Background: Opioid analgesics remain a mainstay in the treatment of pain associated with surgical procedures. Such use is adverse drug events (ADEs). Objective: To investigate impact opioid-related ADEs on total hospital costs and length stay (LOS) adult patients. Methods: This was retrospective matched cohort study using data from computerized medical records. ADE cases were prospectively detected surveillance verified by pharmacists. Surgical patients treated at LDS Hospital Salt Lake City...

Background— Bleeding is an important cause of morbidity and mortality in patients with continuous-flow left ventricular assist devices (LVADs). Reduced pulsatility has been implicated as a contributing cause. The aim this study was to assess the effects different degrees on incidence nonsurgical bleeding. Methods Results— Utah Transplantation Affiliated Hospitals (U.T.A.H.) heart failure transplant program databases were queried for end-stage who required support LVAD HeartMate II (Thoratec...

<h3>Importance</h3> Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect of neurotoxic chemotherapy resulting in pain, sensory loss, and decreased quality life. Few studies have prospectively examined the relationship between symptoms, falls, fall-related injuries for patients receiving chemotherapy. <h3>Objective</h3> To determine association symptoms CIPN risk falls <h3>Design, Setting, Participants</h3> In this secondary analysis prospective study, 116 with breast,...

In the United States, more intrauterine device (IUD) users select levonorgestrel IUDs than copper for long-term contraception. Currently, clinicians offer only emergency contraception because data are lacking on efficacy of IUD this purpose.This randomized noninferiority trial, in which participants were unaware group assignments, was conducted at six clinics Utah and included women who sought after least one episode unprotected intercourse within 5 days before presentation agreed to...

Purpose: The purpose of this work was to evaluate the image quality a commercial CT scanner equipped with novel detector and filtration technology called PureVision Optics (PVO). Methods: number, noise, contrast-to-noise ratio (CNR), modulation transfer function (MTF), noise power spectrum (NPS) were assessed using ACR Accreditation phantom scanned various acquisitions at 80 kV, 100 120 135 each multiple CTDI vol values 20 mGy, 40 65 mGy. Artifacts evaluated in an anthropomorphic head...

Background: Delamination of acetabular articular cartilage is a common abnormality in hips with femoroacetabular impingement. The purpose the present study was to identify clinical and radiographic factors predisposing delamination assess diagnostic accuracy magnetic resonance arthrography for detection these lesions. Methods: Following retrospective review records, we determined that had been twenty-eight sixty-four undergone surgical dislocation procedure treatment Multivariable logistic...

Use of the heptavalent pneumococcal conjugate vaccine (PCV-7 [Prevnar]) has been associated with decreased a incidence invasive disease (IPD) among children in United States.Cases IPD < 18 years age insured by or receiving health care from Intermountain Health Care during 1996-2003 were identified. Isolates S. pneumoniae treated at Primary Children's Medical Center (PCMC; Salt Lake City, UT) 1997-2003 serogrouped. Temporal trends IPD, serogroup distribution pneumococci, and antibiotic...

ContextThe impact of clinical decision support systems (CDSS) on antimicrobial prescribing in ambulatory settings has not previously been evaluated.ObjectiveTo measure the added value CDSS when coupled with a community intervention to reduce inappropriate drugs for acute respiratory tract infections.Design, Participants and SettingCluster randomized trial that included 407 460 inhabitants 334 primary care clinicians 12 rural communities Utah Idaho (6 1 shared characteristic 6 another), third...

Opioids are used increasingly in the management of moderate-to-severe chronic non-cancer pain (CNCP). Opioid-induced bowel disorders (OBD) markedly impact health-related quality life (HRQoL) and frequently limit medically indicated opioid pharmacotherapy. We assessed risk factors, effect OBD on HRQoL CNCP patients. also estimated likely prevalence narcotic syndrome (NBS). These effects have been reported cancer patients but not previously.Ambulatory (n = 146) taking regularly scheduled...

Background: The purpose of this study was to compare the outcomes surgical treatment in children walking age with unilateral and bilateral developmental dysplasia hip (DDH). Methods: We examined records fifty-six 156 treated open reduction pelvic osteotomy or without femoral from 1990 2000. minimum duration follow-up five years. mean at surgery thirty-four months group twenty-five group. Preoperative radiographs were evaluated determine Tönnis grade dislocation acetabular index, latest...

