A5085590104- Assisted Reproductive Technology and Twin Pregnancy
- Birth, Development, and Health
- Reproductive Biology and Fertility
- Pregnancy and preeclampsia studies
- Ovarian function and disorders
- Gestational Diabetes Research and Management
- Neonatal Respiratory Health Research
- Reproductive Health and Technologies
- Ectopic Pregnancy Diagnosis and Management
- COVID-19 Impact on Reproduction
- Endometriosis Research and Treatment
- Trauma and Emergency Care Studies
- Maternal and Perinatal Health Interventions
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Maternal and fetal healthcare
- Fatty Acid Research and Health
- Prenatal Screening and Diagnostics
- Simulation-Based Education in Healthcare
- Bone health and treatments
- Cancer Risks and Factors
- Pregnancy-related medical research
- Frailty in Older Adults
- Menstrual Health and Disorders
Princess Anne Hospital
2014-2025
University of Southampton
2014-2025
University Hospital Southampton NHS Foundation Trust
2015-2025
University of Surrey
2024-2025
NIHR Southampton Biomedical Research Centre
2015-2022
University of Birmingham
2022
Seacroft Hospital
2022
Southampton City Council
2020
RELX Group (United States)
2020
International Society for Developmental Origins of Health and Disease
2015
To assess perinatal outcomes for pregnancies affected by suspected or confirmed SARS-CoV-2 infection.Prospective, web-based registry. Pregnant women were invited to participate if they had infection between 1st January 2020 and 31st March 2021 the impact of on maternal including miscarriage, stillbirth, fetal growth restriction, pre-term birth transmission infant.Between April 2021, study recruited 8239 participants who SARs-CoV-2 episodes in pregnancy 2021. Maternal death 14/8197 (0.2%)...
STUDY QUESTIONDo the amino acid levels of human uterine fluid vary with age, BMI, phase menstrual cycle, benign pathology or diet?
Abstract Purpose Observational studies have suggested negative associations between maternal 25-hydroxyvitamin D (25(OH)D) status and risk of hypertensive disorders pregnancy [pregnancy-induced hypertension (PIH) preeclampsia (PET)]. Data from intervention are limited. We hypothesised that vitamin supplementation would lower blood pressure (BP) during reduce the incidence pregnancy. Methods The Maternal Vitamin Osteoporosis Study (MAVIDOS) was a randomised placebo-controlled trial. Pregnant...
Offspring health outcomes are often linked with epigenetic alterations triggered by maternal nutrition and intrauterine environment. Strong experimental data also link paternal preconception pathophysiology in the offspring, but mechanism(s) routing effects of exposures remain elusive. Animal models have highlighted small non-coding RNAs (sncRNAs) as potential regulators effects. Here, we characterised baseline sncRNA landscape human sperm effect a 6-week dietary intervention on their...
Abstract STUDY QUESTION Does the type of incubator used to culture human preimplantation embryos affect development blastocyst stage and alter amino acid utilization in assisted reproduction? SUMMARY ANSWER Culturing a time lapse system (TLS) was associated with higher Day 5 formation rate altered when measured from 3 compared standard benchtop incubator. WHAT IS KNOWN ALREADY Culture environment is known be important for developing embryo. TLSs provide stable milieu allowing monitored situ,...
In vitro fertilisation (IVF) treatment provides an opportunity to study early developmental responses periconceptional dietary interventions. Retrospective studies have suggested links between preconception diet and fertility, more recently, a "Mediterranean" has been reported increase pregnancy rates by up 40%. addition, prospective examining increased intake of omega-3 polyunsaturated fats demonstrated quickened rate embryo development after IVF. However, now, few randomised controlled...
Abstract The fatty acid composition of human follicular fluid is important for oocyte development and pregnancy following in vitro fertilization (IVF). This study investigated whether a dietary intervention that included an increase marine omega‐3 acids, olive oil vitamin D alters the fluid. association lifestyle factors with was also investigated. Fifty‐five couples awaiting IVF were randomized to receive 6‐week treatment cooking, oil‐based spread, daily supplement drink enriched acids...
Abstract Offspring health outcomes are often linked with epigenetic alterations triggered by maternal nutrition and intrauterine environment. Strong experimental data also link paternal preconception pathophysiology in the offspring, but mechanism(s) routing effects of exposures remain elusive. Animal models have highlighted small non-coding RNAs (sncRNAs) as potential regulators effects, though less is known about existence similar mechanisms human sperm. Here, we first characterised...
Abstract Background Observational studies relating maternal 25-hydroxyvitamin D status to timing and mode of delivery have reported inconsistent results. We assessed the effect antenatal cholecalciferol supplementation on incidence preterm birth, post-partum haemorrhage (PPH). Methods MAVIDOS was a randomized, double-blind, placebo-controlled trial 1000 IU/day from 14 weeks’ gestation until delivery. Gestational age, [categorized as spontaneous vaginal (SVD), instrumental (including forceps...
Around the world, individuals are living longer, but an increased average lifespan does not always equate to healthspan. With advancing age, prevalence of ageing-related diseases can have a significant impact on health status, functional capacity, and quality life. It is therefore vital develop comprehensive classification staging systems for pathologies, syndromes. This will allow societies better identify, quantify, understand, meet healthcare, workforce, wellbeing, socioeconomic needs...
<h3>Background</h3> Asthma is the most common chronic disease in children. Maternal asthma/allergy are risk factors for developing childhood asthma suggesting a genetic and environmental contribution. The mechanisms of how maternal environment influences susceptibility to remain unclear. <h3>Aims</h3> To study effects MEP female patients with on associated mediators that may predispose early life. <h3>Methods</h3> 10 (AS n=81) 7 healthy controls (HC n=92) were randomly selected from our...