A5074845684- Pulmonary Hypertension Research and Treatments
- Colorectal Cancer Surgical Treatments
- Appendicitis Diagnosis and Management
- Diverticular Disease and Complications
- Cardiovascular Issues in Pregnancy
- Heart Failure Treatment and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Bladder and Urothelial Cancer Treatments
- Anorectal Disease Treatments and Outcomes
- Urological Disorders and Treatments
- Vascular Anomalies and Treatments
- Thyroid and Parathyroid Surgery
- Abdominal Surgery and Complications
- Thyroid Cancer Diagnosis and Treatment
- Global Health and Surgery
- Pelvic and Acetabular Injuries
- Enhanced Recovery After Surgery
- Urinary and Genital Oncology Studies
- Cancer survivorship and care
- Pneumocystis jirovecii pneumonia detection and treatment
- Healthcare cost, quality, practices
- Ethics and Legal Issues in Pediatric Healthcare
- Human-Automation Interaction and Safety
- Occupational Health and Safety Research
- Pharmaceutical studies and practices
University of Leeds
2017-2025
Garvan Institute of Medical Research
2024
United Therapeutics (United States)
2018-2021
Triangle
2019-2021
MRC Clinical Trials Unit at UCL
2020
PURPOSE High-grade nonmuscle invasive bladder cancer (HRNMIBC) is a heterogeneous disease. Treatments include intravesical maintenance Bacillus Calmette-Guerin (mBCG) and radical cystectomy (RC). We wanted to understand whether randomized trial comparing these options was possible. MATERIALS AND METHODS conducted two-arm, prospective multicenter study determine the feasibility in Calmette-Guerin-naive patients. Participants had new high-risk HRNMIBC suitable for both treatments. Random...
Introduction As a result of improving survival rates, the adverse consequences rectal cancer surgery are becoming increasingly recognised. Low anterior resection syndrome (LARS) is one such consequence and describes constellation bowel symptoms after which includes urgency, faecal incontinence, stool clustering incomplete evacuation. LARS has significant impact on quality life (QoL) present in up to 75% patients first year surgery. Despite this, little known about natural history there poor...
Introduction Postsurgical hypoparathyroidism (PoSH) is an iatrogenic condition that occurs as a complication of several different procedures with thyroid surgery being the most common. PoSH has significant short- and long-term morbidities. The volume increasing, therefore likely to increase. Some studies have shown promising results using near-infrared fluorescence (NIRF) imaging in reducing risk which potential significantly reduce morbidity costs associated monitoring treatment. Methods...
Introduction High-risk non-muscle invasive bladder cancer (HRNMIBC) is a heterogeneous disease that can be difficult to predict. While around 25% of cancers progress invasion and metastases, the remaining majority tumours remain within bladder. It uncertain whether patients with HRNMIBC are better treated intravesical maintenance BCG (mBCG) immunotherapy or primary radical cystectomy (RC). A definitive randomised controlled trial (RCT) needed compare these two different treatments but may...
Approximately 30 000 people undergo major emergency abdominal gastrointestinal surgery annually, and 36 per cent of these procedures (around 10 800) are carried out for colorectal pathology. Some 14 all patients requiring have a laparoscopic procedure. The aims the LaCeS (laparoscopic versus open in acute setting) feasibility trial were to assess feasibility, safety acceptability performing large-scale definitive phase III RCT, with comparison pathology.LaCeS was designed as prospective,...
Adverse event (AE) reporting is essential in clinical trials. Clinician interpretation can result under-reporting; therefore, the value of patient self-reporting has been recognized. The National Cancer Institute developed a Patient-Reported Outcomes version Common Terminology Criteria for Events (PRO-CTCAE) direct AE reporting. A nonrandomized prospective cohort feasibility study aimed to explore compliance and acceptability an electronic (Internet or telephone) system collecting...
Given the improved convenience of oral prostacyclins, there is a shift toward their use in treating pulmonary arterial hypertension (PAH).
