A5071955218- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- BRCA gene mutations in cancer
- Radiomics and Machine Learning in Medical Imaging
- Ion channel regulation and function
- RNA modifications and cancer
- Gestational Trophoblastic Disease Studies
- Colorectal and Anal Carcinomas
- Endometriosis Research and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Frailty in Older Adults
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Colorectal Cancer Surgical Treatments
- Sarcoma Diagnosis and Treatment
- Hip and Femur Fractures
- Enhanced Recovery After Surgery
- Renal and related cancers
- Cancer Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Ectopic Pregnancy Diagnosis and Management
- PARP inhibition in cancer therapy
St. James's Hospital
2020-2024
Trinity College Dublin
2021-2024
Queen's University Belfast
2013-2020
Belfast Health and Social Care Trust
2019-2020
The Northern Ireland Cancer Centre
2016-2019
NIHR Clinical Research Network
2019
University of Ulster
2019
Belfast City Hospital
2019
Cancer Trials Ireland
2017
Antrim Area Hospital
2010-2014
Objectives Surgical site infection (SSI) complicates 5% of all surgical procedures in the UK and is a major cause postoperative morbidity substantial drain on healthcare resources. Little known about incidence SSI its consequences women undergoing surgery for gynaecological cancer. Our aim was to perform first national audit following cancer through establishment UK-wide trainee-led research network. Design setting In prospective audit, we collected data from laparotomy suspected at 12...
The effect of the cyclo-oxygenase inhibitor, indomethacin, on hypothalamic-pituitary-adrenal function was investigated in five normal males. Baseline 0800 and 1600 h plasma ACTH cortisol, 11-deoxycortisol responses to metyrapone, cortisol dexamethasone exogenous were not affected by indomethacin. However, area under curve for after iv injection regular insulin (0.1 U/kg) significantly decreased during indomethacin administration (control, 88.0 ± 32.6 cm2, mean SD; 47.6 23.1, P < 0.01)....
<h3>Objectives</h3> The aim of this study was to investigate the relationship between BRCA1 and mitotic arrest deficiency protein 2 (MAD2) expression, as determined by immunohistochemistry, clinical outcomes in epithelial ovarian carcinoma (EOC). <h3>Methods</h3> A tissue microarray consisting 94 formalin-fixed paraffin-embedded EOC with fully matched clinicopathological data were immunohistochemically stained anti-BRCA1 anti-MAD2 antibodies. cores scored a semiquantitative manner evaluating...
Epithelioid trophoblastic tumours are rare neoplasms showing differentiation towards the chorion leave-type intermediate cytotrophoblast, with only a handful of cases being reported in literature. These slow-growing and typically confined to uterus for extended periods time. While pathogenesis is unclear, they thought arise from remnant trophoblast originating prior normal pregnancies or, less frequently, gestational tumours. A protracted time period between event tumour development typical....
The objective of this study was to investigate the relationship between BRCA1 protein expression, as determined by immunohistochemistry, and clinical outcome in uterine serous carcinoma (USC).A tissue microarray containing duplicate cores 73 cases USC immunohistochemically stained with mouse anti-BRCA1 (Ab-1) monoclonal (MS110) antibody. were scored a semiquantitative manner evaluating both distribution intensity nuclear staining. expression correlated progression-free survival.Seventy-two...
Key content The role of the Fanconi Anaemia‐ BRCA pathway in hereditary breast‐ovarian cancer syndrome. Recent research has led to identification further inherited mutations associated with ovarian carcinoma. improved knowledge mismatch repair a greater understanding how influence gynaecological cancer. Unusual carcinomas are often unusual germline mutations. Learning objectives An outline incidence, prevalence and inheritance patterns Discussion molecular mechanisms that interrupted due...
Endometrioid carcinoma with histopathologic resemblance to cutaneous pilomatrix mutations in the gene encoding beta-catenin, CTNNB1 are rare. There minimal numbers of reports high-grade tumors this divergent differentiation literature. We report case a 29-yr-old female an unusual presentation endometrial cancer overall histologic appearance indicative recently reported aggressive subtype Federation Gynecology and Obstetrics (FIGO) IVB grade 3 endometrioid features resembling carcinoma. She...
Introduction Older patients undergoing cancer surgery are at increased risk of post-operative complications, prolonged hospital stay, and mortality. Identification frailty can help predict high peri-operative complications allow a collaborative, multidisciplinary team approach to their care. A survey was conducted assess the confidence knowledge trainees in obstetrics gynecology regarding identification management issues encountered frail gynecological oncology patients. Methods web-based...
<h3>Introduction/Background</h3> Metastasis is the primary cause of cancer mortality. The migration tumour cells known as circulating (CTCs) in bloodstream form part 'liquid biopsy'. CTC enumeration serves prognostic marker breast, prostate, and colorectal cancers. However, due to technical challenges, its relevance epithelial ovarian carcinomas (EOC) remains limited. Therefore, we examined CTCs longitudinally serous non-serous EOCs. <h3>Methodology</h3> Peripheral blood samples were...
Frailty has been associated with worse cancer-related outcomes for people gynecological cancers. However, the lack of clear guidance on how to assess and modify frailty prior instigating active treatments potential lead large variations in practice outcomes. This study aimed evaluate current perspectives healthcare practitioners provision care patients a cancer.Data were collected via questionnaire-based survey distributed by Audit Research Gynecological Oncology (ARGO) collaborative...