A5069823843- Radiopharmaceutical Chemistry and Applications
- Prostate Cancer Treatment and Research
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Bone health and osteoporosis research
- Statistical Methods and Inference
- Nutrition and Health in Aging
- Diet and metabolism studies
- Long-Term Effects of COVID-19
- Lymphoma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Nutritional Studies and Diet
- Bone health and treatments
- Renal function and acid-base balance
- Obesity, Physical Activity, Diet
- Health Systems, Economic Evaluations, Quality of Life
- Microscopic Colitis
- Gastrointestinal motility and disorders
- Mathematical Approximation and Integration
- Inflammatory Bowel Disease
- Numerical methods in inverse problems
- Diversity and Career in Medicine
- Cancer Genomics and Diagnostics
- Advanced Mathematical Modeling in Engineering
- Artificial Intelligence in Healthcare and Education
Mayo Clinic
2019-2025
Western Health
2022-2025
University of Edinburgh
2022-2024
Mayo Clinic in Arizona
2020-2024
University of Warwick
2024
WinnMed
2024
Mayo Clinic in Florida
2023
Mayo Clinic Hospital
2023
University of Manchester
2022-2023
Manchester Metropolitan University
2022
One in ten severe acute respiratory syndrome coronavirus 2 infections result prolonged symptoms termed long disease (COVID), yet phenotypes and mechanisms are poorly understood
The field of theranostics is rapidly advancing, driven by the goals enhancing patient care. Recent breakthroughs in artificial intelligence (AI) and its innovative theranostic applications have marked a critical step forward nuclear medicine, leading to significant paradigm shift precision oncology. For instance, AI-assisted tumor characterization, including automated image interpretation, segmentation, feature identification, prediction high-risk lesions, improves diagnostic processes,...
The quality of surgical research, and particularly the reluctance surgeons to perform randomized controlled trials, has been criticized. proportion treatments supported by satisfactory scientific evidence not evaluated previously. A 1-month prospective audit was performed 100 inpatients admitted under two consultants in a general surgical/vascular unit at an urban teaching hospital; main illness interventions were agreed through group discussions each case. literature concerning efficacy...
The revised BSPGHAN guidelines for the diagnosis and management of coeliac disease represent an important shift in diagnostic strategy, aimed at simplifying shortening process selected cases. Guidance is given concerning indications testing disease, which still significantly underdiagnosed UK. While screening data suggest a likely incidence 1 100 persons, only 10%-20% this figure currently being diagnosed.The follow new ESPGHAN overall while providing more didactic stratagems, should be...
Abstract Background Classifying samples in incomplete datasets is a common aim for machine learning practitioners, but non-trivial. Missing data found most real-world and these missing values are typically imputed using established methods, followed by classification of the now complete samples. The focus researcher to optimise classifier’s performance. Methods We utilise three simulated clinical with different feature types missingness patterns. Initially, we evaluate how downstream...
The purpose of this double-blind randomized clinical trial was to compare the relative effectiveness a higher protein and conventional carbohydrate intake during weight loss on body composition physical function in older women.Thirty-one overweight or obese, postmenopausal women (mean ± SD: age 65.2 4.6 years, mass index 33.7 4.9 kg/m(2)) were prescribed reduced calorie diet (1,400 kcal/day; 15%, 65%, 30% energy from protein, carbohydrate, fat, respectively) randomly assigned 2 × 25 g/day...
Purpose To evaluate for appearance-based discrimination in the selection of radiology residents. Method A deception study simulating resident process examined impact attractiveness and obesity on selection. Seventy-four core faculty from 5 academic departments reviewed mock residency applications September October 2017. Each application included demographic information a photograph, representing prespecified distribution facial obesity, combined with randomized supporting variables....
BACKGROUND. COVID-19 vaccination may trigger reactive lymphadenopathy, confounding imaging interpretation. There has been limited systematic analysis of PET findings after vaccination. OBJECTIVE. The purpose this study was to evaluate the frequency and characteristics abnormal FDG 11C-choline uptake on performed METHODS. This retrospective included 67 patients (43 men 24 women; mean [± SD] age, 75.6 ± 9.2 years) who underwent examination between December 14, 2020, March 10, 2021, had...
