A5074985407- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Pregnancy and Medication Impact
- Reproductive System and Pregnancy
- Neonatal Respiratory Health Research
- Vitamin D Research Studies
- Maternal and fetal healthcare
- Connective tissue disorders research
- Gestational Diabetes Research and Management
- Gestational Trophoblastic Disease Studies
- Urological Disorders and Treatments
- Assisted Reproductive Technology and Twin Pregnancy
- Sunflower and Safflower Cultivation
- Erythrocyte Function and Pathophysiology
- Sphingolipid Metabolism and Signaling
- Histiocytic Disorders and Treatments
- Pregnancy-related medical research
Manchester Academic Health Science Centre
2016-2019
University of Manchester
2014-2019
St Mary's Hospital
2016-2019
St Mary's Hospital
2017-2018
Manchester University NHS Foundation Trust
2018
University of Southampton
2015
STUDY QUESTIONDo the amino acid levels of human uterine fluid vary with age, BMI, phase menstrual cycle, benign pathology or diet?
Extravillous trophoblast (EVT) cells are responsible for decidual stromal invasion, vascular transformation, and the recruitment functional modulation of maternal leukocytes in first-trimester pregnant uterus. An early disruption EVT function leads to placental insufficiency underlying pregnancy complications such as preeclampsia fetal growth restriction. Vasoactive intestinal peptide (VIP) is a vasodilating immune modulatory factor synthesized by cells. However, its role placenta has not...
Failure of trophoblast invasion and remodelling maternal blood vessels leads to the pregnancy complication pre-eclampsia (PE). In other systems, sphingolipid, sphingosine-1-phosphate (S1P), controls cell migration therefore this study determined its effect on extravillous (EVT) function. A transwell system was used assess behaviour three lines, Swan-71, SGHPL-4, JEG3, primary human trophoblasts in presence or absence S1P, S1P pathway inhibitors 1,25(OH)2D3. QPCR immunolocalisation were...
Fetal growth restriction (FGR) presents with an increased risk of stillbirth and childhood adulthood morbidity. Melatonin, a neurohormone antioxidant, has been suggested as having therapeutic benefit in FGR. We tested the hypothesis that melatonin would increase fetal two mouse models FGR which together represent spectrum placental phenotypes this complication: namely endothelial nitric oxide synthase knockout (eNOS-/-) abnormal uteroplacental blood flow, specific Igf2 (P0+/-) demonstrates...
The eNOS-/- mouse provides a well-characterized model of fetal growth restriction (FGR) with altered uterine and umbilical artery function reduced utero- feto-placental blood flow. Pomegranate juice (PJ), which is rich in antioxidants bioactive polyphenols, has been posited as beneficial dietary supplement to promote cardiovascular health. We hypothesized that maternal supplementation PJ will improve thereby enhance the FGR. Wild type (WT, C57Bl/6J) mice were supplemented from E12.5-18.5...
The ANP knockout mouse is reported to exhibit pregnancy-associated hypertension, proteinuria and impaired placental trophoblast invasion spiral artery remodeling, key features of pre-eclampsia (PE). We hypothesized that these mice may provide a relevant model human PE with associated fetal growth restriction (FGR). Here, we investigated pregnancies wild type (ANP+/+), heterozygous (ANP+/-) (ANP−/-) mice. Maternal blood pressure did not differ between genotypes (E12.5, E17.5), weight (E18.5)...