A5022250781- Nanoplatforms for cancer theranostics
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- Iron Metabolism and Disorders
- Nanoparticle-Based Drug Delivery
- Cancer Mechanisms and Therapy
- Advanced Breast Cancer Therapies
- Advanced Nanomaterials in Catalysis
- Cancer-related Molecular Pathways
Swansea University
2020-2022
Immunotherapy has yielded impressive results, but only for a minority of patients with cancer. Therefore, new approaches that potentiate immunotherapy are pressing medical need. Ferroptosis is newly described type programmed cell death driven by iron-dependent phospholipid peroxidation via Fenton chemistry. Here, we developed iron oxide-loaded nanovaccines (IONVs), which, chemically to integrate catalysis, drug delivery, and tracking exploiting the characteristics tumor microenvironment...
Endometrial cancer (EC) is the sixth most prevalent female globally and although high rates of success are achieved when diagnosed at an early stage, 5-year survival rate for cancers Stages II–IV below 50%. Improving patient outcomes will necessitate introduction novel therapies to clinic. Pan-cyclin-dependent kinase inhibitors (CDKis) have been explored as a range due their ability simultaneously target multiple key cellular processes, such cell cycle progression, transcription, DNA repair....
Abstract The efficacy of therapies is often hampered by limited tumor drug accumulation achieved through their intravenous administration, and the lack selectivity in targeting killing cancer cells. Amplification redox stress ferroptotic cell death to achieve selective cells using iron‐containing agents has attracted considerable interest. However, these need high doses multiple injection regimens have success treatment cancers such as melanoma. Melanoma metastasizes via lymphatic vessels,...