A5072007739- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Eosinophilic Disorders and Syndromes
- Lymphoma Diagnosis and Treatment
- Breast Lesions and Carcinomas
- Migration, Aging, and Tourism Studies
- Cell death mechanisms and regulation
- Lung Cancer Treatments and Mutations
- Breast Cancer Treatment Studies
- Radiomics and Machine Learning in Medical Imaging
- Geriatric Care and Nursing Homes
- Molecular Biology Techniques and Applications
- Cancer Genomics and Diagnostics
- Eosinophilic Esophagitis
- Microscopic Colitis
- HER2/EGFR in Cancer Research
- Cancer Research and Treatments
- Occupational Therapy Practice and Research
- Inflammatory Bowel Disease
- Breast Implant and Reconstruction
- Peptidase Inhibition and Analysis
- Lung Cancer Diagnosis and Treatment
- Cancer and Skin Lesions
- Tree-ring climate responses
St. James's Hospital
2011-2025
Trinity College Dublin
2020-2025
University College Cork
2015-2023
Children's Health Ireland at Crumlin
2022
Ollscoil na Gaillimhe – University of Galway
2018-2019
University Hospital Galway
2018
Galway Clinic
2018
Cork University Hospital
2009-2017
National University of Ireland, Maynooth
2017
St. Vincent's University Hospital
2012-2016
Background There is an urgent need to measure phosphorylated cell signaling proteins in cancer tissue for the individualization of molecular targeted kinase inhibitor therapy. However, phosphoproteins fluctuate rapidly following procurement. Snap-freezing preserves phosphoproteins, but unavailable most clinics and compromises diagnostic morphology. Formalin fixation histomorphology, penetrates slowly, unsuitable stabilizing phosphoproteins. We originated evaluated a novel one-step biomarker...
Incidence and prevalence of eosinophilic oesophagitis (EoE) may be increasing. Patients with fibrostenotic disease often present dysphagia, food bolus obstruction the inflammatory-predominant phenotype vomiting reflux [1]. Delayed diagnosis treatment correlate fibrosis [2]. Improved physician awareness could enable more timely diagnosis, reduce progression, thus associated complications, refractory poorer quality life. An Irish 2011 study indicated EoE was rare, noting an increasing referral...
The 2023/2024 storm season for the UK and Ireland was exceptionally wet as a whole, well ‘hosting’ notably large number of named storms, some which led to devastating flooding, with cascading impacts on human health, food production cost living.Here we present attribution study Oct-Mar season, quantifying role human-induced climate change frequency intensity strong winds heavy rainfall days total precipitation whole. severity index (SSI) is used identify stormy an...
The role of sentinel lymph node biopsy (SLNB) in ductal carcinoma situ (DCIS) is controversial. This study evaluates the risk clinically relevant SLN metastasis following a core needle (CNB) diagnosis pure DCIS.Cases that underwent SLNB CNB DCIS at our institution over 4.5 year period were evaluated. Parameters including characteristics on CNB, rate upstaging to invasive excision and result recorded.Of 296 patients with DCIS, 181 had (62%). invasion those undergoing was 30% (54/181)....
The Saint James's Hospital Biobank was established in 2008, to develop a high-quality breast tissue BioResource, as part of the cancer clinical care pathway. aims this work were: (1) ascertain quality RNA, DNA, and protein biobanked carcinomas normal tissues, (2) assess efficacy AllPrep(®) (Qiagen) isolating simultaneously, (3) compare AllPrep with RNEasy(®) QIAamp(®) (both Qiagen), (4) examine effectiveness Allprotect(®) (Qiagen), new stabilization medium preserving proteins. One hundred...
T cell infiltration into colorectal tumours has been shown to correlate with improved patient outcomes. However, more detailed information on the make-up and relationships between infiltrating subsets is lacking. We therefore correlated extent of immune frequencies various subsets. prospectively recruited 22 patients at time surgical resection for cancer. The Klintrup–Mäkinen (KM) score was used estimate tumours. CD4 CD8 cells that produced cytokines or expressed inhibitory molecule PD-1...
