A5019412820- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Global Maternal and Child Health
- Maternal Mental Health During Pregnancy and Postpartum
- Ovarian cancer diagnosis and treatment
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Pediatric Urology and Nephrology Studies
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Infant Nutrition and Health
- Ureteral procedures and complications
- Respiratory Support and Mechanisms
- Breastfeeding Practices and Influences
- Neonatal and fetal brain pathology
- Colorectal Cancer Treatments and Studies
- Kidney Stones and Urolithiasis Treatments
- Child and Adolescent Psychosocial and Emotional Development
- Renal and Vascular Pathologies
- Intraperitoneal and Appendiceal Malignancies
- Sarcoma Diagnosis and Treatment
- Child Nutrition and Water Access
- Gastric Cancer Management and Outcomes
- COVID-19 Impact on Reproduction
- Sexual Differentiation and Disorders
Singleton Hospital
2005-2025
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2022-2025
Research Network (United States)
2022-2025
Health and Human Development (2HD) Research Network
2025
Great Western Hospital
2025
Golisano Children's Hospital
2023-2024
University of Rochester Medical Center
2023-2024
Women & Children's Hospital of Buffalo
2023-2024
Clinical Trial Investigators
2024
Wrexham Maelor Hospital
2013-2023
Abstract Traffic light optimization is known to be a cost-effective method for reducing congestion and energy consumption in urban areas without changing physical road infrastructure. However, due the high installation maintenance costs of vehicle detectors, most intersections are controlled by fixed-time traffic signals that not regularly optimized. To alleviate at intersections, we present large-scale signal re-timing system uses small percentage trajectories as only input reliance on any...
Survival in stage I seminoma is almost 100%. Computed tomography (CT) surveillance an international standard of care, avoiding adjuvant therapy. In this young population, minimizing irradiation vital. The Trial Imaging and Surveillance Seminoma Testis (TRISST) assessed whether magnetic resonance images (MRIs) or a reduced scan schedule could be used without unacceptable increase advanced relapses.A phase III, noninferiority, factorial trial. Eligible participants had undergone orchiectomy...
Increased prenatal testosterone exposure has been hypothesized as a mechanism underlying autism spectrum disorders (ASD). However, no studies have prospectively measured and ASD. The current study sought to determine whether concentrations in umbilical cord blood are associated with clinical diagnosis of ASD small number children autistic-like traits the general population. Umbilical was collected from 707 children. Samples were analyzed for total (TT) bioavailable (BioT) concentrations....
There is now substantial evidence that autistic-like traits in the general population lie on a continuum, with clinical autism spectrum disorders (ASD) representing extreme end of this distribution. In study, we sought to evaluate five independently identified genetic associations ASD population. study cohort, phenotype and genomewide association genotype data were obtained from Western Australian Pregnancy Cohort (Raine) Study. The outcome measure used was Autism Spectrum Quotient (AQ),...
Abstract Colonic lipoma is a rare mesenchymal tumour of the gastrointestinal tract that composed well-differentiated adipose tissue (1). The commonest site colonic lipomas ascending colon (45%), followed by sigmoid (30.3%), descending (15.2%), and transverse (9.1%) (2). Lipomas large intestine represent third most common benign tumours after hyperplastic adenomatous polyps (3). They arise from submucosa in ~90% cases, but occasionally extend into muscularis propria; up to 10% are subserosal...
Over 50% of patients with ovarian cancer are diagnosed advanced disease (stage 3+) in Wales when treatment typically involves chemotherapy, combined cytoreductive surgery. Postoperative morbidity is common resulting prolonged hospital stays and delays returning to chemotherapy. Patients commonly have modifiable risk factors that can be targeted for improvement personalised prehabilitation. Multimodal prehabilitation has been shown a positive impact on perioperative outcomes length stay...
Group-based health services can improve maternal and newborn outcomes. Group antenatal care participatory learning action cycles (PLA) with women's groups have been cited by the WHO as systems interventions that lead to improvements in adherence outcomes pregnancy postpartum period.We used a mixed-methods approach assess feasibility of light touch group-based support intervention using WhatsApp text-messaging platform. Pregnant women were enrolled at Jacaranda Health (JH), maternity center...
Depression during pregnancy and in the postpartum period is associated with poor outcomes for women their children. Although effective interventions exist common mental disorders that occur period, most cases low- middle-income countries go untreated because of a lack trained professionals. Task-sharing models such as Thinking Healthy Program have shown potential feasibility efficacy trials strategy expanding access to treatment low-resource settings; however, there are significant barriers...
