A5013340888- Diabetes Management and Research
- Diabetes and associated disorders
- Child and Adolescent Health
- Pancreatic function and diabetes
- Childhood Cancer Survivors' Quality of Life
- Obesity, Physical Activity, Diet
- Neonatal Health and Biochemistry
- Neonatal Respiratory Health Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Management and Education
- Global Health Workforce Issues
- COVID-19 Impact on Reproduction
- Growth Hormone and Insulin-like Growth Factors
- Renal Transplantation Outcomes and Treatments
- Thyroid Disorders and Treatments
- Birth, Development, and Health
- Male Breast Health Studies
- Chronic Disease Management Strategies
- Pregnancy and preeclampsia studies
- Eating Disorders and Behaviors
- Coffee research and impacts
- Transplantation: Methods and Outcomes
- COVID-19 and Mental Health
- Innovations in Medical Education
- Metabolism and Genetic Disorders
Children's Hospital of Eastern Ontario
2012-2024
University of Ottawa
2010-2024
Pediatrics and Genetics
2024
Agricultural Research Institute of Ontario
2023
Canadian Paediatric Society
2015-2023
North Manchester General Hospital
2022
Manchester University NHS Foundation Trust
2022
University of Central Florida
2010
University of Maryland Eastern Shore
2009
Endocrinology Research Center
2008
Abstract Background D-bifunctional protein (DBP) deficiency is typically apparent within the first month of life with most infants demonstrating hypotonia, psychomotor delay and seizures. Few children survive beyond two years age. Among patients prolonged survival all demonstrate severe gross motor delay, absent language development, hearing visual impairment. DBP contains three catalytically active domains; an N-terminal dehydrogenase, a central hydratase C-terminal sterol carrier...
The galactopoietic effect of daily injections, for five day periods, growth hormone was examined by measuring milk yield, mammary blood flow and arteriovenous differences glucose amino acids on 12 occasions in four goats.
In thyroid-stimulating-hormone (TSH)-based newborn congenital hypothyroidism (CH) screening programs, the optimal screening-TSH cutoff level is critical to ensuring that true cases of CH are not missed. Screening-TSH results can also be used predict likelihood and guide appropriate clinical management. The purpose this study evaluate predictive value various levels in predicting a diagnosis Ontario Newborn Screening Program (ONSP). initial follow-up data 444,744 full term infants born...
Sports drinks and caffeinated energy (CEDs) are commonly consumed by youth. Both sports CEDs pose potential risks for the health of children adolescents may contribute to obesity. generally unnecessary engaged in routine or play-based physical activity. affect more than adults because they weigh less thus experience greater exposure stimulant ingredients per kilogram body weight. Paediatricians need recognize educate patients families on differences between sport CEDs. Screening consumption...
Diabetes requiring insulin is increasingly common and likely to impact students in most, if not all, schools. its complications have major personal, social economic impact, improved diabetes control reduces the risk of both short- long-term complications. Evidence shows that more intensive management - through frequent blood glucose monitoring, administration with injections and/or pumps, careful attention diet exercise leads better control. Since children spend 30 35 hours per week at...
Pseudohypoparathyroidism (PHP) is a heterogeneous disorder characterized by hypocalcemia and hyperphosphatemia resulting from selective renal resistance to parathyroid hormone (PTH). One autosomal dominant form of PHP type 1b (PHP-Ib) most frequently caused maternally inherited 3-kb deletion within STX16, the gene encoding syntaxin 16. To date, increased bone mineral density (BMD) has been described only in 1a, there lack detailed information on histomorphometry PHP-Ib. The objective this...
Abstract Context The apparent increased incidence of congenital hypothyroidism (CH) is partly due to detection transient disease. Objective This work aims identify predictors CH (T-CH) and establish a predictive tool for its earlier differentiation from permanent (P-CH). Methods A retrospective cohort study was conducted patients diagnosed with 2006 2015 through Newborn Screening Ontario (NSO). Results Of 469 cases, 360 (76.8%) were P-CH vs 109 (23.2%) T-CH. Doses levothyroxine predicting...
Background: Asparaginases are a mainstay treatment for pediatric acute lymphoblastic leukemia (ALL). Recent reports identified hypoglycemia associated with asparaginases. Other describe 6-mercaptopurine (6-MP), another fundamental ALL therapy. Little is known about the risk of therapy, an adverse event that puts children at decreased level consciousness, seizures, and possibly negative neurocognitive sequelae. Methods: We performed retrospective chart review 6 during in our institution from...
To determine lumbar spine and total body bone mineral density (BMD) in pediatric patients who have undergone cranial or craniospinal irradiation for posterior fossa tumors, specifically medulloblastoma ependymoma to analyze the association between degree of osteopenia factors that may affect BMD.Retrospective prospective data collection included medical record review examination, including pubertal, dietary, activity assessment. Lumbar BMD were measured by means dual energy x-ray...
Human recombinant erythropoietin (r-HuEPO) improves quality of life in patients on maintenance haemodialysis, but the haemoglobin (Hb) level necessary to achieve this improvement is unknown. In study, life, functional capacity and symptoms 28 haemodialysis with an initial Hb 67 +/- 2 (mean SEM) g/L were assessed after 0, 6 12 months r-HuEPO, dose which was titrated a stable between 90 100 g/L. At six 97 93 g/L, mean r-HuEPO three six, nine 88 62 9 U/kg/week intravenously respectively. There...
We provide rare in-water evidence of whale sharks feeding on baitballs in the presence other predators. Our observations complexity shark behaviour and a compelling insight into interactions this species with predatory taxa Western Australia.
The childhood and adolescent overweight obesity rates are rising at an alarming rate. Numerous individual, family, community, social factors contribute to in children explored. If left unaddressed, the epidemic of may lead amplified problems for individual children--including acute chronic physical psychological complications--and larger environment. National efforts by researchers a myriad disciplines underway address this issue community levels. These include many steps with which workers...
The Canadian Pediatric Endocrinology Group (CPEG) has produced complementary growth curves based on the 2010 'WHO Growth Charts for Canada'. In response to concerns from CPEG members and general paediatric community regarding presentation of WHO data, were generated, which authors believe will enhance clarity, reduce potential errors in classification enable users better track short-term changes, particularly weight older children. Specifically, these extend weight-for-age beyond 10 years...