A5089081365- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Colorectal and Anal Carcinomas
- Cancer-related Molecular Pathways
- Sarcoma Diagnosis and Treatment
- Glutathione Transferases and Polymorphisms
- Breast Lesions and Carcinomas
- Genital Health and Disease
- Cutaneous Melanoma Detection and Management
- Genomics, phytochemicals, and oxidative stress
- Estrogen and related hormone effects
- Dysphagia Assessment and Management
- Global Cancer Incidence and Screening
- Inflammatory mediators and NSAID effects
- COVID-19 and healthcare impacts
- Breast Cancer Treatment Studies
- Breast Implant and Reconstruction
- Male Breast Health Studies
- Nonmelanoma Skin Cancer Studies
- Reproductive tract infections research
- Congenital Anomalies and Fetal Surgery
- Pregnancy-related medical research
- Congenital Diaphragmatic Hernia Studies
- BRCA gene mutations in cancer
University Medical Center Groningen
2022
University of Groningen
2022
Singleton Hospital
2019-2021
Swansea Bay University Health Board
2019-2021
Queen Alexandra Hospital
2014
Royal Stoke University Hospital
1999-2009
University of Saint Mary
2007
St Mary's Hospital
2005
St. Mary's Hospital
2005
St Mary's Hospital
2005
The Groningen International Study on Sentinel nodes in Vulvar cancer (GROINSS-V)-II investigated whether inguinofemoral radiotherapy is a safe alternative to lymphadenectomy (IFL) vulvar patients with metastatic sentinel node (SN).GROINSS-V-II was prospective multicenter phase-II single-arm treatment trial, including early-stage (diameter < 4 cm) without signs of lymph involvement at imaging, who had primary surgical (local excision SN biopsy). Where the involved (metastasis any size), given...
As the few randomized controlled trials available in literature comparing botulinum toxin (BT) injection with established endoscopic treatment of achalasia cardia, i.e. pneumatic dilatation, showed conflicting results, we conducted a prospective trial. Seventeen consecutive patients cardia diagnosed during period between December 1997 and February 2000 were into two groups [pneumatic dilatation by Rigiflex dilator (n=10), BT sclerotherapy needle four quadrants lower esophageal sphincter...
The expression of cyclin D1 protein in tumour sections from 81 patients with epithelial ovarian cancer was analysed using immunohistochemistry. tumours that overexpressed more than 10% neoplastic cells were considered positive. Thus overexpression observed 72/81 (89%) the cases examined. Protein detected both nucleus and cytoplasm 24/81 (30%) localized exclusively 48/81 (59%) tumours. Cyclin borderline invasive There no association between stage differentiation. Furthermore, correlation...
The reliability and applicability of colposcopically directed cervical punch biopsy was assessed in a sample 170 paired large loop excision transformation zone (LLETZ) specimens obtained from previously untreated women who had been selected for treatment on the basis cytology and/or colposcopic findings whom entire visible. A single taken immediately before LLETZ, all were reviewed by pathologist. Nine (5.3%) biopsies inadequate. In terms whether or not there intraepithelial neoplasia (CIN),...
Ovarian cancer accounts for the majority of deaths from gynaecological malignancy, and polymorphisms in genes encoding glutathione-S-transferase (GST) GSTP1 detoxifying enzymes may lead to variation detoxification carcinogens. We describe a study involving 81 women with invasive epithelial ovarian cancer. A number important clinical variables outcome data were obtained. genotyping was undertaken using PCR-based techniques, expression quantified immunohistochemistry (IHC). Cox's proportional...
<h3>Introduction/Background</h3> <b>Introduction: </b>GROINSS-V II investigated whether radiotherapy is a safe alternative for inguinofemoral lymphadenectomy (IFL) in vulvar cancer patients with metastatic sentinel node (SN). <h3>Methodology</h3> <b>Methods:</b> In GROINSS-V II, prospective multicentre phase trial, were included early-stage squamous cell carcinoma (SCC) of the vulva (diameter <4cm) without suspicious lymph nodes at imaging, who had primary surgery SN-procedure. case SN...
EDITORIAL COMMENT": We accepted this paper for publication to remind readers of the different types nonobstetric trauma lower genital tract. The mechanism tearing in upper vagina during coitus is debated; report does not favour theory that unsupported results from levator spasm rather than direct injury (A). A. Ahnaimugan S, Asuen MI. Coital laceration vagina. Aust NZ J Obstet Gynaecol 1980; 20: 180–181. Summary: In a 4‐year‐period there were 31 admissions Nehru Hospital, because...
