A5053173421- Reproductive System and Pregnancy
- COVID-19 Clinical Research Studies
- Pregnancy and preeclampsia studies
- Maternal and fetal healthcare
- Endometriosis Research and Treatment
- Reproductive Biology and Fertility
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Intensive Care Unit Cognitive Disorders
- Birth, Development, and Health
- Gynecological conditions and treatments
- Respiratory Support and Mechanisms
- Ectopic Pregnancy Diagnosis and Management
- Ovarian function and disorders
- Gestational Diabetes Research and Management
- Advanced Breast Cancer Therapies
- Maternal and Perinatal Health Interventions
- Preterm Birth and Chorioamnionitis
- Cancer-related Molecular Pathways
- Cell Adhesion Molecules Research
- Epigenetics and DNA Methylation
- Protein Degradation and Inhibitors
- Ethics in Clinical Research
- Inflammatory mediators and NSAID effects
- Coronary Artery Anomalies
Swansea University
2009-2024
Cwm Taf University Health Board
2019-2024
Princess of Wales Hospital
2016-2024
Singleton Hospital
2008-2021
Swansea Bay University Health Board
2009-2021
Australia New Zealand Gynaecological Oncology Group
2019
General University Hospital of Patras
2005-2006
Royal Glamorgan Hospital
2004
Grigore T. Popa University of Medicine and Pharmacy
1993
BackgroundIn women with late preterm pre-eclampsia, the optimal time to initiate delivery is unclear because limitation of maternal disease progression needs be balanced against infant complications. The aim this trial was determine whether planned earlier initiation reduces adverse outcomes without substantial worsening neonatal or outcomes, compared expectant management (usual care) in pre-eclampsia.MethodsIn parallel-group, non-masked, multicentre, randomised controlled done 46 maternity...
Endometrium of fertile women expresses progesterone-regulated Mucin 1 (MUC1) that carries selectin ligands recognized by the human blastocyst. Altered MUC1 expression at time implantation may contribute to endometrial infertility.The aim was assess in endometrium from polycystic ovary syndrome (PCOS), endometriosis, and comparison with other hormone-regulated proteins [hydroxysteroid dehydrogenase (HSD) 1, HSD2, estrogen receptor (ER) progesterone (PR)].Endometrial samples were obtained 33...
During decidualization, human mesenchymal-like endometrial stromal cells undergo well characterized cellular and molecular transformations in preparation for accepting a developing embryo. Modulation of biophysical properties during decidualization is likely to be important receptivity support the embryo uterus. Here we assess including topography, roughness, adhesiveness stiffness undergoing vitro decidualization. A significant reduction cell surface roughness was observed following These...
L-selectin ligands, localized to the luminal epithelium at time of implantation, may support early stages blastocyst attachment. We have assessed expression two defined by MECA-79 and HECA-452 monoclonal antibodies, sulfotransferase GlcNAc6ST-2, involved in generation ligand epitopes, secretory phase endometrium from fertile infertile patients. Endometrial samples were obtained 33 fertile, 26 PCOS, 25 endometriosis patients diagnosed with unexplained infertility. ligands GlcNAc6ST-2 was...
Polycystic ovary syndrome (PCOS) is a common gynaecological disorder, with prevalence of up to 12% women reproductive age, and in part characterised by elevated circulating androgens aberrant expression androgen receptor (AR) the endometrium. A high percentage PCOS patients suffer from infertility, condition that appears be linked mistimed incomplete decidualisation critically affecting events surrounding embryo implantation. The aim this study was examine involvement MAGEA11, genome-wide...
Ovarian cancer diagnosis is currently based on imaging and circulating CA-125 concentrations with well-known limits to sensitivity specificity. New biomarkers are required complement testing increase effectiveness. Increases in of isotopic separation via multi collector inductively coupled plasma-mass spectrometry have recently allowed highly accurate measurement copper (Cu) variations. Studies breast patients revealed changes serum composition demonstrating the potential for development as...
Abstract Endometrial receptivity is mediated by adhesion molecules at the endometrium-trophoblast interface where osteopontin (OPN) and CD44 form a protein complex that plays an important role in embryo recognition. Here, we undertook prospective study investigating expression regulation of OPN 50 fertile 31 infertile ovulatory polycystic ovarian syndrome (PCOS) patients proliferative secretory phases natural menstrual cycle 12 anovulatory PCOS patients. biopsies blood samples were evaluated...
<h3>Background</h3> The treatment of endometrial cancer (EC), the most common gynecological cancer, is currently hampered by toxicity current cytotoxic agents, meaning novel therapeutic approaches are urgently required. <h3>Methods</h3> A cohort 161 patients was evaluated for expression receptor advanced glycation end products (RAGE) in tissues. present study also incorporates a variety vitro methodologies within multiple cell lines to evaluate RAGE and antibody-drug conjugate efficacy,...
