A5034815587- Cancer survivorship and care
- Colorectal Cancer Screening and Detection
- Breast Lesions and Carcinomas
- Spinal Cord Injury Research
- Breast Cancer Treatment Studies
- Gut microbiota and health
- Inflammatory Biomarkers in Disease Prognosis
- Cardiovascular Function and Risk Factors
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Cancer and Skin Lesions
- Barrier Structure and Function Studies
- Lung Cancer Treatments and Mutations
- Cardiovascular Syncope and Autonomic Disorders
- Inflammatory Bowel Disease
- Prostate Cancer Treatment and Research
- Heart Rate Variability and Autonomic Control
- Diverticular Disease and Complications
- Lung Cancer Research Studies
- Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Renal cell carcinoma treatment
- Mycobacterium research and diagnosis
University of British Columbia
2017-2025
Cork University Hospital
2016-2025
University College Cork
2020-2024
International Collaboration On Repair Discoveries
2017-2022
Trinity College Dublin
2004-2019
King's College Hospital
2019
St. James's Hospital
2011-2017
St. Vincent's University Hospital
2008-2013
Cystic Fibrosis Canada
2013
East Carolina University
2012
Abstract Background Histologic remission (HR) is a critical treatment target in Ulcerative Colitis (UC). Among several scoring systems, the PICaSSO Remission Index (PHRI) simplifies HR assessment by evaluating presence of neutrophils bowel tissue. Our artificial intelligence (AI) system built upon PHRI showed remarkable accuracy assessment. assess four different regions interest, so segmentation these compartments crucial to predict automatically. However, creating labelled histopathological...
Research into the pathogenesis underlying development of idiopathic pulmonary fibrosis is hampered by a repertoire animal models that fail to recapitulate all features human disease. Better use and understanding what represent may improve clinical predictability. We interrogated ex vivo micro-computed tomography (CT) as novel end-point measure in mouse model bleomycin-induced lung (BILF), evaluate therapeutic dosing regimen for preclinical drug evaluation. A detailed characterisation BILF...
Abstract Spinal cord injury chronically alters cardiac structure and function is associated with increased odds for cardiovascular disease. Here, we investigate the consequences of spinal on acute-to-chronic continuum, contribution altered bulbospinal sympathetic control to decline in following injury. By combining experimental rat models prospective clinical studies, demonstrate that causes a rapid sustained reduction left ventricular contractile precedes structural changes. In rodents,...
Patients with inflammatory bowel disease (IBD) in clinical and endoscopic remission may still experience relapse. Therefore, there is a need to identify outcome predictors. Recently, the role of neutrophils predicting outcomes ulcerative colitis (UC) has been highlighted. Furthermore, impairment intestinal barrier plays key forecasting IBD.
Abstract Background Artificial Intelligence (AI)- enabled endoscopy and histology offer accurate, objective, rapid assessment of disease activity in Ulcerative Colitis (UC). Emerging multi-source AI models integrating diverse datasets may enhance standardised evaluation outcome prediction. This study aimed to develop a novel model fusing endoscopic histological findings improve the remission predict early response therapy UC clinical trials. Methods A multimodal fusion algorithm was...
Abstract Background Virtual Chromoendoscopy (VCE) is pivotal for assessing activity and predicting outcomes in Ulcerative Colitis (UC), though inter- intra-observer variability the need expertise persist. Artificial intelligence (AI) has potential to offer standardised VCE-based assessment. This study introduces a novel AI model detect, generate transition between various endoscopic modalities, enhancing AI-driven inflammation assessment outcome prediction UC. Methods Endoscopic videos...
Abstract Background The intestinal barrier is gaining recognition as a key indicator of mucosal healing in IBD. Nonetheless, its assessment remains challenging. This study evaluates advanced endoscopic tools for real-time gut assessment, examining their correlation with automated epithelial and vascular markers exploring potential to elucidate the gut-brain axis. Methods IBD patients undergoing or surveillance healthy controls were included. mucosa was assessed imaging, i.e. ultra-high...
Abstract Background Achieving histological remission is a key treatment goal in Ulcerative Colitis (UC) as it associated with better disease management and predicts response to therapy. Neutrophils are the drivers of activity UC are, therefore, integral many scoring systems. However, current methods remain complex subject inter-rater variability. Thus, our study aimed develop novel AI-driven model standardise detection, localisation, quantification neutrophils, supporting evaluation enabling...
Needle core biopsy (NCB) is a widely-used technique for non-operative evaluation of screen-detected breast lesions. Although most NCBs are B2 (benign) or B5 (malignant), some fall into the B3 category "uncertain malignant potential". This study aims to categorise lesions prompting NCB in Merrion Breast Screening Unit, and establish incidence malignancy on subsequent excision biopsy.Patients attending Unit Dublin between 2000 2008 who had were identified. The pathology reports reviewed...
Individuals with spinal cord injury (SCI) have been shown to exhibit systolic, and a lesser extent, diastolic cardiac dysfunction. However, previous reports of dysfunction in this population are confounded by the changing loading conditions after SCI as such, whether per se is present still unknown. Therefore, our aim was establish if load-independent SCI, understand functional response explore changes within cellular milieu myocardium. Here, we applied vivo echocardiography left-ventricular...
The Saint James's Hospital Biobank was established in 2008, to develop a high-quality breast tissue BioResource, as part of the cancer clinical care pathway. aims this work were: (1) ascertain quality RNA, DNA, and protein biobanked carcinomas normal tissues, (2) assess efficacy AllPrep(®) (Qiagen) isolating simultaneously, (3) compare AllPrep with RNEasy(®) QIAamp(®) (both Qiagen), (4) examine effectiveness Allprotect(®) (Qiagen), new stabilization medium preserving proteins. One hundred...
Abstract Background PSC colitis is associated with an increased risk of colorectal carcinoma. Endoscopic monitoring crucial since endoscopic and histological activity can persist in even during clinical remission. Recent evidence suggests that the presence barrier dysfunction may predict relapse quiescent patients. This study aims to assess mucosal healing evaluate potential outcomes by combining ultra-high magnification endocytoscope (ECS) intestinal protein markers. Methods 23 PSC-colitis...
Cancer patient outcomes and selection for novel therapies are heavily influenced by the immune contexture of tumor microenvironment. Esophageal cancer is associated with poor outcomes. In contrast to colorectal cancer, where immunoscore increasingly used in prognostic staging, little known about cell populations esophageal adenocarcinoma (EAC) squamous carcinoma (SCC), their clinical significance.Tissue microarrays were constructed from resected tissue 72 EAC patients 23 SCC patients....
Background Circulating tumour cells (CTCs) represent a morphologically distinct subset of cancer cells, which aid the metastatic spread. The ExPeCT trial aimed to examine effectiveness structured exercise programme in modulating levels CTCs and platelet cloaking patients with prostate cancer. Methods Participants (n = 61) were randomised into either standard care (control) or arms. Whole blood was collected for all participants at baseline (T0), three months (T3) six (T6), analysed presence...