<h3>Background</h3> The treatment of endometrial cancer (EC), the most common gynecological cancer, is currently hampered by toxicity current cytotoxic agents, meaning novel therapeutic approaches are urgently required. <h3>Methods</h3> A cohort 161 patients was evaluated for expression receptor advanced glycation end products (RAGE) in tissues. present study also incorporates a variety vitro methodologies within multiple cell lines to evaluate RAGE and antibody-drug conjugate efficacy,...
Optimal management of the contralateral groin in patients with early-stage vulvar squamous cell carcinoma (VSCC) and a metastatic unilateral inguinal sentinel lymph node (SN) is unclear. We analyzed who participated GROINSS-V I or II to determine whether treatment can safely be omitted SN.We selected SN from databases. determined incidence additional non-SN metastases SN-metastasis underwent bilateral inguinofemoral lymphadenectomy (IFL). In those only ipsilateral no further treatment, we...
We have investigated the influence of CCND1 genotype on clinical outcome in 138 women with epithelial ovarian cancer. genotypes were identified from peripheral blood DNA by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis. Patient compared details including FIGO tumor stage, residual volume, histology and differentiation, response to chemotherapy, progression free interval, survival. observed no association between patient characteristics or...
The objective of this study was to determine whether the association between GSTM1 null/GSTTI null and survival in ovarian cancer is mediated by influence these genes on p53 expression. In 81 women with pure invasive cancer, GSTT1 genotypes were identified using polymerase chain reaction expression assessed immunohistochemistry. factors examined Cox's proportional hazards regression models. Performance status (P < 0.001), operative stage = 0.004), residual disease histologic subtype 0.05),...
Objective. This study assesses the role of preoperative serum CA125 levels in planning treatment options for women diagnosed with uterine cancer. Material and Method. Ninety five consecutive patients cancer during a four-year period were identified. Age ranged from 35 to 89 years mean age 69 years. The dichotomised at 28 U/mL (using ROC analysis identify best discriminating threshold 5-year survival). level was then correlated prognostic indicators: patient age, tumour grade,...
To examine the effect of COVID-19 pandemic on gonadorelin analogue prescription for community patients in England.We included data from all primary-care who had relevant prescriptions dispensed England. Descriptive statistics and interrupted time series analysis over 22 months (15 before 7 after lockdown) was evaluated.A total months' worth were analyzed (or 1 041 638 items, monthly average 47 347 items). Goserelin; leuprorelin, triptorelin are medicines most used by quantity study period....
In Brief Objective. To determine whether colposcopy is reliable in diagnosing cervical intraepithelial neoplasia women who have undergone a previous excision biopsy. Materials and Methods. A prospective study of attending the clinic at University Hospital North Staffordshire was performed between January 1998 December 1999. Results. clear histological diagnosis grade available for 469 treatment-naive group 58 treatment group. κ coefficients comparing colposcopic impression (negative,...
Objective To test the hypothesis that prilocaine with felypressin causes fewer side effects than lignocaine adrenaline when performing large loop excision of transformation zone cervix. Design Randomised trial. Setting Colposcopy clinic in a district general hospital. Participants Two hundred consecutive women undergoing Methods different local anaesthetic combinations (prilocaine and adrenaline) were compared zone. Prospective collection clinical treatment data was undertaken scoring using...
Endoscopic sclerotherapy (EST) leads to structural and motility changes in the esophagus; former are thought be commoner after EST with absolute alcohol (AA), which is a commonly used sclerosant India as it cheap effective. There no previous studies on esophageal AA. Accordingly, we studied patients portal hypertension before (n = 24) 22) variceal obliteration by AA using water perfusion manometry system. Contraction amplitude distal esophagus was reduced post-EST group compared pre-EST...
Sentinel node (SN) biopsy is widely applied for treatment planning of cutaneous melanoma. However, using this strategy in female lower genital tract tumors has not yet been established. We report two cases, one each vulvar and vaginal melanoma who underwent SN review the available literature. Our experience limited evidence suggests that low morbidity technique can be used obtaining prognostic information hence disease. a false negative rate perhaps order 15% careful consideration necessary...