Summary Barrett’s esophagus (BE) is the main pathological precursor of esophageal adenocarcinoma (EAC). Progression to high-grade dysplasia (HGD) or EAC from nondysplastic BE (NDBE), low-grade (LGD) and indefinite for (IND) varies widely between population-based studies specialized centers many reasons, principally rigor biopsy protocol accuracy pathologic definition. In Republic Ireland, a multicenter prospective registry bioresource (RIBBON) was established in 2011 involving six academic...
Apoptosis triggered through the intrinsic pathway by radiation and anti-neoplastic drugs is initiated activation of caspase-9. To elucidate control mechanisms in this we used a range synthetic natural reagents. The inhibitory potency acetyl-Asp-Glu-Val-Asp-aldehyde ('Ac-DEVD-CHO'), benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone ('Z-VAD-FMK') endogenous caspase inhibitor X-chromosome-linked apoptosis protein ('XIAP') against recombinant caspase-9 were predictive efficacy these compounds...
We report on two cases of women trastuzumab therapy for breast cancer who became pregnant and delivered healthy live infants. At the time reporting children are growing developing normally (ages 3 2).
Background National standards for nursing homes in Ireland require that residents are offered a choice of recreational and stimulating activities to meet their needs preferences.
Abstract. A continuous 305-year (1711–2016) monthly rainfall series is created for the Island of Ireland. Two overlapping data sources are employed: i) a previously unpublished UK Meteorological Office note containing annual anomalies and corresponding proportional totals based on weather diaries early observational records period 1711–1977 and; ii) long-term, homogenised island Ireland 1850–2016. Using estimates long-term average precipitation from to merge these sources, new record...
Breast implant–associated lymphoma has recently gained wide recognition. Anaplastic large cell (ALCL) is the most frequently diagnosed subtype in this setting but spectrum broadening. A 66-year-old woman developed swelling and itch around her saline implant 6 years after its insertion. Imaging revealed a fluid collection surrounding with an adjacent mass. Microscopy showed sclerotic tissue punctuated by discrete cellular nodules comprising small lymphocytes, eosinophils interspersed atypical...
The development of acute lymphoblastic leukemia in an existing myeloproliferative neoplasm is rare with historical cases unable to differentiate between concomitant malignancies or leukemic transformation. Molecular studies coexisting JAK2 V617F-positive neoplasms and mature B cell indicate distinct disease entities arising myeloid lymphoid committed hematopoietic progenitor cells, respectively. Mutations CALR essential thrombocythemia appear be associated a phenotype lower risk thrombosis...
study we sought to determine whether colonic tissue OSM immunostaining, on biopsies from pretreatment endoscopies, had utility as a biomarker of IFX treatment outcome in hospitalized patients with corticosteroid-refractory ASUC.Patients admitted for management ASUC St James' s Hospital Dublin, Ireland between 2011 and 2017 were identified retrospectively.The diagnosis UC was made using established clinical, endoscopic histological criteria.Patients included where they received at least one...
We report the case of a 21 year old female with underlying facial lipodystrophy who presented left lower abdominal pain, weight gain and altered bowel habit.Subsequent investigation showed large (21cm×18cm×8cm) intraabdominal mass. At laparotomy, it was completely excised seen to arise from transverse mesocolon following histology revealed be mesenteric lipodystrophy.Mesenteric is rare clinical entity, part spectrum disorders sclerosing mesenteritis. This first reported in patient...
Abstract Background Approximately 1 in 5 older adults Ireland experience recurrent falls. Consequences of falls include functional decline, fear falling, reduced participation activities, hospitalisation and mortality (TILDA, 2017). Increased prevalence frailty related admissions was identified on this acute persons’ ward. Therapists found it increasingly difficult to provide comprehensive intervention given the ward’s quick turnover increasing caseloads. Methods A joint occupational therapy...