A5000375093- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Neonatal Respiratory Health Research
- Gestational Diabetes Research and Management
- Reproductive System and Pregnancy
- Genetic Syndromes and Imprinting
- Epigenetics and DNA Methylation
- Prenatal Screening and Diagnostics
- Maternal and fetal healthcare
- Pregnancy and Medication Impact
- Assisted Reproductive Technology and Twin Pregnancy
- Folate and B Vitamins Research
- Neonatal and fetal brain pathology
- Ion channel regulation and function
- Ion Transport and Channel Regulation
- Metabolism and Genetic Disorders
- Prenatal Substance Exposure Effects
- Nitric Oxide and Endothelin Effects
- Electrolyte and hormonal disorders
- Amino Acid Enzymes and Metabolism
- Erythrocyte Function and Pathophysiology
- Aldose Reductase and Taurine
- Renal and related cancers
- Gestational Trophoblastic Disease Studies
- Magnesium in Health and Disease
AnaBios (United States)
2023-2024
University of Manchester
2012-2021
Manchester Academic Health Science Centre
2012-2021
St Mary's Hospital
2012-2021
Manchester University NHS Foundation Trust
2013-2021
St Mary's Hospital
2006-2017
St. Mary's Hospital
1991-2017
National Health Service
2013-2016
University of Auckland
2013
Medical Research Council
2013
The mammalian fetus is unique in its dependence during gestation on the supply of maternal nutrients through placenta. Maternal and fetal demand for need to be fine tuned healthy growth development along genetic trajectory. An altered balance between can lead deviations from this trajectory with long-term consequences health. We have previously shown that a knockout lacking imprinted placental-specific Igf2 transcript (P0), placenta compromised early but normal until late gestation,...
The placenta has evolved in eutherian mammals primarily to provide nutrients for the developing fetus. genetic control of regulation supply and demand maternal is not understood. In this review we argue that imprinted genes have central roles controlling both fetal for, placental of, nutrients. Recent studies on Igf2 (insulin-like growth factor 2) knockout mouse models experimental support hypothesis. These show effects transport capacity consistent with a role IGF-II modulating Imprinting...
Restricted fetal growth is associated with postnatal mortality and morbidity may be directly related to alterations in the capacity of placenta supply nutrients. We proposed previously that imprinted genes can regulate nutrient by placenta. Here, we tested hypothesis insulin-like factor 2 gene ( Igf2 ) transcribed from placental-specific promoter (P0) regulates development diffusional permeability properties mouse Using mice which had been deleted (P0), measured transfer vivo three inert...
Background Maternal perception of reduced fetal movement (RFM) is associated with increased risk stillbirth and growth restriction (FGR). DFM thought to represent compensation conserve energy due insufficient oxygen nutrient transfer resulting from placental insufficiency. To date there have been no studies structure in cases DFM. Objective determine whether maternal movements abnormalities function. Design Placentas were collected women RFM after 28 weeks gestation if delivery occurred...
Background Maternal perception of reduced fetal movement (RFM) is associated with increased risk stillbirth and growth restriction (FGR). RFM thought to represent compensation conserve energy due insufficient oxygen nutrient transfer resulting from placental insufficiency. Objective To identify predictors poor perinatal outcome after maternal movements (RFM). Design Prospective cohort study. Methods 305 women presenting 28 weeks gestation were recruited. Demographic factors clinical history...
Preeclampsia and fetal growth restriction are responsible for the majority of maternal perinatal morbidity mortality associated with complicated pregnancies. Although their etiologies complex multifactorial, both increased uterine artery resistance. Sildenafil citrate is able to rescue dysfunction observed ex vivo in arteries women preeclampsia. The ability sildenafil increase vasodilation, thereby decreasing resistance and, hence, ameliorated preeclampsia restriction, was tested a mouse...
Fetal growth restriction (FGR) is the inability of a fetus to reach its genetically predetermined potential. In absence genetic anomaly or maternal undernutrition, FGR attributable "placental insufficiency": inappropriate maternal/fetal blood flow, reduced nutrient transport morphological abnormalities placenta (e.g., altered barrier thickness). It not known whether these diverse factors act singly, in combination, having additive effects that may lead greater severity. We suggest...
Objectives Previous work suggests an association between air pollution exposure and adverse pregnancy outcomes, even at relatively low concentrations. Our aim was to quantify the effect of having on preterm birth (PTB) fetal growth in a large UK cohort using novel estimation technique [spatio-temporal (S-T) model] alongside traditional nearest stationary monitor (NSTAT). Methods All available postcodes from Northwest England outcome dataset during 2004–2008 were geocoded (N=203 562...
Stillbirth is frequently the result of pathological processes involving placenta. Understanding significance specific lesions hindered by qualitative subjective evaluation. We hypothesised that quantitative assessment placental morphology would identify alterations between different causes stillbirth and phenotype be independent post-mortem effects differ live births stillbirths with same condition.Placental tissue was obtained from an established cause death, those unknown births. Image...
We have investigated the functional characteristics of term human placental villous explants kept in long-term (7–11 days) culture. Fragments tissue (∼5–10 mg wet wt) were cultured supplemented CMRL-1066 culture medium for up to 11 days. After first day culture, syncytiotrophoblast appeared vacuolated and eventually degenerated. However, a new developed by 4, being indistinguishable from that fresh placenta Release chorionic gonadotrophin increased activity lactate dehydrogenase decreased...
Evidence is emerging that the ability of placenta to supply nutrients developing fetus adapts according fetal demand. To examine this adaptation further, we tested hypothesis placental maternofetal transport calcium requirements. We used a mouse model growth restriction, placental-specific Igf2 knockout (P0) mouse, shown previously transiently adapt System-A amino acid transporter activity relative growth. Fetal and weights in P0 mice were reduced when compared with WT at both embryonic day...
Pregnancy complications such as preeclampsia and fetal growth restriction are sometimes thought to be caused by placental abnormalities associated with reduced oxygenation. Oxygen-enhanced MRI (R1 contrast) BOLD (R2 * have the potential noninvasively investigate this oxygen environment at a range of gestational ages.Scanning was carried out 1.5 T under maternal air breathing in single slice 14 healthy pregnant subjects ages 21-37 weeks. We report R1 changes using respiratory-triggered...
Preeclampsia (PE) and fetal growth restriction (FGR) contribute significantly to maternal morbidity mortality. Although the causes of PE FGR are not fully understood, both conditions known be associated with impaired uterine artery blood flow. Resveratrol, a polyphenol found in number plants, has been shown induce relaxation arteries vitro as well improve many pathological FGR. We hypothesized that treatment endothelial nitric oxide synthase knockout mice (eNOS⁻/⁻)...