A5059500970- Renal Diseases and Glomerulopathies
- Insect Utilization and Effects
- Chronic Kidney Disease and Diabetes
- Invertebrate Immune Response Mechanisms
- Insect behavior and control techniques
- Nitric Oxide and Endothelin Effects
- Complement system in diseases
- TGF-β signaling in diseases
- Insect Resistance and Genetics
- Research on Leishmaniasis Studies
- Nephrotoxicity and Medicinal Plants
- Aquaculture disease management and microbiota
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Parathyroid Disorders and Treatments
- Renal Transplantation Outcomes and Treatments
- Pregnancy and preeclampsia studies
- Insect and Pesticide Research
- Media Influence and Health
- Insect Pest Control Strategies
- Connective Tissue Growth Factor Research
- Smoking Behavior and Cessation
- Insect symbiosis and bacterial influences
- Renin-Angiotensin System Studies
- Escherichia coli research studies
- IL-33, ST2, and ILC Pathways
University of Patras
2007-2024
General University Hospital of Patras
2000-2006
Pediatric Nephrology of Alabama
2001
Transforming growth factor-beta(1) (TGF-beta(1)) is the major fibrogenic factor implicated in pathogenesis of renal scarring. Proteinuria a poor prognostic feature for various types glomerular disease and its toxic action may be related to activation tubular epithelial cells towards increased production cytokines chemoattractant peptides. In this work we studied site synthesis expression profile TGF-beta(1) tissue patients with heavy proteinuria examined relation urinary excretion...
Phagocytosis, melanization and nodulation in insects depend on phenoloxidase (PO) activity. In this report, we demonstrated that these three processes appear to be also dependent dopa decarboxylase (Ddc) Using flow cytometry, RNA interference, immunoprecipitation immunofluorescence, the constitutive expression of Ddc its strong association with haemocyte surface, medfly Ceratitis capitata. addition, showed Escherichia coli phagocytosis is markedly blocked by small interfering (siRNA) for...
The cellular and humoral factors involved in the development progression of renal scarring have not been fully investigated. Transforming growth factor-beta (TGF-beta(1)) is considered to be main fibrogenic factor it implicated pathogenesis fibrosis experimental clinical nephropathies. On other hand, collagen III an important component extracellular matrix. In this study we attempted identify any possible links between TGF-beta(1) synthesis expression with myofibroblasts evolution human...
• TiO 2 nanoparticle photo (370-410 nm)-excitation system (TiO 2-NP ) generates OH, O •− or both. substitutes the non-specifically OH-producing standard Fenton system. is used as generator of OH/O for oxidative biological simulations. The present study introduces a nanoparticle-based generation OΗ and upon visible photo-excitation, in order to be high stress simulations vitro . main novelties are: It set produce alone both (in contrast OΗ-based common use ), these options cover all possible...
Abstract Background Crescentic nephritis is characterized by formation of cellular crescents that soon become fibrotic and result in irreversible damage, unless an effective immunosuppressive therapy rapidly commenced. TGF-β 1 involved the development through various pathways. The aim this study was to identify whether determination urinary levels patients with crescentic could be used as a marker response treatment. Methods Fifteen were included study. renal expression estimated biopsy...
Abstract Chronic Kidney Disease (CKD) is characterized by immune activation with development of chronic inflammation. However, deficiency also exists in CKD patients. The number and the activity Natural Killer cells (NK-cells) are influenced biocompatibility various dialysis membranes. In this study we investigated effect modality membrane type on NK-cell phagocytic neutrophils patients different methods. Sixty were included divided three groups 20 each. Patients conventional hemodialysis...
Hydrogen peroxide (Η2Ο2) is produced during a variety of cellular procedures. In this paper, the regulatory role Η2Ο2, in Escherichia coli phagocytosis by human polymorphonuclears, was investigated. White blood cells were incubated with dihydrorhodamine (DHR) order to study H2O2 synthesis and E. coli-FITC phagocytosis. Flow cytometry revealed increased polymorphonuclears which incorporated coli-FITC. The blocking specific inhibitors, N-ethylmaleimide (ΝΕΜ) for NADPH oxidase...
Renal function is influenced by direct and indirect action of endothelins. They reduce renal blood flow glomerular filtration. The aim the present study was to determine plasma urinary endothelin-1 (ET-1) in two major categories patients compare them with normal subjects.Endothelin-1 measured urine chronic disease reduced filtration rate (GFR), proteinuria due dysfunction unaffected GFR. A group healthy subjects used as a reference.Plasma increased all 60 +/- 13 pg/ml independent GFR...
The pathophysiological pathways involved in the pathogenesis and evolution of renal fibrosis, have not been fully elucidated. Transforming growth factor-beta(1) (TGF-beta(1)) is development scarring. Apoptosis responsible for intrinsic cell deletion observed end-stage kidney disease. Myofibroblasts are fibrosis. This study investigates whether there a potential relationship between apoptosis, myofibroblast infiltration TGF-beta(1) expression patients with glomerulonephritis (GN).Forty...
Endothelin-1 (ET-1), which acts via the specific receptors ET-A and ET-B, has been implicated in development of renal scarring. The activation endothelin system was observed experimental models glomerular diseases attributed to toxic action proteinuria on tubular epithelial cells. aim this study investigate whether kidney is altered possibly related proteinuria.Thirty-seven patients with different types glomerulonephritis 14 controls were included. Patients presented either nephrotic...
To investigate the reason for increasing norepinephrine (NE) levels reported in continuous ambulatory peritoneal dialysis (CAPD) patients.Norepinephrine was measured plasma and dialysate of CAPD patients (n = 22) urine healthy subjects 20). It also with chronic renal failure (CRF) 15) on hemodialysis (HD) 15).It found that NE increased compared individuals (687+/-221 pg/mL vs 199+/-25 pg/mL, p < 0.01). The daily removal from peritoneum lower amount excreted subjects. Plasma after infusion...
Background. Apoptosis, a gene‐directed form of cell death, has been involved in the resolution renal injury but also development scarring. Bcl‐2 and bax are proteins related to apoptotic process that either provides survival advantage rapidly proliferating cells (bcl‐2) or promote death by apoptosis (bax). Various cytokines growth factors this process. This study investigates expression bcl‐2 presence bodies relation TGF‐β1 at time diagnosis biopsies patients with glomerulonephritis (GN)....
Cyclosporin-A (CsA) is often used in the treatment of nephrotic syndrome. The effectiveness CsA and value C2 blood levels syndrome, due to various glomerular diseases, were studied. Forty-two patients (M/F 21/21), with well-preserved renal function (creatinine clearance 87+/-20 ml/min) included study. original diagnoses minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN), IgA (IgAN), lupus nephritis (LN). All treated prednisolone for 24...