A5050357644- Prostate Cancer Treatment and Research
- Sepsis Diagnosis and Treatment
- PARP inhibition in cancer therapy
- BRCA gene mutations in cancer
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- MicroRNA in disease regulation
- DNA Repair Mechanisms
- Respiratory viral infections research
- Statistical Methods in Clinical Trials
- Multiple and Secondary Primary Cancers
- Ethics in Clinical Research
- Non-Invasive Vital Sign Monitoring
- Prostate Cancer Diagnosis and Treatment
- Cardiac tumors and thrombi
- Trauma and Emergency Care Studies
- Clinical Reasoning and Diagnostic Skills
- Cancer, Lipids, and Metabolism
- Ovarian cancer diagnosis and treatment
- AI in cancer detection
- Radiomics and Machine Learning in Medical Imaging
- Healthcare Systems and Public Health
- Artificial Intelligence in Healthcare and Education
- Metastasis and carcinoma case studies
Trinity College Dublin
2021-2025
St. James's Hospital
2020-2024
Tallaght University Hospital
2018-2021
Beaumont Hospital
2017-2018
Royal College of Surgeons in Ireland
2016-2018
Abstract Background: Mismatch repair (MMR) deficiency and microsatellite instability are predictive biomarkers for immunotherapy response. The best approach to identify patients with such tumors is unclear in prostate cancer. Methods: This study included 1,016 men diagnosed primary cancer during prospective follow-up of the Health Professionals Follow-up Study Physicians’ Study. Highest-grade/index lesions from radical prostatectomy (95%) or transurethral resections were mounted on tissue...
Circular RNAs (circRNAs), a recently discovered non-coding RNA, have number of functions including the regulation miRNA expression. They been detected in malignancies prostate cancer (PCa). The differential expression pattern circRNAs associated with PCa and androgen receptor (AR) status was investigated this study. circRNA profiling performed using high throughout microarray assay on panel cell lines, which consisted normal, benign, malignant cells ( n = 9). were more commonly significantly...
Background: Enzalutamide is part of the treatment regimen for metastatic castration-resistant prostate cancer (MCRPC). However, both intrinsic and acquired resistance to drug remain substantial clinical quandaries. circRNAs, a novel type non-coding RNA, have been identified in number cancers including associated with development progression. circRNAs shown great potential as clinically useful blood-based ‘liquid biopsies’ therapeutic targets cancer. The aim this study was examine role...
<h3>Introduction/Background</h3> Metastasis is the primary cause of cancer mortality. The migration tumour cells known as circulating (CTCs) in bloodstream form part 'liquid biopsy'. CTC enumeration serves prognostic marker breast, prostate, and colorectal cancers. However, due to technical challenges, its relevance epithelial ovarian carcinomas (EOC) remains limited. Therefore, we examined CTCs longitudinally serous non-serous EOCs. <h3>Methodology</h3> Peripheral blood samples were...
e13614 Background: Cancer trials in Ireland are conducted both public Health Service Executive (HSE) and private hospitals overseen by Trials (CTI). On the 14 th of May 2021 Irish National HSE was victim a “Conti” ransomware attack. The attack triggered “Critical Incident Process,” shutting down all IT systems at national level. Disruption to patient care across HSE’s 4000 locations, 54 acute hospitals, 70,000 connected devices drastic, immediate without warning. Methods: purpose this study...
5031 Background: Mismatch repair (MMR) deficiency and microsatellite instability (MSI) are predictive biomarkers for immunotherapy response. The best approach to identify patients with such tumors is unclear in prostate cancer. Methods: This study included men diagnosed primary cancer during prospective follow-up of the Health Professionals Follow-up Study (HPFS) Physicians’ (PHS). highest-grade/index lesions tumor tissue from radical prostatectomy (95%) or transurethral resections were...