A5089486059- Pregnancy and preeclampsia studies
- Traumatic Brain Injury Research
- Birth, Development, and Health
- Neonatal Respiratory Health Research
- Maternal and fetal healthcare
- Traumatic Brain Injury and Neurovascular Disturbances
- Preterm Birth and Chorioamnionitis
- Delphi Technique in Research
- Drug Transport and Resistance Mechanisms
- Cardiac Arrest and Resuscitation
- Advanced Neuroimaging Techniques and Applications
- Pediatric Hepatobiliary Diseases and Treatments
- Statistical Methods in Clinical Trials
- Ethics in Clinical Research
- Pregnancy and Medication Impact
- Liver Diseases and Immunity
- Cardiovascular Issues in Pregnancy
- Ectopic Pregnancy Diagnosis and Management
- Suicide and Self-Harm Studies
- Neurological Disease Mechanisms and Treatments
- Water resources management and optimization
- Assisted Reproductive Technology and Twin Pregnancy
- Gestational Diabetes Research and Management
- Health Systems, Economic Evaluations, Quality of Life
- Dementia and Cognitive Impairment Research
King's College London
2020-2024
Queen Charlotte's and Chelsea Hospital
2023
Imperial College London
2015-2023
Imperial Valley College
2020
Cognitive Neuroimaging Lab
2020
Hammersmith Hospital
2017-2019
University of Oxford
2018
Abstract Objectives To ascertain compliance rates with the European Commission’s requirement that all trials on EU Clinical Trials Register (EUCTR) post results to registry within 12 months of completion (final date 21 December 2016); identify features associated non-compliance; rank sponsors by compliance; and build a tool for live ongoing audit compliance. Design Retrospective cohort study. Setting EUCTR. Participants 7274 11 531 listed as completed EUCTR where could be established due....
Traumatic brain injury can reduce striatal dopamine levels. The cause of this is uncertain, but likely to be related damage the nigrostriatal system. We investigated pattern abnormalities using 123I-Ioflupane single-photon emission computed tomography (SPECT) scans and their relationship clinical features. studied 42 moderate-severe traumatic patients with cognitive impairments no motor parkinsonism signs 20 healthy controls. scanning was used assess transporter Clinical scan reports were...
Objective Trial registries are a key source of information for clinicians and researchers. While building OpenTrials, an open database public trial information, we identified errors omissions in registries, including discrepancies between descriptions the same different registries. We set out to ascertain prevalence completion status using cohort trials registered on both European Union Clinical Trials Register (EUCTR) ClinicalTrials.gov. Study design setting used matching titles registry...
Traumatic brain injury often produces executive dysfunction. This characteristic cognitive impairment causes long-term problems with behaviour and personality. Frontal lobe injuries are associated dysfunction, but it is unclear how these relate to corticostriatal interactions that known play an important role in behavioural control. We hypothesized dysfunction after traumatic would be abnormal interactions, a question has not previously been investigated. used structural functional MRI...
Abstract Cognitive impairment is common following traumatic brain injury. Dopaminergic drugs can enhance cognition after injury, but individual responses are highly variable. This may be due to variability in dopaminergic damage between patients. We investigate whether measuring dopamine transporter levels using 123I-ioflupane single-photon emission computed tomography (SPECT) predicts response methylphenidate, a stimulant with effects. Forty patients moderate-severe injury and cognitive...
Abstract Objective To quantify maternal hypertensive disorder of pregnancy (HDP) prevalence in late preterm and term infants admitted to neonatal units (NNU) assess opportunities avoid admissions. Design A retrospective population‐based study using the National Neonatal Research Database. Setting England Wales. Population Infants born ≥34 weeks’ gestation NNU between 2012 2020. Methods Outcomes HDP are compared with non‐HDP regression models. Main outcome measures Hypertensive pregnancy,...
Objective To evaluate whether a particular group of women with intrahepatic cholestasis pregnancy (ICP), based on their presenting characteristics, would benefit from treatment ursodeoxycholic acid (UDCA). Design Secondary analysis the PITCHES trial (ISRCTN91918806). Setting United Kingdom. Population or Sample 527 ICP. Methods Subgroup analyses were performed to determine baseline bile concentrations itch scores moderated woman’s response UDCA. Main outcome measures Bile concentration and...
Objective Traumatic brain injury (TBI) and rapid eye movement sleep behavioural disorder (RBD) are risk factors for Parkinson’s disease (PD). Dopaminergic abnormalities often seen after TBI, but patients usually lack parkinsonian features. We test whether PD RBD have distinct striatal dopamine using transporter (DaT) imaging. Methods 123 I-ioflupane single-photon emission CT scans were used in a cross-sectional study to measure DaT levels moderate/severe healthy controls, with early RBD....
