Sue Tohill
A5085619700- Pelvic floor disorders treatments
- Pregnancy and preeclampsia studies
- Pregnancy-related medical research
- Maternal and Perinatal Health Interventions
- Delphi Technique in Research
- Preterm Birth and Chorioamnionitis
- Neonatal Respiratory Health Research
- Maternal and fetal healthcare
- Urological Disorders and Treatments
- Anorectal Disease Treatments and Outcomes
- Pelvic and Acetabular Injuries
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Ethics in Clinical Research
- Abdominal Trauma and Injuries
- Cardiovascular Issues in Pregnancy
- Respiratory Support and Mechanisms
- Coronary Artery Anomalies
- Health Services Management and Policy
- Mobile Health and mHealth Applications
- Drug Transport and Resistance Mechanisms
- Powder Metallurgy Techniques and Materials
- Elasticity and Material Modeling
- Surgical Sutures and Adhesives
- Intensive Care Unit Cognitive Disorders
Guy's and St Thomas' NHS Foundation Trust
2022-2024
Saint Thomas West Hospital
2022
King's College London
2020
University Hospital Coventry
2013
University Hospitals Coventry and Warwickshire NHS Trust
2012-2013
University of Birmingham
2013
BackgroundIn women with late preterm pre-eclampsia, the optimal time to initiate delivery is unclear because limitation of maternal disease progression needs be balanced against infant complications. The aim this trial was determine whether planned earlier initiation reduces adverse outcomes without substantial worsening neonatal or outcomes, compared expectant management (usual care) in pre-eclampsia.MethodsIn parallel-group, non-masked, multicentre, randomised controlled done 46 maternity...
The accurate assessment and appropriate repair of birth related perineal trauma require high levels skill competency, with evidence based guideline recommendations available to inform UK midwifery practice. Implementation could reduce maternal morbidity associated trauma, which is commonly reported persistent, potential deter women from a future vaginal birth. Despite evidence, limited attention paid this important aspect We wished identify how midwives in the assessed repaired extent...
Perineal trauma during childbirth affects millions of women worldwide every year. The aim the Assessment and Repair Longitudinal Study (PEARLS) was to improve maternal clinical outcomes following through an enhanced cascaded multiprofessional training program support implementation evidence-based perineal management. This a pragmatic matched-pair cluster randomized controlled trial (RCT) that enrolled (n = 3681) sustaining second-degree tear in one 22 UK maternity units (clusters), organized...
Background Chronic or gestational hypertension complicates approximately 7% of pregnancies, half which reach 37 weeks’ gestation. Early term birth (at to 38 weeks) may reduce maternal complications, cesareans, stillbirths, and costs but increase neonatal morbidity. In the WILL Trial (When Induce Labour Limit risk in pregnancy hypertension), we aimed establish optimal timing for women with chronic who remain well. Methods findings This 50-centre, open-label, randomised trial United Kingdom...
Background Intrahepatic cholestasis of pregnancy, characterised by maternal pruritus and raised serum bile acid concentrations, is associated with increased rates stillbirth, preterm birth neonatal unit admission. Ursodeoxycholic widely used as a treatment, but without an adequate evidence base. Objective We aimed to evaluate whether or not ursodeoxycholic reduces adverse perinatal outcomes in affected women. Design Multicentre, masked, randomised, placebo-controlled, two-arm, parallel-group...
To address optimal timing of birth for women with chronic or gestational hypertension who reach term and remain well. Pragmatic, non-masked randomised trial. Inclusion: maternal age ≥16 years, hypertension, singleton pregnancy, live fetus, 36+0–37+6 weeks' gestation, able to give documented informed consent. Exclusion: contraindication either trial arm (e.g., pre-eclampsia another indication at term), blood pressure (BP) ≥ 160/110 mmHg until controlled, major fetal anomaly anticipated...
Abstract Background As a pragmatic randomised timing-of-birth trial, WILL adapted its trial procedures in response to the COVID-19 pandemic. These are reviewed here inform post-pandemic methodology. Methods The (internal pilot) paused March 2020, re-opened July and is currently recruiting 37 UK NHS consultant-led maternity units. We evaluated pandemic adaptations made processes surveyed sites for their views of these changes (20 sites, videoconference). Results Despite 88% favouring an...
In women with late preterm pre-eclampsia (i.e. at 34+0 to 36+6 weeks' gestation), the optimal delivery time is unclear because limitation of maternal-fetal disease progression needs be balanced against infant complications. The aim this trial was determine whether or not planned earlier initiation reduces maternal adverse outcomes without substantial worsening perinatal outcomes, compared expectant management, in pre-eclampsia. We undertook an individually randomised, triple non-masked...
<h3>Background</h3> Birth associated perineal trauma affects millions of women worldwide. The aim the Perineal Assessment and Repair Longitudinal Study (PEARLS) was to evaluate if an enhanced, cascaded training programme improved implementation evidence-based practise in assessment repair reduced subsequent maternal morbidity. <h3>Methods</h3> PEARLS a pragmatic matched pair cluster randomised controlled trial with 22 participating UK maternity units. Within each 11 pairs one unit receive...
Abstract Background : As a pragmatic randomised timing-of-birth trial, WILL adapted its trial procedures in response to the COVID-19 pandemic. These are reviewed here inform post-pandemic methodology. Methods The (internal pilot) paused March 2020, re-opened July and is currently recruiting 37 United Kingdom NHS consultant-led maternity units. We evaluated pandemic adaptations made processes, surveyed sites for their views of these changes (20 sites, videoconference). Results Despite 88%...
Objective To assess the diagnostic performance of angiogenic biomarkers in determining need for delivery seven days women with late preterm preeclampsia. Study design In a prospective observational cohort study 36 maternity units across England and Wales, we studied accuracy placental growth factor (PlGF) sFlt-1 risk complications requiring (34 +0 to +6 weeks' gestation) Angiogenic were measured using Quidel Roche (sFlt-1 : PlGF ratio) assays. Additional clinical data was obtained use within...
Background: In women with late preterm pre-eclampsia, the optimal time to initiate delivery is unclear because limitation of maternal disease progression needs be balanced against infant complications.The aim this trial was determine whether planned earlier initiation reduces adverse outcomes without substantial worsening neonatal or outcomes, compared expectant management (usual care) in pre-eclampsia.Methods: parallel-group, non-masked, multicentre, randomised controlled done
Aim There is currently limited evidence on the costs associated with late preterm pre-eclampsia beyond antenatal care and post-natal discharge from hospital. The aim of this analysis to evaluate 24-month cost-utility planned delivery for women at 34 +0 36 +6 weeks’ gestation compared expectant management an English National Health Service perspective using participant-level data PHOENIX trial. Methods Women between weeks' in 46 maternity units England Wales were individually randomised or...
Objective We evaluated the best time to initiate delivery in late preterm pre-eclampsia order optimise long-term infant and maternal outcomes. Design Parallel-group, non-masked, randomised controlled trial. Setting 46 UK maternity units. Population Women with between 34 +0 36 +6 weeks’ gestation, without severe disease, were planned or expectant management. Primary outcome Infant neurodevelopmental at 2 years of age, using PARCA-R (Parent Report Children’s Abilities-Revised) composite score....