A5085239190- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Management of metastatic bone disease
- Musculoskeletal synovial abnormalities and treatments
- Cancer Diagnosis and Treatment
- Orthopaedic implants and arthroplasty
- Bone fractures and treatments
- Orthopedic Infections and Treatments
- Bone health and treatments
- COVID-19 and healthcare impacts
- Oral and Maxillofacial Pathology
- Hip and Femur Fractures
- Hip disorders and treatments
- Total Knee Arthroplasty Outcomes
- Pelvic and Acetabular Injuries
- Shoulder Injury and Treatment
- Cancer-related molecular mechanisms research
- Trauma and Emergency Care Studies
- Infective Endocarditis Diagnosis and Management
- Reconstructive Surgery and Microvascular Techniques
- Bone and Joint Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Bacterial Identification and Susceptibility Testing
- Elbow and Forearm Trauma Treatment
- Soft tissue tumors and treatment
Robert Jones and Agnes Hunt Orthopaedic Hospital
2016-2025
Keele University
2020-2025
Orthopaedic Research
2024
University of Birmingham
2020-2022
University of Dundee
2022
Ninewells Hospital
2022
NHS Tayside
2022
Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust
2005-2022
Institut de Virologie
2020-2021
Oxford University Hospitals NHS Trust
2021
Osteoblastoma and osteoid osteoma together are the most frequent benign bone-forming tumor, arbitrarily separated by size. In some instances, it can be difficult to differentiate osteoblastoma from osteosarcoma. Following our recent description of FOS gene rearrangement in these tumors, aim this study is evaluate value immunohistochemistry osteoma, osteoblastoma, osteosarcoma for diagnostic purposes. A total 337 cases were tested with antibodies against c-FOS: 84 osteoblastomas, 33 osteomas,...
Pigmented villonodular synovitis (PVNS) is a rare benign disease of the synovium joints and tendon sheaths, which may be locally aggressive. We present 18 patients with diffuse-type PVNS foot ankle followed for mean 5.1 years (2 to 11.8). There were seven men 11 women, age 42 (18 73). A total 13 underwent open or arthroscopic synovectomy, without post-operative radiotherapy. One had surgery at referring unit before presentation residual tibiotalar PVNS. The four who managed non-operatively...
Patients who have limb amputation for musculoskeletal tumours are a rare group of cancer survivors. This was prospective cross-sectional survey patients from five specialist centres sarcoma surgery in England. Physical function, pain and quality life (QOL) outcomes were collected after lower extremity bone or soft-tissue to evaluate the survivorship experience inform service provision. Of 250 patients, 105 (42%) responded between September 2012 June 2013. From these, completed questionnaires...
The role of machine learning (ML) in orthopaedics is expanding, with potential applications analysing patient data and making predictive assessments. This project utilised NHS PROMs from primary hip knee replacements to identify key trends assess whether this can reliably predict recovery rates based on patient-reported outcomes comorbidities. study used the England national dataset for 2018/2019 financial year, comprising 37,725 replacement entries 43,639 entries, each containing 139...
This study examines the presentation, management and outcomes of a series 10 patients with giant lipomatous tumours (defined as greater than 5 cm diameter) hand forearm who presented to our orthopaedic oncology service. All underwent local staging were discussed at multidisciplinary tumour meeting prior definitive surgery. In all cases, neurovascular structures required mobilization in order excise tumour. Seven benign lipomas one was neural fibrolipoma. The other two well differentiated...
The aim of this study was to validate the Mirels score in predicting pathological fractures metastatic disease lower limb.A total 62 patients with confirmed met inclusion criteria. Of patients, 32 were female and 30 male. mean age 65 years (35 89). primary malignancy originated from breast 27 (44%) prostate 15 (24%) kidney seven (11%), lung four (6%) patients. One patient (2%) had carcinoma lacrimal gland, two (3%) multiple myeloma, one lymphoma bone, five (8%) unknown primary. Plain...
Limb salvage is now customary in the treatment of primary bone tumours. The proximal tibia a frequent site for these neoplasms but reconstruction, especially children, formidable challenge. We reviewed 20 children with extendible replacements tibia, all minimum follow-up five years. Five died from their disease and, remaining 15, four had above-knee amputations complications. Infection occurred seven patients; it was related to lengthening procedure. Aseptic loosening inevitable younger and...
Angiomatoid fibrous histiocytoma is a neoplasm of uncertain histogenesis, which most commonly arises in the subcutaneous tissue extremities children and young adults. We report first case calcifying sclerosing variant this entity. This arose bone—a site where there has been just 1 previously published typical (nonsclerosing/mineralizing) angiomatoid histiocytoma. The patient presented with classical paraneoplastic syndrome that can occur tumor type and, apart from described extracellular...
Osteoid osteoma and osteoblastoma have, in the past, been variously regarded as both similar distinct entities. Currently, WHO classifies these tumours separately. We compared archetypal cases to identify novel histomorphological immunohistochemical features attempting clarify their mutual relationship.10 osteoid osteomas 20 osteoblastomas (10 spinal 10 non-spinal) were retrieved reviewed clinically, radiologically histologically. Immunohistochemistry was performed for: desmin, SMA,...
We report our results in 24 children with malignant primary bone tumours of the distal femur treated a Stanmore extendible endoprosthesis (SEER). This consists femoral component that can be lengthened, constrained knee and an uncemented sliding tibial which crosses proximal physeal plate perpendicularly. The average age patients at diagnosis was ten years mean follow-up 4.7 (2.5 to 7.9). growth affected tibia 76% (18 136) fibula 83% (15 750) unaffected limb. Measurement arrest lines showed...
The purpose of this study was to determine if clinical and radiological surveillance cartilage tumours with low biological activity is appropriate.A total 98 patients an intramedullary neoplasm in a long bone met our inclusion criteria were included the study. These had undergone 384 scans. Patients follow-up more than three years (46 patients) divided into two groups: active group (11 latent (35 patients).Active lesions growth all planes that > 6 mm, whilst < mm growth. Most heavily...
Central conventional chondrosarcoma (CS) is the most common subtype of primary malignant bone tumour in adults. Treatment options are usually limited to surgery, and prognosis challenging. These tumours characterised by presence absence IDH1 IDH2 mutations, recently, TERT promoter alterations have been reported around 20% cases. The effect these mutations on clinical outcome remains unclear. purpose this study was determine if prognostic accuracy can be improved addition genomic data,...
Background and Objectives The Toronto extremity salvage score (TESS) assesses physical function following limb for bone soft tissue sarcoma. In 2012, Clayer et al. showed increasing age affects the TESS in normal individuals. purpose of this study was to investigate what other patient factors affect outcome? Methods We reviewed scores, age, sex, BMI, diagnosis, smoking status, social deprivation patients who have undergone our unit. Data were extracted from tumor database reviewed....
Purpose. We report on the quality of life following treatment for a malignant primary bone tumour around knee in skeletally immature children.Patients. Patients (n = 41; mean age 18 years; range 8-28) had all experienced chemotherapy neo-adjuvant setting, surgical excision and endoprosthetic replacement.Methods. Interviews were conducted separately with child mother focused mobility, body image impact schooling, employment plans future.Results. Mobility group was variable. Only 12% reported...