A5055898876- Venous Thromboembolism Diagnosis and Management
- Patient Safety and Medication Errors
- Central Venous Catheters and Hemodialysis
- Ultrasound in Clinical Applications
- Sepsis Diagnosis and Treatment
- Emergency and Acute Care Studies
- Nosocomial Infections in ICU
- Cardiac, Anesthesia and Surgical Outcomes
- Atrial Fibrillation Management and Outcomes
- Heart Failure Treatment and Management
- Healthcare Technology and Patient Monitoring
- Radiation Dose and Imaging
- Opioid Use Disorder Treatment
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- Pharmaceutical Practices and Patient Outcomes
- Substance Abuse Treatment and Outcomes
- Electronic Health Records Systems
- Pharmacovigilance and Adverse Drug Reactions
- Lung Cancer Diagnosis and Treatment
- Patient Satisfaction in Healthcare
- Acute Myocardial Infarction Research
- Pneumonia and Respiratory Infections
- Health Systems, Economic Evaluations, Quality of Life
- Anesthesia and Pain Management
Intermountain Healthcare
2014-2024
Aneurin Bevan University Health Board
2022-2024
Rutgers, The State University of New Jersey
2021-2024
Rutgers Sexual and Reproductive Health and Rights
2023
Intermountain Medical Center
2014-2022
Royal Gwent Hospital
2022
University of Utah
2001-2019
Cardiff University
2016
LDS Hospital
1998-2014
Brigham and Women's Hospital
2012
Optimal decisions about the use of antibiotics and other antiinfective agents in critically ill patients require access to a large amount complex information. We have developed computerized decision-support program linked computer-based patient records that can assist physicians improve quality care. This presents epidemiologic information, along with detailed recommendations warnings. The recommends regimens courses therapy for particular provides immediate feedback. prospectively studied...
Abstract Thrombotic antiphospholipid syndrome (TAPS) is characterized by venous, arterial, or microvascular thrombosis. Patients with TAPS merit indefinite anticoagulation, and warfarin has historically been the standard treatment. Apixaban an oral factor Xa inhibitor anticoagulant that requires no dose adjustment monitoring. The efficacy safety of apixaban compared for patients remain unknown. This multicenter prospective randomized open-label blinded endpoint study assigned anticoagulated...
Ventilator-associated pneumonia (VAP) surveillance is time consuming, subjective, inaccurate, and inconsistently predicts outcomes. Shifting from in particular to complications general might circumvent the VAP definition's subjectivity inaccuracy, facilitate electronic assessment, make interfacility comparisons more meaningful, encourage broader prevention strategies. We therefore evaluated a novel paradigm for ventilator-associated (VAC) defined by sustained increases patients' ventilator...
Objectives: The subjectivity and complexity of surveillance definitions for ventilator-associated pneumonia preclude meaningful internal or external benchmarking therefore hamper quality improvement initiatives ventilated patients. We explored the feasibility creating objective pneumonia. Design: identified clinical signs suitable inclusion in definitions, proposed candidate incorporating these signs, then applied to retrospective data measure their frequencies associations with adverse...
Background: Antiphospholipid syndrome (APS) is an acquired thrombophilia characterized by thrombosis, pregnancy morbidity, and the presence of characteristic antibodies. Current therapy for patients having APS with a history thrombosis necessitates anticoagulation vitamin K antagonist warfarin, challenging drug to manage. Apixaban, approved treatment prevention venous low rate bleeding observed, has never been studied among APS. Aims Methods: We report study rationale design Apixaban...
To compare clinical outcomes in a randomised comparison of treatment with danaparoid sodium (a heparinoid), or dextran 70, for heparin-induced thrombocytopaenia (HIT) plus thrombosis.Forty-two patients recent thrombosis and diagnosis probable HIT who presented at ten Australian hospitals during study period six one half years were randomly assigned to open-label intravenous each combined oral warfarin. Thirty-four (83%) had positive platelet aggregation 14C-serotonin release test antibody....
BACKGROUND Many adverse drug events (ADEs) are the result of known pharmacologic properties, and some from medication errors. However, patient-specific risk factors. OBJECTIVE To identify inpatient factors for ADEs. METHODS Conditional logistic regression was used to analyze all pharmacist-verified ADEs by therapeutic class drugs severity during a 10-year study period. All inpatients ≥18 years age 520-bed tertiary teaching hospital were included. Each case patient matched with up 16 control...
Although adverse drug events have been extensively evaluated by computer-based surveillance, medical device errors no comparable surveillance techniques.To determine whether can reliably identify device-related hazards (no known harm to patient) and (AMDEs; patient experienced harm) compare alternative methods of detection problems.This descriptive study was conducted from January through September 2000 at a 520-bed tertiary teaching institution in the United States with experience using...
(See the Editorial Commentary by Magill and Fridkin, on pages 378–80.) Background. The complexity subjectivity of ventilator-associated pneumonia (VAP) surveillance limit its value in assessing comparing quality care for ventilated patients. A simpler, more quantitative VAP definition may increase utility. Methods. We streamlined Centers Disease Control Prevention to objectivity efficiency. Qualitative criteria were replaced with criteria, changes ventilator settings used screen patients...
Abstract Objective Develop and evaluate an automated identification predictive risk report for hospitalized heart failure (HF) patients. Methods Dictated free-text reports from the previous 24 h were analyzed each day with natural language processing (NLP), to help improve early of patients HF. A second application that uses Intermountain Healthcare-developed score determine HF patient’s 30-day hospital readmission mortality was also developed. That information included in report, which...
Abstract Objective Develop and evaluate an automated case detection response triggering system to monitor patients every 5 min identify early signs of physiologic deterioration. Materials methods A 2-year prospective, observational study at a large level 1 trauma center. All admitted 33-bed medical oncology floor (A) non-intensive care unit (ICU) surgical (B) were monitored. During the intervention year, pager alerts deterioration automatically sent charge nurses along with access graphical...
Antibiotic use and misuse is driving drug resistance. Much of US healthcare takes place in small community hospitals (SCHs); 70% all have <200 beds. SCHs poorly described. We evaluated antibiotic using data from the National Healthcare Safety Network antimicrobial option Centers for Disease Control Prevention. used Intermountain Healthcare's monthly reports 19 2011 to 2013. Hospital care units were categorized as intensive care, medical/surgical, pediatric, or miscellaneous. Antibiotics...
Data on sepsis prevalence the general wards is lacking UK and in developed world. We conducted a multicentre, prospective, observational study of patients with or severe Emergency Departments (ED) Wales. During 24-hour period all NEWS≥3 were screened for presence 2 more SIRS criteria. To be eligible inclusion, had to have high clinical suspicion an infection, together systemic inflammatory response (sepsis) evidence acute organ dysfunction and/or shock (severe sepsis). There 5317 in-patients...
A retrospective 9-year cohort study was conducted to identify the hospitalization costs, length of hospital stay, and mortality associated with nephrotoxicity (NT) among 494 inpatients who were treated conventional amphotericin B (CAB). Survival regression methods used model effect NT. The rate NT 12%; overall in-hospital 22%. After adjustment for confounding, a 2.7-fold higher risk death (P<.001). Although unadjusted effects on stay costs after initiation CAB consistent small increases,...