Background It is estimated that one third of maternal deaths in Kenya 2014 could have been prevented by more timely care-seeking. Mobile health interventions are increasingly being recognized as tools for the delivery education and promotion. Many occur first few weeks after mothers who given adequate care postpartum period better outcomes. Kiambu County, has a high level literacy phone ownership amongst delivering public hospitals was chosen site short message service intervention. Methods...
Research has proposed that autistic-like traits in the general population lie on a continuum, with clinical Autism Spectrum Disorder (ASD) representing extreme end of this distribution. Inherent proposal is biological mechanisms associated ASD may also underpin variation within population. A genome-wide association study using 2,462,046 single nucleotide polymorphisms (SNPs) was undertaken for 965 individuals from Western Australian Pregnancy Cohort (Raine) Study. No SNP associations reached...
Lactation and breast milk can hold great value meaning for grieving mothers who have experienced a recent death of an infant. Donation to human bank (HMB) as alternative discarding is one means respecting the milk. There little research, national policy discussion, or organizational representation in Australia on subject donation after infant death. On 29 November 2013 Mercy Hospital Women Melbourne, hosted Australia's first National Stakeholder Meeting (NSM) topic neonatal The NSM drew...
Background: Depression during pregnancy and in the postpartum period is associated with a number of poor outcomes for women their children. Although effective interventions exist common mental disorders that occur period, most cases low- middle-income countries go untreated because lack trained professionals. Task-sharing models such as Thinking Healthy Program have shown great potential feasibility efficacy trials strategy expanding access to treatment low-resource settings, but there are...
<h3>Objective</h3> Two randomized phase III trials demonstrated the efficacy and safety of combining bevacizumab with front-line carboplatin/paclitaxel for advanced ovarian cancer. The OSCAR (NCT01863693) study assessed impact bevacizumab-containing therapy on oncologic outcomes in patients cancer UK. <h3>Methods</h3> Between May 2013 April 2015, high-risk stage IIIB–IV received (7.5 or 15 mg/kg every 3 weeks, typically ≤12 months, per UK clinical practice) combined chemotherapy, continued...
Bisphosphonates and chemotherapy have increasingly gained favour in the treatment of metastatic hormone resistant prostate cancer. We investigated whether zoledronic acid, at a concentration found bone, would enhance anti-tumour activity docetaxel cancer cell line PC-3. Cells were exposed to acid (1 mM) combination or sequence with (3 nM). Cell viability, apoptosis markers for inhibition mevalonate pathway analyzed 48 72 hours after drug treatment. Reduction viability increased levels most...
To show that with a combination of evidence-based didactic and hands-on skill demonstration, pediatric interns will be able to correctly perform lumbar punctures (LPs) on neonates in the actual clinical setting.Twenty-three internal medicine/pediatric first year residents attended 1-hour course during their orientation. The consisted an presentation, reviewing anatomy, indications, complications, techniques for performing LPs, including video followed by practice LPs. All were anonymously...
We evaluate the efficacy and safety of metallic ureteric stenting using Cook Resonance® stent in treatment chronic obstruction benign malignant aetiology. Published experience this context is limited. add to body literature on topic.All patients who had a inserted between April 2009 November 2014 our institution were identified from prospectively maintained stent-database. Primary outcome was relief obstruction, defined by successful clinical radiological hydronephrosis/hydroureter....
Persistent human gastric infection with
Conducting clinical trials is often complex and involves many individuals from a variety of services, each with specific role in ensuring its successful implementation. Although an experienced trialist may anticipate the challenges, others be unexpected detrimental to completion study. We describe use simulation during preparation for initiation randomized trial new antiseizure medication neonates seizures. The process identification stakeholders roles, scenario development, challenges are...
Background Perinatal and newborn complications are major risk factors for unfavorable fetal neonatal outcomes. Gestational dating growth monitoring can be instrumental in the identification management of high-risk pregnancies births. The INTERGROWTH-21st Project developed first global standards gestational monitoring, supplying a toolkit clinicians. This study aimed to assess feasibility acceptability known implementation these low resource setting. Methods was performed two 12-month phases...
Benign prostatic hyperplasia (BPH) affects millions of men worldwide. The UroLift device was recently introduced as a means to perform urethral lift procedure for lateral lobe hypertrophy in patients with obstructive voiding symptoms, who would like avoid sexual and ejaculatory dysfunction.1 Crucially, Urolift has been associated failure rate 7% at 2 years 14% 4 years,2 the increasing popularity procedure, urologists should be prepared secondary procedures cases failure. Whilst high power...