A5086919968- Wound Healing and Treatments
- Urinary Tract Infections Management
- Bacterial Identification and Susceptibility Testing
- Dermatology and Skin Diseases
- Pediatric Urology and Nephrology Studies
- Gut microbiota and health
- Periodontal Regeneration and Treatments
- Congenital Diaphragmatic Hernia Studies
- Reconstructive Surgery and Microvascular Techniques
- Protease and Inhibitor Mechanisms
- Endometriosis Research and Treatment
- Frailty in Older Adults
- Pressure Ulcer Prevention and Management
- Neonatal Respiratory Health Research
- Burn Injury Management and Outcomes
- Tracheal and airway disorders
- Gynecological conditions and treatments
- Maternal and Perinatal Health Interventions
- Tumors and Oncological Cases
- Cardiac, Anesthesia and Surgical Outcomes
- Pelvic floor disorders treatments
- Diagnosis and Treatment of Venous Diseases
- Uterine Myomas and Treatments
- Planarian Biology and Electrostimulation
- Enhanced Recovery After Surgery
Royal Victoria Infirmary
2020-2023
Newcastle upon Tyne Hospitals NHS Foundation Trust
2020-2023
University of Manchester
2022
Freeman Hospital
2020
Wound Healing Society
2013
Abstract Background Current diagnoses of urinary tract infection (UTI) by standard urine culture (SUC) has significant limitations in sensitivity, especially for fastidious organisms, and the ability to identify organisms polymicrobial infections. The rate both SUC “negative” or “mixed flora/contamination” results UTI cases high prevalence asymptomatic bacteriuria indicate need an accurate diagnostic test help true cases. This study aimed determine if infection-associated biomarkers can...
A review of therapeutic effects in preclinical and clinical studies suggests that concordance between large animal (pig=78%), small laboratory (53%) vitro (57%) results with those observed humans is only partial. Pig models wound healing provide major advantages over other models. Since the vast majority wound-healing research done rodents vitro, low rate a significant impediment to will have any impact.To generate clinically relevant experimental data, hypothesis generation should begin, or...
The goal of this cross-sectional study was to characterize and describe persistent postburn pruritus. Cause treatment itch is elusive. It has been suggested that burn survivors with pruritus should be divided into acute (≤6 months postinjury) chronic (>6 because the cause may different. Cross-sectional data characteristics reported here are from baseline a prospective, randomized, double-blind, controlled pilot 23 subjects frequent bothersome Subjects self-completed validated scales for...
To compare histopathologic features of a fibroproliferative disorder in horses (exuberant granulation tissue-EGT) and people (keloid).Archival tissue samples EGT (n = 8) keloid (12).After automated hematoxylin eosin, histochemical (Gomori trichrome, Verhoeff-van Gieson elastin) immunohistochemical (vimentin, α-smooth muscle actin, CD34, CD68, CD117) stainings, sections were evaluated using semi-quantitative grading scale for presence or absence ulceration, keloidal collagen, myofibroblasts,...
The literature lacks consensus on the minimum microbial density required for diagnosing urinary tract infections (UTIs). This study categorized densities of urine specimens from symptomatic UTI patients aged ≥ 60 years and correlated them with detected levels immune response biomarkers neutrophil gelatinase-associated lipocalin (NGAL), interleukin-8 (IL-8), interleukin-1-beta (IL-1β). objective was to identify associated significant elevation these in order determine an optimal threshold...
Abstract: Given the growing impact of antimicrobial resistance, improvements in diagnosis and treatment most common outpatient infection, urinary tract infection (UTI), are great interest to stakeholders. Regulatory authorities have long accepted a microbial threshold 10 5 CFU/mL as standard for diagnosing UTI based on urine cultures. However, thresholds considered clinically relevant remain dispute. The aim this systematic scoping review is assess evidence supporting CFU/mL, guidelines,...
Standard urine culture (SUC) is the current standard method for confirmation of a urinary tract infection (UTI). SUC identifies microorganisms in samples and semi-quantifies these as colony-forming units (CFUs) ml-1. In contrast, quantitative multiplex polymerase chain reaction (q-MPCR) culture-independent assay which microbes are quantified by targeting genomic sequences reported cells ml-1, calculated from copies Using serial dilutions within 104-105 ml-1 range, usual reporting range SUC,...
