A5032146877- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Anorectal Disease Treatments and Outcomes
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Enhanced Recovery After Surgery
- Cardiac, Anesthesia and Surgical Outcomes
- Surgical Simulation and Training
- Genetic factors in colorectal cancer
- Pelvic and Acetabular Injuries
- Diverticular Disease and Complications
- Hernia repair and management
- COVID-19 and healthcare impacts
- Abdominal Surgery and Complications
- Global Health and Surgery
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Delphi Technique in Research
- Anatomy and Medical Technology
- Cancer survivorship and care
- Pelvic floor disorders treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Appendicitis Diagnosis and Management
- Simulation-Based Education in Healthcare
Leeds Teaching Hospitals NHS Trust
2019-2025
Association of Surgeons of Great Britain and Ireland
2025
University of Leeds
2018-2024
St James's University Hospital
2019-2024
Karunya University
2021
St. Vincent's University Hospital
2019
Ninewells Hospital
2008-2018
University of Dundee
2008-2018
Royal Prince Alfred Hospital
2016
Queen Margaret Hospital
2011-2012
Introduction As a result of improving survival rates, the adverse consequences rectal cancer surgery are becoming increasingly recognised. Low anterior resection syndrome (LARS) is one such consequence and describes constellation bowel symptoms after which includes urgency, faecal incontinence, stool clustering incomplete evacuation. LARS has significant impact on quality life (QoL) present in up to 75% patients first year surgery. Despite this, little known about natural history there poor...
BackgroundPelvic exenteration for locally advanced rectal cancer (LARC) and recurrent (LRRC) is technically challenging but increasingly performed in specialist centres. The aim of this study was to compare outcomes over time.
Pelvic exenteration surgery is an umbrella term for a multitude of operative techniques locally advanced and recurrent pelvic malignancy. Currently, there heterogeneity in the description that limits interpretation patient outcome collaboration between units through standardized data collection. Our study aims to develop consensus lexicon describe components extended surgery.This adopted mixed-methods approach using semi-structured interviews, questionnaires, focus groups validation...
BACKGROUND: Locally advanced pelvic malignancy can be associated with disabling symptoms and reduced quality of life. If resectable clear margins, a exenteration offer long-term survival improved Its role in the palliation has been described; however, clinical outcomes surgical indication are poorly defined. OBJECTIVE: This study describes quality-of-life after palliative for malignancy. DESIGN: Clinical data patient-reported were collected patients undergoing symptom palliation. SETTINGS:...
Empty pelvis syndrome (EPS) is a significant source of morbidity following pelvic exenteration (PE), but undefined. EPS outcome reporting and descriptors radicality PE are inconsistent; therefore, the best approaches for prevention unknown. To facilitate future research into EPS, aim this study to define measurable core set, descriptor set written definition EPS. Consensus on strategies mitigate was also explored.
To establish globally applicable benchmark outcomes for pelvic exenteration (PE) in patients with locally advanced primary (LARC) and recurrent rectal cancer (LRRC), using achieved at highly specialised centres.
Summary Visualizing overall tissue architecture in three dimensions is fundamental for validating and integrating biochemical, cell biological visual data from less complex systems such as cultured cells. Here, we describe a method to generate high‐resolution three‐dimensional image of intact mouse gut tissue. Regions highest interest lie between 50 200 μm within this The quality usefulness with depth limited owing problems associated scattered light, photobleaching spherical aberration....
Background The National Institute for Health and Care Excellence (NICE) published NG12 in 2015. referral criteria suspected colorectal cancer (CRC) caused controversy, because tests occult blood faeces were recommended. Faecal immunochemical haemoglobin (FIT), which estimate faecal concentrations (f-Hb), might more than fulfil the intentions. Our aim was to compare utility of f-Hb as initial investigation with NICE symptom-based guidelines. Methods Data from three studies included. Patients...
Objective Age, sex, and deprivation are known factors influencing colorectal (bowel) cancer screening uptake. We investigated the influence of these on uptake over time. Methods Data from Scottish Bowel Screening Programme (SBoSP) were collected between 2007 2014. End-points for analysis uptake, faecal occult blood test positivity, disease detection, adjusted age, deprivation, year screening. Results From 5,308,336 individual episodes documented, gradually increased with increasing age up to...
Abstract Background The growth pattern of colorectal cancer is seldom investigated. This cohort study aimed to explore tumour rate in cancers managed non-surgically or deemed not resectable, and determine its implication for prognosis. Methods Consecutive patients with colonic rectal adenocarcinoma were identified through the multidisciplinary team database at Leeds Teaching Hospitals NHS Trust over a 2-year interval. Patients who received no treatment (surgery, stenting, defunctioning...
Colorectal cancer patients identified with indeterminate pulmonary nodules (IPN) in the absence of other metastasis represent a clinical dilemma. This study aimed to identify characteristics that could predict which truly represented an attempt optimize therapy and reduce number follow-up chest CT scans performed.All colon or rectal who presented between 2004 2008 were analysed. Patients IPN on staging from dedicated prospective database medical records analysed follow up recorded. obvious...
Abstract Aim The delivery of the Scottish Bowel Screening Programme ( SB o SP ) is rooted in provision a high quality, effective and participant‐centred service. Safe colonoscopy forms an integral part process. Additional accreditation as multi‐faceted programme for participating colonoscopists, England, does not exist Scotland. This study aimed to describe quality compare this English national screening standards. Methods Data were collected from between 2007 2014. End‐points analysis...
The international FOxTROT trial, recently published in the Journal of Clinical Oncology is first randomized controlled trial testing neoadjuvant chemotherapy (NAC) with oxaliplatin and 5-fluorouracil locally advanced, but operable, colon cancer. met its primary endpoint fewer patients experiencing recurrent or residual disease at 2 years NAC compared control (16.8% vs. 21.2%, risk ratio = 0.74, p 0.042). Translating findings into improved patient outcomes dependent on implementation new...