A5035792596- Lymphoma Diagnosis and Treatment
- Ophthalmology and Eye Disorders
- Cancer Immunotherapy and Biomarkers
- Vestibular and auditory disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiovascular Syncope and Autonomic Disorders
- Immunotherapy and Immune Responses
- Urinary Tract Infections Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Abdominal Trauma and Injuries
- Childhood Cancer Survivors' Quality of Life
- Immune Cell Function and Interaction
- Cancer survivorship and care
- Meningioma and schwannoma management
- Pneumocystis jirovecii pneumonia detection and treatment
- Carbohydrate Chemistry and Synthesis
- Gut microbiota and health
- Neurogenesis and neuroplasticity mechanisms
- Medication Adherence and Compliance
- RNA regulation and disease
- Dietetics, Nutrition, and Education
- Food Security and Health in Diverse Populations
- Immune cells in cancer
- Cholesterol and Lipid Metabolism
- Glioma Diagnosis and Treatment
Mitchell Institute
2024
Texas A&M University
2018-2024
University of California, Irvine
2024
Torrey Pines Institute For Molecular Studies
2024
University of Utah
2023
Children's Hospital of Richmond at VCU
2023
Virginia Commonwealth University
2023
Loma Linda University
2023
University of Mississippi
2022
University Medical Centre Mannheim
2020-2021
Microglia replacement strategies are increasingly being considered for the treatment of primary microgliopathies like adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). However, available mouse models fail to recapitulate diverse neuropathologies reduced microglia numbers observed in patients. In this study, we generated a xenotolerant model lacking fms-intronic regulatory element (FIRE) enhancer within Csf1r, which develops nearly all hallmark pathologies...
Global population growth drives increasing food demand, which is anticipated to increase by at least 20% over the next 15 years. Rapid detection and identification of plant pathogens allows for up a 50% in total agricultural yield worldwide. Current molecular methods pathogen diagnostics, such as polymerase chain reaction (PCR), are costly, time-consuming, destructive. These limitations recently catalyzed push toward developing minimally invasive substrate general techniques that can be used...
DNA-encoded chemical library (DEL) technology provides a time- and cost-efficient method to simultaneously screen billions of compounds for their affinity protein target interest. Here we report its use identify novel series inhibitors the thioesterase activity polyketide synthase 13 (Pks13) from Mycobacterium tuberculosis (Mtb). We present three chemically distinct along with enzymatic Mtb whole cell potency, measure on-target in cells, crystal structures inhibitor-enzyme complexes...
We evaluated whether multiplex polymerase chain reaction (M-PCR) detects viable micro-organisms by comparing micro-organism identification with standard urine culture (SUC) and expanded quantitative (EQUC). Of the 395 organisms detected M-PCR, EQUC 89.1% (p = 0.10), whereas SUC 27.3% < 0.0001 vs. M-PCR p vs EQUC). identified 260 nonfastidious bacteria, 96.5% 0.68), 41.5% 0.0001). Common bacteria missed included Escherichia coli (72.5% detected), Klebsiella pneumoniae (66.7% Enterococcus...
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Accumulation of 7-ketocholesterol (7KC) occurs in age-related macular degeneration (AMD) and was found previously to promote fibrosis, an untreatable cause vision loss, partly through induction endothelial-mesenchymal transition. To address the hypothesis that 7KC causes mesenchymal transition retinal pigment epithelial cells (RPE), we exposed human primary RPE (hRPE) or a control. 7KC-treated hRPE did not manifest increased markers, but instead maintained RPE-specific proteins exhibited...
Abstract Background Natural cytokines are poorly suited as therapeutics for systemic administration due to suboptimal pharmacological and pharmacokinetic (PK) properties. Recombinant human interleukin-2 (rhIL-2) has shown promise treatment of autoimmune (AI) disorders yet exhibits short half-life opposing immune responses that negate an appropriate therapeutic index. Methods A semi-synthetic microbial technology platform was used engineer a site-specifically pegylated form rhIL-2 with...
Background: To evaluate the initial clinical experience with a surface image guided technique for stereotactic radiosurgery using minimal patient immobilization and real-time motion monitoring treatment of trigeminal neuralgia (TN). Methods: The study describes first seven TN patients treated this technique. Head positioning was achieved patient-specific head mold made out expandable foam that conforms to patient’s occiput. face each left open unobstructed maximal comfort. region interest...
Introduction Pembrolizumab (Keytruda) is a monoclonal antibody against the programmed cell death-1 (PD-1) receptor on lymphocytes, which one of immune checkpoint inhibitors (ICIs) approved for multiple solid and hematologic malignancies. Although ICIs have proven to be more effective less toxic compared chemotherapy, there are reports adverse side effects with ICIs. For example, pneumonitis potentially lethal effect occurring in 1%–5% patients who received clinical trials, case radiological...
Abstract Background The algorithmic approach to guidelines has been introduced and promoted on a large scale since the 1970s. This study aims at comparing performance of three algorithms for management chronic cough in patients with HIV infection, reassessing current position clinical decision making through an analysis accuracy, harm complexity. Methods Data were collected University Hospital Kigali (CHUK) total 201 HIV-positive hospitalised cough. We simulated each patient following...
The rectovaginal septum is a rare location for gastrointestinal stromal tumors (GIST) to occur. When such the case, question arises as whether lesion, which morphologically and immunophenotypically identical its counterpart, should be referred an extragastrointestinal tumor (EGIST). A 77-year-old, gravida 4, para 4004 post-menopausal female with unremarkable gynecologic history presented brown vaginal discharge. On examination, 4 5-cm nodule was palpated along septum. Ultrasound revealed...
Abstract Background Adult‐onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a rare human disease that caused by mutations in CSF1R, gene critical for the differentiation, proliferation, survival of microglia. ALSP patients typically develop dementia, motor impairments, seizures during their 30s or 40s. Upon autopsy, patients’ brains exhibit decreased numbers microglia, white matter atrophy, astrocytosis, spheroids, enlarged ventricles, calcification. Two recent...
Abstract Introduction: Pediatric patients diagnosed with cancer report lower quality of life and increased psychological distress. Furthermore, African American pediatric oncology face unique extensive obstacles upon diagnosis. The present study sought to identify patient-centered experiences following a diagnosis in sample patients. Methods: This examined semi-structured interviews (N = 13; Mage 13.54 years; 7-17 years). Interviews were audio recorded transcribed. Response patterns...
Aldesleukin is a recombinant form of IL-2 approved for metastatic melanoma and renal cell carcinoma that induced complete, durable remissions in certain patients. Yet, its use infrequent because vascular leak syndrome (VLS), severe dose-limiting adverse event stemming from the engagement high affinity receptor (IL-2R) alpha chain type 2 innate lymphoid cells, eosinophils endothelial cells. THOR-707 site-directed, singly pegylated completely lacking IL-2R yet retaining normal binding to...
Case Report A 76-year-old female patient experiences a fall after months of diplopia and gelatinous rhinorrhoea The negated epistaxis, hyposmia B symptoms.
Fallbericht Eine 76-jährige Patientin stellt sich aufgrund eines Sturzereignis notfallmäßig mit seit Monaten bestehender Diplopie und gallertartiger Rhinorrhoe vor. Die verneint eine Epistaxis, Hyposmie sowie B-Symptomatik.