A5005769424- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Ethics in Clinical Research
- Cancer Immunotherapy and Biomarkers
- Glioma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Breast Cancer Treatment Studies
- Gastric Cancer Management and Outcomes
- Prostate Cancer Treatment and Research
- Ferroptosis and cancer prognosis
- Economic and Financial Impacts of Cancer
- Biomedical Ethics and Regulation
- HER2/EGFR in Cancer Research
- COVID-19 and healthcare impacts
- Cancer Treatment and Pharmacology
- Patient Dignity and Privacy
- Cancer Cells and Metastasis
- Inflammatory Biomarkers in Disease Prognosis
- Global Cancer Incidence and Screening
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer survivorship and care
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Artificial Intelligence in Healthcare and Education
- Radiomics and Machine Learning in Medical Imaging
Cancer Trials Ireland
2012-2024
The University of Texas Health Science Center at Houston
2019
The Netherlands Cancer Institute
2018
University Medical Center Utrecht
2018
Dublin City University
2003-2014
Kent State University
2013
Kent State University at Stark
2010
Increased copy number alterations (CNAs) indicative of chromosomal instability (CIN) have been associated with poor cancer outcome. Here, we study CNAs as potential biomarkers bevacizumab (BVZ) response in metastatic colorectal (mCRC). We cluster 409 mCRCs three subclusters characterized by different degrees CIN. Tumors belonging to intermediate-to-high clusters improved outcome following chemotherapy plus BVZ versus alone. In contrast, low tumors, which amongst others consist POLE-mutated...
Purpose Patients with metastatic colorectal cancer (mCRC) have limited benefit from the addition of bevacizumab to standard chemotherapy. However, a subset probably benefits substantially, highlighting an unmet clinical need for biomarker response bevacizumab. Previously, we demonstrated that losses chromosomes 5q34, 17q12, and 18q11.2-q12.1 had significant correlation progression-free survival (PFS) in patients mCRC treated CAIRO2 trial but not who did receive CAIRO trial. This study was...
Glioblastoma (GBM), being a highly vascularised and locally invasive tumour, is an attractive target for anti-angiogenic anti-invasive therapies. The GBM/endothelial cell response to gossypol/temozolomide (TMZ) treatment was investigated with particular aim assess effects on cancer hallmarks. Cell viability, endothelial tube formation GBM tumour invasion were variously assessed following combined in vitro. U87MG-luc2 subcutaneous xenograft model used investigate therapeutic vivo. Viable...
PURPOSE Cyberattacks are increasing in health care and cause immediate disruption to patient care, have a lasting impact, compromise scientific integrity of affected clinical trials. On the May 14, 2021, Irish service was victim nationwide ransomware attack. Patient disrupted across 4,000 locations, including 18 cancer trials units associated with Cancer Trials Ireland (CTI). This report analyses impact cyberattack on organization proposes steps mitigate future cyberattacks. METHODS A...
The tricyclic antidepressants have previously been shown to exert activity against glioma cells in vitro. Initial studies cell lines suggested that this might extend melanoma cells. We therefore conducted a study primary cultures from metastatic cutaneous deposits using well established ATP-based tumour chemosensitivity assay confirm and these findings. Two eight were exposed three drugs, amitriptyline, nortriptyline clomipramine, at concentrations ranging 200 6.25 µmol/l the assay. All...
Background: Cancer Trials Ireland (CTI) is the national cooperative group in Ireland. The SARS-CoV-2 pandemic led to significant ongoing disruptive change healthcare from March 2020 present day. Its impact and legacy on a clinical trials organisation was assessed. Methods: A review conducted of prospectively acquired communications, team logs time sheets, trial activation, closure accrual, for period 2019 September 2021. An online survey investigators units performed. National Retreat...
Background Circulating tumour cells (CTCs) represent a morphologically distinct subset of cancer cells, which aid the metastatic spread. The ExPeCT trial aimed to examine effectiveness structured exercise programme in modulating levels CTCs and platelet cloaking patients with prostate cancer. Methods Participants (n = 61) were randomised into either standard care (control) or arms. Whole blood was collected for all participants at baseline (T0), three months (T3) six (T6), analysed presence...
