A5065024263- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Respiratory Health Research
- Child Abuse and Trauma
- Immunotherapy and Immune Responses
- Structural Engineering and Vibration Analysis
- Structural Analysis of Composite Materials
- Child Abuse and Related Trauma
- Inhalation and Respiratory Drug Delivery
- Homicide, Infanticide, and Child Abuse
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Injury Epidemiology and Prevention
- Pneumonia and Respiratory Infections
- Radiation Dose and Imaging
- Multiple Myeloma Research and Treatments
- Retinal Diseases and Treatments
- Mesenchymal stem cell research
- Atherosclerosis and Cardiovascular Diseases
- Child and Adolescent Health
- Body Contouring and Surgery
- Asthma and respiratory diseases
- Protein Degradation and Inhibitors
- Eosinophilic Disorders and Syndromes
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
Michigan State University
2018
University College London
2007-2016
Centre for Inflammation Research
2012-2015
University of Washington
2013
Progenitor Cell Therapy (United States)
1997
University of Iowa Hospitals and Clinics
1990-1997
University of North Carolina at Chapel Hill
1997
Ly-6A is a murine antigen which implicated in lymphocyte activation and may be involved of hematopoietic stem cells. Antibody cross-linking studies antisense experiments have suggested that coactivation molecule. To better understand the function Ly-6A, we used gene targeting to produce null mice are healthy normal numbers percentages lineages. However, T lymphocytes from Ly-6A–deficient animals proliferate at significantly higher rate response antigens mitogens than wild-type littermates....
Research into the pathogenesis underlying development of idiopathic pulmonary fibrosis is hampered by a repertoire animal models that fail to recapitulate all features human disease. Better use and understanding what represent may improve clinical predictability. We interrogated ex vivo micro-computed tomography (CT) as novel end-point measure in mouse model bleomycin-induced lung (BILF), evaluate therapeutic dosing regimen for preclinical drug evaluation. A detailed characterisation BILF...
Abstract Thymic stromal lymphopoietin (TSLP) recently has emerged as a key cytokine in the development of type 2 immune responses. Although traditionally associated with allergic inflammation, responses are also recognized to contribute pathogenesis tissue fibrosis. However, role TSLP non–allergen-driven diseases, characterized by profibrotic phenotypes and excessive fibroblast activation, remains underexplored. Fibroblasts represent effector cells responsible for extracellular matrix...
Objectives: Provide background for use of acquiring autologous adipose tissue as a graft and source adult progenitor cells in cosmetic plastic surgery. Discuss the mechanisms action closed syringe vacuum lipoaspiration, with emphasis on accessing adipose-derived mesenchymal/stromal stromal vascular fraction (SVF) aesthetic, structural reconstruction regenerative applications. Explain proven protocol high-quality fat grafts (AFG) disposable, microcannula systems. Design: components advantage...
Abstract Experimental autoimmune uveitis (EAU), in which CD4+ Th1 and/or Th17 cells are immunopathogenic, mimics various clinical features of noninfectious humans. The impact bromodomain extraterminal (BET) inhibitors on cell function was studied a mouse model EAU vivo and human vitro. Two BET (GSK151 JQ1) were able to ameliorate the progression inflammation T vitro, downregulating levels cells. Additionally, uveitogenic capacity transfer abrogated by an adoptive model. In cells, 5-d...
TGFβ/ALK5 pro-fibrotic signalling and herpesvirus infections have been implicated in the pathogenesis exacerbation of pulmonary fibrosis. In this study we addressed role during progression fibrosis a two-hit model MHV-68 infection on background pre-existing bleomycin-induced Assessment total lung collagen levels combination with ex vivo micro-computed tomography (µCT) analysis whole lungs, demonstrated that did not enhance deposition but led to persistent exacerbated inflammatory response....
A number of ultraviolet light-induced tumors that do not grow progressively in 3- or 9-month-old animals starting at approximately 15 months age. We investigated the immune response to one such tumor, 6130, young and old mice determine nature this breakdown protection with The 6130 tumor cells 22-month-old still retain sensitivity cytotoxic T lymphocytes (CTLs) generated against highly immunogenic "6130-A" antigen consequently are immunologically rejected when transplanted into animals, but...
<h3>Introduction</h3> Acute exacerbation (AE) of idiopathic pulmonary fibrosis (IPF) is defined as an episode acute respiratory worsening without identifiable aetiology. Herpes viruses infections have been implicated a possible cause AE in IPF. Moreover, herpes shown to act developmental cofactors and exacerbating agents experimental fibrosis. There growing evidence that the local activation coagulation cascade mediates potent profibrotic effects via proteinase activated receptors (PARs)...
<h3>Introduction</h3> Pulmonary fibrosis evolves in response to epithelial injury a number of lung diseases, and carries poor prognosis; novel therapies are urgently needed. The mitogen keratinocyte growth factor (KGF) has been shown prevent animal models however its therapeutic utility is limited by short half-life. There growing interest cell therapy approaches, we hypothesised that macrophages could be used as vehicles target KGF injured lung. <h3>Methods</h3> Lentiviral vectors...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHealth effects from radiationRobert E. AlexanderCite this: Environ. Sci. Technol. 1988, 22, 2, 144–145Publication Date (Print):February 1, 1988Publication History Published online12 August 2002Published inissue 1 February 1988https://pubs.acs.org/doi/10.1021/es00167a600https://doi.org/10.1021/es00167a600research-articleACS PublicationsRequest reuse permissionsArticle Views74Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the...