Benefits of laparoscopic surgery are well recognised but uptake in rural settings low- and middle-income countries is limited due to implementation barriers. Gasless laparoscopy has been proposed as an alternative requires a trained surgical workforce upscale. This study evaluates feasibility implementing structured training programme for surgeons North-East India.A 3-day was held at Kolkata Medical College March 2019. Laparoscopic knowledge Fundamentals Skills (FLS) were assessed pre post...
The 2015 European Society of Cardiology/European Respiratory treatment guidelines recommend frequent risk assessment in pulmonary arterial hypertension utilizing variables. Our objectives were: (1) to investigate the impact inhaled treprostinil on stratification using French noninvasive approach and REVEAL 2.0, (2) analyze prognostic utility both methods predominantly New York Heart Association/World Health Organization functional class III/IV cohorts TRIUMPH BEAT. A post hoc analysis was...
Introduction Acute colorectal surgery forms a significant proportion of emergency admissions within the National Health Service. There is limited evidence to suggest minimally invasive may be associated with improved clinical outcomes in this cohort patients. Consequently, there need assess effectiveness and cost-effectiveness laparoscopic acute setting. However,emergency surgical trials have previously been difficult conduct due issues surrounding recruitment equipoise. The LaCeS...
Abstract Introduction As a result of improving survival rates, the adverse consequences rectal cancer surgery are becoming increasingly recognised. Low Anterior Resection Syndrome (LARS) is one such consequence and describes constellation bowel symptoms after which includes urgency, faecal incontinence, stool clustering incomplete evacuation. LARS has significant impact on Quality-of-Life (QoL) present in up to 75% patients first year surgery. Despite this, little known about natural history...
Abstract Pancreatic cancer (PC) is highly lethal, with a five-year survival rate of ∼13%. PC characterised by progressive cancer-associated fibrosis. We and others have shown that targeting fibrosis can improve chemotherapy efficacy impair metastasis in pre-clinical models. As such, we aimed to use integrated temporal proteomics dissect the matrix signatures pancreatic tumours from highly-metastatic KPC (Pdx1-Cre; LSL-K-rasG12D/+; LSL-p53R172H/+) poorly-metastatic KPflC LSL-p53fl/+) mouse...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with 5-year survival rate of only 12%. More than 80% PDAC patients cannot undergo potentially curative surgical resection due to the presentation advanced, metastatic disease, and are instead offered systemic chemotherapy regimens which resistance rapidly acquired. FOLFIRINOX offers an 11.1-month median compared 6.8 months Gemcitabine. Rapid onset FOLFIRINOX, coupled lack alternative targeted therapies, ultimately...
AbstractThe authors describe their Ethics Program's transition from utilizing ethics committees to instead implementing a three-initiative structure consisting of Grand Rounds, an Liaison Network, and Advisory Group. They first outline the history committees. Then, they discuss Program challenges that posed. Next, approach developing new initiatives for non-ethicist healthcare professionals engage in work what these specifically entail. then how worked secure buy-in dissolving and, based on...
Abstract Background Undertaking randomized clinical trials (RCTs) in emergency surgical settings is associated with methodological and practical challenges. This study explored patients’ clinicians’ perspectives the conduct of an RCT comparing laparoscopic open colorectal surgery acute setting. Methods All eligible patients screened enrolled for ‘Laparoscopic versus setting (LaCeS)’ multicentre, feasibility trial five UK NHS Trusts were invited to respond a survey. Patients healthcare...
Oral treprostinil has recently been shown to delay disease progression in patients with pulmonary arterial hypertension a long‐term outcomes study. The potential advantages of an oral formulation have resulted transitioning from inhaled treprostinil. current study reports retrospective analysis who transitioned treatment A multicenter chart review was conducted for 29 that Data were collected initiation and followed until discontinuation or the end observation period. Persistence calculated...
Oral treprostinil may be an option for low‐ and intermediate‐risk patients with pulmonary arterial hypertension, a rare lung vascular disease. This open‐label extension study collected data on participants who completed previously reported, placebo‐controlled oral studies. Eligible had the prospective parent studies took increasing doses of twice daily; some later transitioned to three times daily dosing. Investigators measured 6‐minute walk distance at Month 12 as sole efficacy measure but...