Interactions between circulating tumour cells (CTCs) and platelets are thought to inhibit natural killer(NK)-cell-induced lysis. We attempted correlate CTC numbers in men with advanced prostate cancer platelet counts lymphocyte numbers. Sixty-one ExPeCT trial participants, divided into overweight/obese normal weight groups on the basis of a BMI ≥ 25 or <25, were randomized participate not six-month exercise programme. Blood samples at randomization, three six months, subjected ScreenCell...
DNA methylation is altered in many types of disease, including metastatic colorectal cancer. However, the methylome has not yet been fully described archival formalin-fixed paraffin embedded (FFPE) samples context matched fresh-frozen (FF) tumor material at base-pair resolution using a targeted approach. Using next-generation sequencing, we investigated three pairs FFPE and FF to determine extent their similarity. We identified 'bowing' pattern specific categorized by lower CG proportion...
<b><i>Background/Aims:</i></b> This study is aimed at analyzing the survival rates and prognostic factors of stage IV colorectal cancer patients from 3 European cohorts undergoing combination chemotherapy with bevacizumab. <b><i>Methods:</i></b> Progression free-survival (PFS) overall (OS) were analyzed in 172 using Kaplan-Meier method uni- multivariable Cox proportional hazards regression models. <b><i>Results:</i></b>...
In this article, the authors describe a classroom incident and their subsequent learnings about effectively managing issues of gender diversity in an MBA course titled “Women Organizations.” The employ Kolb’s learning cycle as framework for describing ( concrete experience), reflecting on discussing what occurred reflective observation), examining pertinent literature possible explanations abstract conceptualization ), devising practical strategies to mitigate such incidents future active...
Combining bevacizumab and chemotherapy produced superior response rates compared with alone in metastatic breast cancer. As may cause hypertension (HTN) increase the risk of cardiac failure, we performed a pilot study to evaluate feasibility toxicity non-anthracycline-containing combination docetaxel cyclophosphamide early stage cancer patients.Treatment consisted four 3-weekly cycles (75/600 mg/m2). Bevacizumab was administered 15 mg/kg intravenously on day 1, then every 3 weeks total 18...
Abstract Purpose All patients living with cancer, including those metastatic are encouraged to be physically active. This paper examines the secondary endpoints of an aerobic exercise intervention for men prostate cancer. Methods ExPeCT (Exercise, Prostate Cancer and Circulating Tumour Cells), was a multi-centre randomised control trial 6-month arm or standard care arm. Exercise adherence data collected via heart rate monitors. Quality life (FACT-P) physical activity (self-administered...
Purpose Research from numerous theories shows teams' information sharing and discussion enhances effectiveness. Likewise, team communication structure can increase sharing, manage conflict productively foster creativity. However, the lack of unifying theory hinders understanding disparate research findings. Agazarian aims to unify field with her meta‐theoretical, multi‐level Theory Living Human Systems (TLHS). Furthermore, TLHS‐derived Systems‐Centered Training (SCT) presents an innovative...
Abstract Chemotherapy combined with the angiogenesis inhibitor bevacizumab (BVZ) is approved as a first-line treatment in metastatic colorectal cancer (mCRC). Limited clinical benefit underpins need for improved understanding of resistance mechanisms and elucidation novel predictive biomarkers. We assessed germline single-nucleotide polymorphisms (SNPs) 180 mCRC patients (Angiopredict [APD] cohort) treated BVZ + chemotherapy investigated previously reported SNPs. further employed machine...
Cancer clinical trials (CCTs) are critical to translation and development of better therapies improve outcomes. CCTs require adequate patient involvement but accrual rates low globally. Several known barriers impede participation knowing how subpopulations differ in understanding can foster targeted approaches aid advance cancer treatments. We conducted the first nationwide survey 1089 patients attending 14 Irish centres, assessing fundamental concepts CCT methodology factors that influence...
Abstract Lymphocytic infiltrate is a known prognostic biomarker in estrogen receptor(ER)-negative breast cancers (BCs). Comparatively ER+ disease putatively cold, however, there exists an infiltrate-rich subset of tumours with significant spatial heterogeneity and unknown clinical impact. Using serial sections taken from early-stage, ER+/HER2- Irish patients enrolled the TAILORx trial (n=450), we aimed to investigate potential markers encompassing tumour architecture. Immunohistochemistry...