Background Many patients use artificial intelligence (AI) chatbots as a rapid source of health information. This raises important questions about the reliability and effectiveness AI in delivering accurate understandable Purpose To evaluate compare accuracy, conciseness, readability responses from OpenAI ChatGPT-4 Google Bard to patient inquiries concerning novel 177 Lu-PSMA-617 therapy for prostate cancer. Materials methods Two experts listed 12 most commonly asked by on therapy. These...
Background Patient outcomes and the organisational success of healthcare institutions are largely influenced by wellbeing its staff. Occupational therapy is fastest growing allied health profession in Australia. Current empirical literature, however, has not investigated professional amongst this group. Objective This study explored Victorian bed-based, Grade 2 occupational therapists regarding their identity, job satisfaction, turnover intention, work engagement experiences work-related...
112 Background: We now have more than a decade of experience using Androgen Receptor Pathway Inhibitors (ARPIs) across various disease states prostate cancer, and the safety their combination with Lutetium-177–PSMA-617 has been demonstrated in VISION other large randomized clinical trials. However, real-world data on treatment patterns outcomes involving therapies 177 Lu-PSMA-617 remain limited. Methods: For this analysis, we utilized Mayo Clinic Rochester radiopharmaceutical database,...
114 Background: Oncologists have traditionally relied upon serial assessments of PSA and periodic imaging (i.e., every 2 to 3 cycles) monitor treatment response. Early identification disease progression allows for faster transitions alternative therapies that might be more effective. In this study, we evaluated the utility post-treatment SPECT/CT earlier detection failure in patients receiving Lutetium-177–PSMA-617 (LuPSMA). Methods: We queried an IRB-approved registry including all starting...
Limited data on sex differences in body composition changes response to higher protein diets (PRO) compared carbohydrate (CARB) suggest that a PRO diet helps preserve lean mass (LM) women more so than men.To compare male and female responses weight loss differing macronutrient content.Twelve month randomized clinical trial with 4mo of 8mo maintenance.Overweight (N = 130; 58 (M), 72 (F); BMI 32.5 ± 0.5 kg/m2) middle-aged subjects were energy-restricted (deficit ~500 kcal/d) providing at 1.6...
Abstract Context Prognosis of metastatic pheochromocytoma/paraganglioma following 131-Iodine metaiodobenzylguanidine (MIBG) is incompletely characterized due to small samples and shorter follow-up in these rare, often indolent tumors. Objective To describe long-term survival, frequency, prognostic impact imaging, biochemical, symptomatic response 131-I MIBG. Design Retrospective chart imaging review at a tertiary referral center. Patients Six hundred sixty-eight person-years 125 patients...
Abstract Objectives Implicit bias is common and thought to drive discriminatory behaviour. Having previously demonstrated discrimination against specific applicant demographics by academic radiology departments in a simulated resident selection process, the authors sought better understand relationship between implicit discrimination, as well potential mechanisms for their mitigation. Methods A total of 51 faculty reviewers at three departments, who had participated 2017 audit study which...
175 Background: It is well-known that patients with liver metastases from metastatic castration resistant prostate cancer (mCRPC) have poorer or transient responses to many forms of systemic therapy. Data on outcomes following treatment Lutetium-177–PSMA-617 scarce. The VISION trial reports hazard ratios for overall survival in the subgroup without disclosing absolute duration survival. Using real-world clinical data, we examine this important patients, describing their PSA response rates...
PET/CT is used to evaluate relapsed/refractory non-Hodgkin lymphoma (NHL) prior chimeric antigen receptor T-cell (CAR-T) infusion at two time points: pre-leukapheresis (pre-leuk) and pre-lymphodepletion chemotherapy (pre-LD). We hypothesized that changes in between these points predict outcomes after CAR-T. Metabolic tumor volume (MTV), total lesion glycolysis (TLG), other metrics were calculated from pre-leuk pre-LD scans patients with NHL who received axicabtagene ciloleucel, assessed for...
Abstract Bone metastases occur frequently in common malignancies such as breast and prostate cancer. They are responsible for considerable morbidity skeletal-related events. Fortunately, there now several systemic, focal, targeted therapies that can improve quality length of life, including radionuclide therapies. It is therefore important bone be detected early possible treatment accurately sensitively monitored. Several bone-specific tumor-specific single-photon emission computed...