A5079645451- MicroRNA in disease regulation
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Multiple Myeloma Research and Treatments
- Cardiovascular Conditions and Treatments
- Mitochondrial Function and Pathology
- Cancer therapeutics and mechanisms
- Protein Degradation and Inhibitors
- Circular RNAs in diseases
- Bioinformatics and Genomic Networks
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Advanced Causal Inference Techniques
- Muscle Physiology and Disorders
- Statistical Methods and Bayesian Inference
- Neuroinflammation and Neurodegeneration Mechanisms
- Diet and metabolism studies
- Single-cell and spatial transcriptomics
- Statistical Methods and Inference
- Gene expression and cancer classification
- Parkinson's Disease Mechanisms and Treatments
- Nutrition, Genetics, and Disease
- Prenatal Screening and Diagnostics
- Neurogenetic and Muscular Disorders Research
Agency for Science, Technology and Research
2017-2025
Singapore Institute for Clinical Sciences
2017-2024
Bioinformatics Institute
2022-2024
University of Ioannina
2024
Imperial College London
2024
Star Technology and Research (United States)
2024
Nanjing Medical University
2022-2023
The causes of impaired skeletal muscle mass and strength during aging are well-studied in healthy populations. Less is known on pathological age-related wasting weakness termed sarcopenia, which directly impacts physical autonomy survival. Here, we compare genome-wide transcriptional changes sarcopenia versus age-matched controls biopsies from 119 older men Singapore, Hertfordshire UK Jamaica. Individuals with reproducibly demonstrate a prominent signature mitochondrial bioenergetic...
A drug discovery and optimization platform uncovered effective therapeutic combinations for bortezomib-resistant multiple myeloma.
Background Better predictors of amyotrophic lateral sclerosis disease course could enable smaller and more targeted clinical trials. Partially to address this aim, the Prize for Life foundation collected de-identified records from sufferers who participated in trials investigational drugs made them available researchers PRO-ACT database. Methods In study, time series data subjects were fitted exponential models. Binary classes decline total score functional rating scale revised (ALSFRS-R)...
Offspring health outcomes are often linked with epigenetic alterations triggered by maternal nutrition and intrauterine environment. Strong experimental data also link paternal preconception pathophysiology in the offspring, but mechanism(s) routing effects of exposures remain elusive. Animal models have highlighted small non-coding RNAs (sncRNAs) as potential regulators effects. Here, we characterised baseline sncRNA landscape human sperm effect a 6-week dietary intervention on their...
Epigenomes are tissue specific and thus the choice of surrogate can play a critical role in interpreting neonatal epigenome-wide association studies (EWAS) their extrapolation to target tissue. To develop better understanding link between specificity EWAS, contributions genotype prenatal factors, we compared genome-wide DNA methylation cord blood, two most accessible tissues at birth. In 295 neonates, was profiled using Infinium HumanMethylation450 beadchip arrays. Sites inter-individual...
Abstract Background Cohort studies increasingly collect biosamples for molecular profiling and are observing heterogeneity. High-throughput RNA sequencing is providing large datasets capable of reflecting disease mechanisms. Clustering approaches have produced a number tools to help dissect complex heterogeneous datasets, but selecting the appropriate method parameters perform exploratory clustering analysis transcriptomic data requires deep understanding machine learning extensive...
Mounting evidence indicate that long non-coding RNAs (lncRNAs) have critical roles in colorectal cancer (CRC) progression, providing many potential diagnostic biomarkers, prognostic and treatment targets. Here, we sought to investigate the role underlying regulatory mechanism of lncRNA small nucleolar RNA host gene 16 (<i>SNHG16</i>) CRC. The expressions <i>SNHG16</i> CRC were identified by RNA-sequencing quantitative reverse transcription PCR. functions explored a series <i>in vitro</i>...
Emerging evidence has suggested that circular RNAs (circRNAs) have vital functions during the initiation and progression of various diseases. However, circRNA potential mechanisms in colorectal cancer (CRC) are largely unknown. Here, we sought to investigate role underlying regulatory mechanism circ0104103 CRC. was validated by quantitative RT-PCR (qRT-PCR) Sanger sequencing. Gain- loss-of-function assays cell lines mouse xenograft models were utilized effects RNA pull-down assays,...
Abstract Several cardiovascular traits and diseases co-occur with Alzheimer’s disease. We mapped their shared genetic architecture using multi-trait genome-wide association studies. Subsequent fine-mapping colocalisation highlighted 16 loci associated both diseases. prioritised rs11786896, which colocalised disease, atrial fibrillation expression of PLEC in the heart left ventricle, rs7529220, C1Q family genes. Single-cell RNA-sequencing data, co-expression network protein-protein...
Statistical inference on neuroimaging data is often conducted using a mass-univariate model, equivalent to fitting linear model at every voxel with known set of covariates. Due the large number models, it challenging check if selection covariates appropriate and modify this adequately. The use standard diagnostics, such as residual plotting, clearly not practical for data. However, crucial regression ensure valid statistical inference. In particular, mean needs be reasonably well specified....
Abstract Offspring health outcomes are often linked with epigenetic alterations triggered by maternal nutrition and intrauterine environment. Strong experimental data also link paternal preconception pathophysiology in the offspring, but mechanism(s) routing effects of exposures remain elusive. Animal models have highlighted small non-coding RNAs (sncRNAs) as potential regulators effects, though less is known about existence similar mechanisms human sperm. Here, we first characterised...
Asians are underrepresented across many omics databases, thereby limiting the potential of precision medicine in nearly 60% global population. As such, there is a pressing need for multi-omics derived quantitative trait loci (QTLs) to fill knowledge gap complex traits populations Asian ancestry. Here, we provide first blood-based analysis pregnant women, constituting high-resolution genotyping (N = 1079), DNA methylation 915) and transcriptome profiling 238). Integrative identified 219 154...
<title>Abstract</title> Several cardiovascular (CV) traits and diseases co-occur with Alzheimer’s disease (AD). We mapped their shared genetic architecture using multi-trait genome-wide association studies. Subsequent fine-mapping colocalisation highlighted 19 loci associated both AD CV diseases. prioritised rs11786896, which colocalised AD, atrial fibrillation (AF) expression of <italic>PLEC</italic> in the heart left ventricle, rs7529220, AF <italic>C1Q</italic> family genes. Single-cell...
Abstract Thioredoxin reductase (TXNRD1) acts as part of a major enforcer redox homeostasis in the intracellular environment. However, its prognostic value and relationship between TXNRD1 core ferroptosis-related genes hepatocellular carcinoma remain unclear. Here, we systematically analyzed described potential function carcinoma. was aberrantly expressed several cancer types including liver cancer, elevated expression associated with tumor histological grade pathologic stage, resulting...