We evaluated whether multiplex polymerase chain reaction (M-PCR) detects viable micro-organisms by comparing micro-organism identification with standard urine culture (SUC) and expanded quantitative (EQUC). Of the 395 organisms detected M-PCR, EQUC 89.1% (p = 0.10), whereas SUC 27.3% < 0.0001 vs. M-PCR p vs EQUC). identified 260 nonfastidious bacteria, 96.5% 0.68), 41.5% 0.0001). Common bacteria missed included Escherichia coli (72.5% detected), Klebsiella pneumoniae (66.7% Enterococcus...
Excessive levels of matrix metalloproteinases (MMPs) are present in chronic wounds preventing wound closure. Reducing detrimental components may be key healing wounds. Elta Protease-containing dressings have been observed clinically to resolve inflammation and appear aid acute recalcitrant To investigate possible mechanisms action, vitro tests, zymography, collagenase assays enzyme-linked immunosorbent (ELISAs), were performed evaluate the effect dressing proteases on beneficial such as...
Journal Article Double-Blind, Randomized, Pilot Study Assessing the Resolution of Postburn Pruritus Get access Bernadette Nedelec, BSc, OT, PhD, PhD *School Physical and Occupational Therapy, McGill University, Montreal, Quebec, Canada†Centre de recherche, Centre hospitalier l'Université Montréal, Canada‡Hôpital réadaptation Villa Medica, Canada **Address correspondence to Faculty Medicine, 3654 Promenade Sir William Osler, Québec, H3G 1Y5. Search for other works by this author on: Oxford...
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We aimed to determine if infection-associated urine biomarkers can differentiate true urinary tract infection (UTI) from non-UTI controls. Midstream clean-catch samples were collected asymptomatic volunteers and symptomatic subjects &gt; 60 years old diagnosed with presumptive UTI in a specialty setting. Microbial identification density assessed using multiplex PCR/pooled antibiotic susceptibility test (M-PCR/P-AST) standard culture (SUC). Three (NGAL, IL-8, IL-1β) measured the same...
Chronic wounds typically have excessive levels of matrix metalloproteinases (MMPs) and proinflammatory cytokines that impair healing. Reducing these detrimental proteins may be key to healing chronic wounds. Proprietary protease blends were formulated specifically degrade amounts factors could prevent wound Applications protease-containing dressings acute been observed clinically resolve inflammation appear aid The purpose this study was test in vitro a deliberate blend proteases for the...
Introduction Older patients undergoing cancer surgery are at increased risk of post-operative complications, prolonged hospital stay, and mortality. Identification frailty can help predict high peri-operative complications allow a collaborative, multidisciplinary team approach to their care. A survey was conducted assess the confidence knowledge trainees in obstetrics gynecology regarding identification management issues encountered frail gynecological oncology patients. Methods web-based...
Few chronic diseases carry such a personal and societal burden as endometriosis. Amultitude of symptoms similar to other various contributors the diseasecompounds its complexity perpetuates delay in diagnosis treatment. Thisliterature review consensus panel synthesized current research clinicalpractices develop clinical algorithm reduce symptoms, minimize time diagnosis,and improve patient quality life outcomes. Evaluating patients at earlier stagedendometriosis using best practice should...
There is emerging evidence of improved outcomes with induction labour for pregnancies in which the baby thought to be large. This trial identifies scan accuracy and effect intervention complicated by suspected large gestational age (LGA) on customized chart outside an academic center.
The literature lacks consensus on the minimum microbial density required for diagnosing urinary tract infections (UTIs). This study categorized densities of urine specimens from symptomatic presumptive UTI patients and correlated them with detected levels immune response biomarkers NGAL, IL-8, IL-1β. objective was to identify changes in at different determine an optimal threshold UTIs. Midstream clean-catch samples were analyzed identification quantification using SUC M-PCR, while IL-1β...
The Medical Certificate of Stillbirth (MCS) records data about a baby's death after 24 weeks gestation but before birth. Major errors that could alter interpretation the MCS were widespread in two UK-based regional studies.A multicentre evaluation was conducted, examining issued 1 January 2018 to 31 December 76 UK obstetric units. A systematic case-note review stillbirths conducted by Obstetric and Gynaecology trainees, generating individual 'ideal MCSs' comparing these actual issued....