Increased age, larger tear size, and more advanced fatty degeneration of the rotator cuff musculature have been correlated with poorer healing rates after repair. Platelets are an endogenous source growth factors present during healing.Augmentation repairs platelet-rich fibrin matrix (PRFM) may improve biology thus functional outcome scores retear repair.Cohort study; Level evidence, 3.Rotator tears at risk for were prospectively identified using algorithm; points assigned age (50-59 years =...

To describe the results of two reliability studies and to assess effect training on interrater scores.

Late preterm infant mortality is higher than that for term newborns. The association between weight gestational age (WGA) category and late has not been well described.Our objectives this research were as follows: (1) to compare neonatal rates of SGA, AGA, LGA preterm, early term, newborns; (2) determine the relative risk death each WGA category; (3) examine causes death.We reviewed linked birth certificate data all infants from Utah born 1999 2005 with a GA > or =34 weeks. We calculated...

To describe the proportion of children screened by Modified Checklist for Autism in Toddlers (M-CHAT), identify characteristics associated with screen completion, and examine associations between autism spectrum disorder (ASD) screening later ASD diagnosis.We examined data from attending 18- 24-month visits 2013 2016 20 clinics within a health care system evidence M-CHAT subsequent coding diagnosis at age >4.75 years. We interviewed providers information about usual methods scoring...

Dietary iron supplementation is associated with increased appetite. Here, we investigated the effect of on hormone leptin, which regulates food intake and energy homeostasis. Serum ferritin was negatively serum leptin in a cohort patients metabolic syndrome. Moreover, same inverse correlation observed mice fed high-iron diet. Adipocyte-specific loss exporter ferroportin resulted loading decreased while levels hepcidin murine hereditary hemochromatosis (HH) model adipocyte expression, iron,...

Background and purpose Blood pressure variability has been found to contribute worse outcomes after intravenous tissue plasminogen activator, but the association not established intra-arterial therapies. Methods We retrospectively reviewed patients with an ischemic stroke treated therapies from 2005 2015. was measured as standard deviation (SD), coefficient of variation (CV), successive (SV). Ordinal logistic regression models were fitted outcome modified Rankin Scale (mRS) univariable...

Use of empirical broad-spectrum antibiotics for pneumonia has increased owing to concern resistant organisms, including methicillin-resistant Staphylococcus aureus (MRSA). The association anti-MRSA therapy with outcomes among patients is unknown, even high-risk patients.

Previous studies showed that sicker patients were initiated on dialysis at higher GFR as estimated by the Modification of Diet in Renal Disease (MDRD) formula. It was previously shown with low creatinine production malnourished and had serum levels clearances (CrCl) but high MDRD initiation dialysis. Therefore, a propensity score approach used to examine associations measured CrCl subsequent mortality. Baseline data outcomes obtained from Dialysis Morbidity Mortality Study Wave II....

BACKGROUND Many adverse drug events (ADEs) are the result of known pharmacologic properties, and some from medication errors. However, patient-specific risk factors. OBJECTIVE To identify inpatient factors for ADEs. METHODS Conditional logistic regression was used to analyze all pharmacist-verified ADEs by therapeutic class drugs severity during a 10-year study period. All inpatients ≥18 years age 520-bed tertiary teaching hospital were included. Each case patient matched with up 16 control...

ABSTRACT. This study examined the validity and clinical implications of assumption Modification Diet in Renal Disease Study (MDRD) formula that age, gender, race, BUN account for creatinine production (CP). The relationships MDRD GFR, CP, nutrition were 1074 Dialysis Morbidity Mortality Wave II patients with reported measured clearances at initiation dialysis. Age, BUN, serum (Scr) used to calculate GFR. 24-h urinary was estimate CP. In linear regression, Scr positively correlated CP...

OBJECTIVES. The purpose of this work was to determine the relative risk for mortality and causes ages death late-preterm newborns (gestational age 34–36 weeks) compared with those born at term. METHODS. We reviewed data from birth certificates infants in Utah between 1999 2004. calculated early neonatal (first week), 28 days), infant year) rates each weekly estimated gestational cohort 34 42 weeks and, using 40 as reference, ratios cohort. Causes were grouped into 8 categories near term...

Regions of hypoxia within glioblastoma multiforme (GBM) are common and may influence a tumor's aggressiveness, response to treatment, the patient's overall survival. In this study, authors examined 4 markers (hypoxia-inducible factor 1 [HIF-1alpha], glucose transporter [GLUT-1], vascular endothelial growth [VEGF], carbonic anhydrase 9 [CA IX]), cellular proliferation microvascular density (MVD) indices, extent surgical resection, preoperative imaging characteristics compared them with...