A5101895728- Advanced Glycation End Products research
- Cardiovascular Disease and Adiposity
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Atherosclerosis and Cardiovascular Diseases
- Osteoarthritis Treatment and Mechanisms
- Cardiovascular Function and Risk Factors
- Telomeres, Telomerase, and Senescence
- Diabetes and associated disorders
- Pain Mechanisms and Treatments
- Cardiac Imaging and Diagnostics
- Parkinson's Disease Mechanisms and Treatments
- Skin Diseases and Diabetes
- Medical research and treatments
- Mesenchymal stem cell research
- Diabetes Management and Research
- Diet and metabolism studies
- Coronary Interventions and Diagnostics
- Nutrition and Health in Aging
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammatory mediators and NSAID effects
- Vasculitis and related conditions
- Sports Performance and Training
- Pain Management and Treatment
- Glycosylation and Glycoproteins Research
- Shoulder Injury and Treatment
Oslo University Hospital
2016-2022
University of Oslo
2017-2020
To explore whether having long-term type 1 diabetes (>45 years) is associated with a higher prevalence of radiographic hand OA, erosive OA and increased pain, disability stiffness.In total N = 96 persons diagnosed before 1970 were included (mean [SD] age: 62.2 [7.4], mean HbA1c: 7.43 [0.80] 49 [51%] men). Regular measurements their HbA1c obtained till 2015. We 69 healthy controls without any 63.0 [7.0], 5.41 [0.32], 29 [42%] The groups compared for (Kellgren-Lawrence grade ≥2 in ≥1 joint)...
The aim was to assess coronary atherosclerosis, plaque morphology and associations cardiovascular risk factors epicardial adipose tissue (EAT) in patients with long duration of type 1 diabetes mellitus (T1DM).Eighty-eight ≥ 45 year T1DM 60 controls underwent CT angiography (CCTA) for evaluation artery volume (total, calcified or mixed/soft), calcification score (CAC) EAT.Plaques were detected 75 (85%) 28 (47%) controls, p < 0.01. Median (interquartile range) (mm3) vs. was: 21.0 (1.0-66.0)...
Elderly muscle seems less sensitive to the anabolic stimulus of a meal. Changes in blood concentrations leucine are suggested as one important trigger response muscle. The aim this study was investigate whether native whey protein, containing high amounts leucine, may be more potent stimulator protein synthesis (MPS) elderly than regular (WPC-80) or milk.
The shortening of leukocyte telomere length with age has been associated coronary disease, whereas the association type 1 diabetes is unclear. We aimed to explore lengths in patients regard artery compared healthy controls. longevity factors sirtuin and growth-differentiating factor 11 were investigated accordingly.
Background Neutrophil extracellular traps NETs have been linked to glucose and the pathogenesis of type 1 diabetes mellitus (T1DM). also play a role in vascular inflammation development coronary artery disease (CAD). The CAD progression patients with long-term T1DM is unclear. We aimed 1) investigate whether levels circulating markers were elevated subjects compared controls, 2) explore related presence CAD. Material Methods 102 &gt; 45 years 75 age-matched controls enrolled...
Type 1 diabetes is a risk factor for coronary heart disease. The underlying mechanism behind the accelerated atherosclerosis formation not fully understood but may be related to of oxidation products and advanced glycation end-products (AGEs). We aimed examine associations between collagen product methionine sulfoxide; AGEs methylglyoxal hydroimidazolone (MG-H1), glucosepane, pentosidine, glucuronidine/LW-1; serum receptors AGE (RAGE) with measures artery disease in patients long-term type...
Abstract Aims To compare reported level of bodily pain, overall and health‐related quality life (QoL), depression fatigue in people with long‐term type 1 diabetes vs. a comparison group without diabetes. Further, to examine the associations total pain QoL, depression, glycaemic control group. Methods Cross‐sectional study 104 (76% eligible) ≥ 45 years’ duration attending Norwegian Diabetes Centre 75 persons who completed questionnaires measuring (RAND‐36 domain), shoulder (Shoulder Pain...
To examine associations of metabolic parameters (mean 30 years' time-weighted HbA1c and low-density lipoprotein-cholesterol [LDL-c], current methionine sulfoxide [MetSO], advanced glycation end products [AGEs], inflammatory markers hypoglycaemia) with pain, fatigue, depression quality life (QoL) in people long-term type 1 diabetes.A total 104 persons diabetes ≥45 years duration were included. Participants completed questionnaires measuring bodily pain (RAND-36 domain lower scores indicate...
Around the world, individuals are living longer, but an increased average lifespan does not always equate to healthspan. With advancing age, prevalence of ageing-related diseases can have a significant impact on health status, functional capacity, and quality life. It is therefore vital develop comprehensive classification staging systems for pathologies, syndromes. This will allow societies better identify, quantify, understand, meet healthcare, workforce, wellbeing, socioeconomic needs...
Methylglyoxal (MGO), a reactive aldehyde forming advanced glycation end products (AGEs), is increased in diabetes and recognized by the immune system, resulting anti-AGE-specific autoantibodies. The association of these responses with macro- microvascular complications type 1 remains unclarified. We investigated associations between MGO-modified apolipoprotein B100 (apoB100) apoB100 peptide 5 (MGO-p5) autoantibodies coronary atherosclerosis retinopathy diabetes.IgM IgG against MGO-apoB100...
Objectives: Methylglyoxal (MGO), a reactive aldehyde forming advanced glycation end products (AGEs), is increased in diabetes and recognized by the immune system, resulting anti-AGE-specific autoantibodies. The association of these responses with macro-and microvascular complications type 1 remains unclarified. We investigated associations between MGO-modified ApoB100 peptide (MGO-p5) autoantibodies coronary atherosclerosis retinopathy diabetes. <p>Research Design Methods: IgM IgG...
Objectives: Methylglyoxal (MGO), a reactive aldehyde forming advanced glycation end products (AGEs), is increased in diabetes and recognized by the immune system, resulting anti-AGE-specific autoantibodies. The association of these responses with macro-and microvascular complications type 1 remains unclarified. We investigated associations between MGO-modified ApoB100 peptide (MGO-p5) autoantibodies coronary atherosclerosis retinopathy diabetes. <p>Research Design Methods: IgM IgG...