ABSTRACT Objectives The objectives of this study were to (i) quantify the contribution maternal hypertensive disorders pregnancy (HDP) iatrogenic preterm birth (PTB) and neonatal unit (NNU) admissions < 34 +0 weeks (ii) describe short‐term population‐level outcomes for HDP infants, exploring ethnic disparities comparing by exposure. Design Retrospective population‐based using National Neonatal Research Database. Setting England Wales. Population Infants born admitted NNU 2012–2020....
The objective of this study was to explore and validate thresholds for Placental growth factor (PlGF) soluble fms-like tyrosine-kinase 1 (s-Flt-1) (as s-Flt-1: PlGF ratio), rule-in rule-out disease in women with suspected pre-eclampsia, using DELFIA® Xpress PlGF1-2-3 sFlt-1 assays.369 samples from or confirmed pre-eclampsia were analysed a prospective cohort study.Serum sFlt-1: quantified tests. Performances evaluated at established exploratory thresholds. Low concentration AUROC...
This secondary analysis of the PHOENIX trial (evaluating planned delivery against expectant management in late preterm preeclampsia) demonstrates that women who started induction labour, 63% delivered vaginally (56% at 34 weeks' gestation). Compared to management, was associated with higher rates neonatal unit admission for prematurity (but lower proportions small-for-gestational age infants); length stay and morbidity (including respiratory support) were similar across both intervention...
Pregnancy involves major adaptations in renal haemodynamics, tubular, and endocrine functions. Hypertensive disorders of pregnancy are a leading cause maternal mortality morbidity. Uromodulin is nephron-derived protein that associated with hypertension kidney diseases. Here we study the role urinary uromodulin excretion hypertensive pregnancy. Urinary was measured by ELISA 146 pregnant women treated chronic (n = 118) controls 28). We studied non-pregnant Wistar Kyoto Stroke Prone...
( BJOG. 2024;131:88–98. doi:10.1111/1471-0528.17574) It is essential to avoid unnecessary admission of infants neonatal units (NNU). Respiratory distress, infection, and hypoglycemia are common indications for the NNU a full-term neonate. Infants more likely be born preterm at risk if their mother diagnosed with hypertensive disorder during pregnancy (HDP). This study focused on quantifying extent which maternal HDP affects rates among ≥34 weeks’ gestation overall goal understanding where...
Serial neuropsychological testing potentially provides a powerful tool for tracking disease progress and identifying treatment response. Formal neuropsychometric assessment by clinical psychologist is ideal but impractical regular testing. Remote computerised resolves this difficulty allowing frequent home assessment, limited patient compliance practise effects. We study the feasibility of approach in an on-going trial investigating effects methylphenidate on cognition after traumatic brain...
In women with late preterm pre-eclampsia (i.e. at 34+0 to 36+6 weeks' gestation), the optimal delivery time is unclear because limitation of maternal-fetal disease progression needs be balanced against infant complications. The aim this trial was determine whether or not planned earlier initiation reduces maternal adverse outcomes without substantial worsening perinatal outcomes, compared expectant management, in pre-eclampsia. We undertook an individually randomised, triple non-masked...
Objective: To evaluate whether a particular group of women with intrahepatic cholestasis pregnancy would benefit from treatment ursodeoxycholic acid. Design: Secondary analysis the PITCHES trial (ISRCTN91918806). Setting: United Kingdom. Population or Sample: Women pregnancy. Methods: Subgroup analyses were performed to determine baseline bile acid concentrations itch scores moderated woman’s response Main Outcome Measures: Bile concentration and score. Results: In less than 40 μmol/L, UDCA...
<h3>Background</h3> Traumatic brain injury (TBI) causes dopaminergic disruption. The cause, however, is unclear and may relate to damage the nuclei or their ascending projections. <h3>Objectives</h3> To investigate whether: (1) TBI reduces striatal dopamine transporter (DAT) levels; (2) structural changes substantia nigra, striatum and/or nigrostriatal tract; (3) DAT levels following correlate with nigra tract damage. <h3>Methods</h3> 24 moderate/severe patients 13 controls underwent an...
Women are increasingly opting for expectant care of ectopic pregnancy to avoid surgical intervention and potentially safeguard future fertility. Robust prognostic markers predict which patients likely have successful conservative management few. The objective this study was investigate the biochemical sonographic characteristics with determine were predictive management. This retrospective cohort examined demographic details, routine biochemistry parameters all cases across a 24-month period...