Ovarian cancer (OC) is amongst the most lethal of common cancers in women. Lacking specific symptoms early stages, OC predominantly diagnosed late when disease has undergone metastatic spread and chemotherapy relied on to prolong life. Platinum-based therapies are preferred although many tumors respond initially, emergence platinum-resistance occurs majority cases after which prognosis very poor. Upregulation DNA damage pathways a feature platinum resistance with cyclin dependent kinases...
Endometrial cancer (EC) is the sixth most prevalent female globally and although high rates of success are achieved when diagnosed at an early stage, 5-year survival rate for cancers Stages II–IV below 50%. Improving patient outcomes will necessitate introduction novel therapies to clinic. Pan-cyclin-dependent kinase inhibitors (CDKis) have been explored as a range due their ability simultaneously target multiple key cellular processes, such cell cycle progression, transcription, DNA repair....
Ovarian cancer has a specific unmet clinical need, with persistently poor 5-year survival rate observed in women advanced stage disease warranting continued efforts to develop new treatment options. The amplification of BRD4 significant subset high-grade serous ovarian carcinomas (HGSC) led the development BET inhibitors (BETi) as promising antitumour agents that have subsequently been evaluated phase I/II trials. Here, we describe molecular effects and ex vivo preclinical activities...
Abstract Background Sialyl-Lewis X/L-selectin high affinity binding interactions between transmembrane O-glycosylated mucins proteins and the embryo have been implicated in implantation processes within human reproductive system. However, adhesive properties of these at endometrial cell surface are difficult to resolve due known discrepancies vivo models system a lack sensitivity current vitro models. To overcome limitations, an model epithelial was interrogated with single molecule force...
Epithelial ovarian cancer (EOC) is the deadliest gynaecological with high mortality rates driven by common development of resistance to chemotherapy. EOC frequently invades omentum, an adipocyte-rich organ peritoneum and omental adipocytes have been implicated in promoting disease progression, metastasis chemoresistance. The signalling mechanisms underpinning omentum tropism yet be elucidated.
Infections of the female reproductive tract are a major cause morbidity and mortality in humans, requiring significant investment to sustain treatment representing challenge health. The increasing prevalence bacterial resistance, an almost complete absence new antibiotic therapies for past five decades, mean there is desperate need novel approaches infections. Within present study, we demonstrate effective ex vivo infection using controlled-release, liquid crystal-based platform. Liquid...
Objectives To investigate whether women with overactive bladder (OAB) symptoms and no evidence of clinical infection by conventional clean-catch midstream urine cultures have alternative indicators sub-clinical infection. Patients/Subjects, Materials &amp; Methods The study was a prospective, blinded case-control 147 participants recruited, including 73 OAB patients 74 controls. group comprised female at least 18 years age who presented for more than 3 months. Clean-catch samples were...
SummarySymphysis fundal height (SFH) is currently used in the UK as a screening test to identify which pregnancies may require additional investigations including use of ultrasound fetal biometry. The routine SFH has been subjected extensive research assessing its sensitivity and also inter intraobserver variation. This study's aim was assess current practice measurement particularly looked at methods measurement. A total 250 healthcare professionals (doctors midwives) were asked complete...
The mechanical homeostasis of tissues can be altered in response to trauma or disease, such as cancer, resulting mechanotransduction pathways that have been shown impact tumor development, progression, and the efficacy therapeutic approaches. Specifically, ovarian cancer progression is parallel an increase tissue stiffness fibrosis. With vivo models proving difficult study, tying mechanics cellular molecular properties necessitate advanced, tunable, vitro 3D able mimic normal mechanic...
Abstract Background Epigenomic dysregulation has been linked to solid tumour malignancies, including ovarian cancers. Profiling of re-programmed enhancer locations associated with disease the potential improve stratification and thus therapeutic choices. Ovarian cancers are subdivided into histological subtypes that have significant molecular clinical differences, high-grade serous carcinoma representing most common aggressive subtype. Methods We interrogated landscape(s) normal ovary...
The mechanism of pre-eclampsia is still an enigma. There now some evidence that amniotic concentrations endothelin elevated in pregnancies associated with pre-eclampsia. aim this prospective observational study was to record the concentration fluid and compare women who develop do not Amniotic by second trimester later
Decidualisation, the process whereby endometrial stromal cells undergo morphological and functional transformation in preparation for trophoblast invasion, is often disrupted women with polycystic ovary syndrome (PCOS) resulting complications pregnancy and/or infertility. The transcription factor Wilms tumour suppressor 1 (WT1) a key regulator of decidualization process, which reduced patients PCOS, complex condition characterized by increased expression androgen receptor high presence...