, and...
Rationale: Adrenal insufficiency is a clinical condition associated with fluid- and catecholamine-resistant hypotension.Objectives: The objectives of this study were to determine the prevalence adrenal insufficiency, risk factors potential mechanisms for its development, association clinically important outcomes in critically ill children.Methods: A prospective, cohort was conducted from 2005 2008 seven tertiary-care, pediatric intensive care units Canada on patients up 17 years age existing...
To determine if a structured transition program for young adults with type 1 diabetes improves clinic attendance, glycemic control, diabetes-related distress, quality of life, and satisfaction care.In this multicenter randomized controlled trial, (17-20 years) were randomly assigned to coordinator or standard care. The intervention lasted 18 months (6 in pediatric 12 adult care). primary outcome was the proportion participants who failed attend at least one visit during 12-month follow-up...
Abstract Background Choice of insulin delivery for type 1 diabetes can be difficult many parents and children. We evaluated decision coaching using a patient aid helping youth with decide about method. Methods A pre/post design. Youth parent(s) attending pediatric clinic in tertiary care centre were referred to the intervention by their endocrinologist or physician between September 2013 May 2015. coach guided completing that was pre-populated evidence on options. Primary outcomes parent...
To evaluate safety and effectiveness of MiniMed™ 670G hybrid closed loop (HCL) in comparison with continuous subcutaneous insulin infusion (CSII) therapy for 6 months persons type 1 diabetes (T1D).
Abstract Objective This study aimed to evaluate the effect of a six‐session psychoeducation (PE) program on young women with type 1 diabetes mellitus (DM) and disordered eating attitudes behavior. Method Two hundred twelve attending pediatric clinic were screened for signs disturbance. Of these women, 130 passed screening invited participate in intervention phase study. Eighty‐five subjects randomized PE or treatment‐as‐usual group. Assessments conducted before after treatment at 6‐month...
Epidemiological data implicate puberty as a factor in the initiation of diabetic nephropathy. However, mechanism remains unclear. We hypothesized that would result an increase glomerular hypertrophy and hypertension; these two early concomitant events are seen pivotal to pathophysiology studied effect pubertal duration on three surrogate markers hypertrophy/hypertension: kidney volume (KV), microalbuminuria (MA), Na-Li countertransport (CT). recruited 177 subjects (87 female 90 male; aged...
Abstract Aims To describe the prevalence of impaired glucose tolerance and obesity in offspring mothers whose pregnancies were complicated by gestational diabetes mellitus (GDM) a low‐risk population to investigate effect on these outcomes minimal intervention compared with tight control for management GDM. Methods Eighty‐nine children (mean age 9.1 years, 93% Caucasian) recruited through follow‐up study women previously involved randomized controlled trial (control group) vs. glycaemic...