A5084119142- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Genital Health and Disease
- Intraperitoneal and Appendiceal Malignancies
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer survivorship and care
- Appendicitis Diagnosis and Management
- Hepatocellular Carcinoma Treatment and Prognosis
- Reconstructive Surgery and Microvascular Techniques
- Reproductive tract infections research
- Corneal surgery and disorders
- Clinical practice guidelines implementation
- Crystallization and Solubility Studies
- Hernia repair and management
- Liver Diseases and Immunity
- Neuroendocrine Tumor Research Advances
- Nail Diseases and Treatments
- Glaucoma and retinal disorders
- Colorectal and Anal Carcinomas
- Urologic and reproductive health conditions
- Health Literacy and Information Accessibility
- Economic and Financial Impacts of Cancer
- Cholinesterase and Neurodegenerative Diseases
- Management of metastatic bone disease
University Hospital of Wales
2019-2025
Cardiff and Vale University Health Board
2023-2024
National Health Service
2022
Cardiff University
1993-2022
Indiana University School of Medicine
2020-2021
The University of Sydney
2018-2020
University of Cyprus
2020
Victoria University of Wellington
2020
University of Graz
2020
The University of Queensland
2020
BackgroundVulval intraepithelial neoplasia is a skin disorder affecting the vulva that, if left untreated, can become cancerous. Currently, standard treatment for patients with vulval surgery, but this approach does not guarantee cure and be disfiguring, causing physical psychological problems, particularly in women of reproductive age. We aimed to assess activity, safety, feasibility two topical treatments—cidofovir imiquimod—as an alternative surgery female neoplasia.MethodsWe recruited...
Over 50% of patients with ovarian cancer are diagnosed advanced disease (stage 3+) in Wales when treatment typically involves chemotherapy, combined cytoreductive surgery. Postoperative morbidity is common resulting prolonged hospital stays and delays returning to chemotherapy. Patients commonly have modifiable risk factors that can be targeted for improvement personalised prehabilitation. Multimodal prehabilitation has been shown a positive impact on perioperative outcomes length stay...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSyntheses, resolution, and structure-activity relationships of potent acetylcholinesterase inhibitors: 8-carbaphysostigmine analogsYuhpyng L. Chen, Jann Nielsen, Kirk Hedberg, Audrey Dunaiskis, Shawn Jones, Lorena Russo, Jonathan Johnson, Jeffrey Ives, Dane ListonCite this: J. Med. Chem. 1992, 35, 8, 1429–1434Publication Date (Print):April 1, 1992Publication History Published online1 May 2002Published inissue 1 April...
Epithelial ovarian cancer (EOC) is the deadliest gynaecological with high mortality rates driven by common development of resistance to chemotherapy. EOC frequently invades omentum, an adipocyte-rich organ peritoneum and omental adipocytes have been implicated in promoting disease progression, metastasis chemoresistance. The signalling mechanisms underpinning omentum tropism yet be elucidated.
Abstract Purpose: Response rates to treatment of vulval intraepithelial neoplasia (VIN) with imiquimod and cidofovir are approximately 57% 61%, respectively. Treatment is associated significant side effects and, if ineffective, risk malignant progression. response not predicted by clinical factors. Identification a biomarker that could predict an attractive prospect. This work investigated HPV DNA methylation as potential predictive in this setting. Experimental Design: from 167 cases VIN 3...
Topical cidofovir and imiquimod can effectively treat approximately 55% of patients with vulval intraepithelial neoplasia (VIN), thus avoiding the need for surgery. Human papillomavirus (HPV) E2 gene methylation predicts response to treatment but a measurement is only obtainable in 50% patients.
Introduction Inguino-femoral lymph node dissection plays a crucial role in the management of vulvar cancer. The procedure is associated with high complication rates, including infection, lymphocysts/lymphoedema and wound dehiscence. Several skin incision techniques exist practice among gynecology oncologists variable. Little evidence exists to guide surgeons regarding optimal surgical approach. This study aimed determine difference 30-day number nodes length stay between patients undergoing...
Introduction Older patients undergoing cancer surgery are at increased risk of post-operative complications, prolonged hospital stay, and mortality. Identification frailty can help predict high peri-operative complications allow a collaborative, multidisciplinary team approach to their care. A survey was conducted assess the confidence knowledge trainees in obstetrics gynecology regarding identification management issues encountered frail gynecological oncology patients. Methods web-based...
<h3>Introduction/Background</h3> Over 50% of ovarian cancer patients are diagnosed with advanced disease (stage 3+) in Wales (CRUK); treatment typically involves intense chemotherapy, combined cytoreductive surgery(Coleridge, Elsherbini, NICE) Surgery this nature is often complex and extensive physical psychological impact on the patient. Patients commonly have modifiable risk factors such as poor nutritional status that can be targeted for improvement personalised prehabilitation...
<h3>Introduction/Background</h3> In 2021 the National Institute for Clinical Excellence (NICE) published interventional procedures guidance stipulating that in UK, Pressurised IntraPeritoneal Aerosolised Chemotherapy (PIPAC) should only be used within context of a randomised control trial to demonstrate efficacy against standard care. The UK PIPAC collaborative would like present its first controlled assessing management peritoneal metastases (PM) patients with cancer colon, ovary and...
n N., Po w ell, N e d a Tris t r m , Am J. 2 0 1 7. H u P pillo vi s D NA h yl tio p dic o si g ci ofovi i mi q ui in Vulv al In pi eli pl 3. Clinic C c R 3 (1 8) . 5 4 6 0-5 8.
Objective: The objective of this study was to assess the ability American College Surgeons (ACS) NSQIP surgical risk calculator accurately identify patients at increased perioperative complication following surgery for gynaecological malignancy. Methods: A retrospective review 142 who underwent major under gynae-oncology team between 06/08/2018-16/04/2019 University Hospital Wales. Pre-operative factors combined with a procedure-specific code generated predicted 13 post-operative...
<h3>Introduction/Background</h3> A common treatment approach for patients with FIGO stage III/IV ovarian cancer is neoadjuvant chemotherapy (NACT) interval debulking surgery (IDS) subsequent adjuvant chemotherapy. However, not all undergo the intended multiple reasons. Outcome data these limited, however, reduced survival has been reported in literature. This study aimed to assess and compare oncological outcomes of who did IDS following NACT Wales. <h3>Methodology</h3> The Wales Cancer...
Background Vulvar cancer is a rare disease and despite broad adoption of sentinel lymph node mapping to assess groin metastases, inguino-femoral dissection still plays role in the management this disease. Inguino-femoral associated with high morbidity, limited research exists guide best surgical approach. Objective To determine international practice patterns key aspects technique provide data future research. Methods A survey addressing six domains performing was distributed internationally...
Twitter is the most frequently used social media platform by healthcare practitioners, at medical conferences. This study aimed to analyze conversations during virtual International Gynecological Cancer Society 2020 conference understand interactions between users related conference.Tweets using hashtag '#IGCS2020' were searched Search Application Programming Interface (API) period 10-13 September 2020. NodeXL Pro was retrieve data. The Clauset-Newman-Moore cluster algorithm clustered into...