A5084715821- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Diverticular Disease and Complications
- Gastrointestinal disorders and treatments
- Pancreatic and Hepatic Oncology Research
- Insurance, Mortality, Demography, Risk Management
- Radiomics and Machine Learning in Medical Imaging
- Neutropenia and Cancer Infections
- Reproductive Health and Contraception
- Family Dynamics and Relationships
- Canadian Identity and History
- Mycobacterium research and diagnosis
- Colorectal Cancer Surgical Treatments
- Homicide, Infanticide, and Child Abuse
- Nutrition and Health in Aging
- Hemoglobinopathies and Related Disorders
- Genetics, Bioinformatics, and Biomedical Research
- Inflammatory Biomarkers in Disease Prognosis
- Inflammatory Bowel Disease
- Gender, Labor, and Family Dynamics
- Iron Metabolism and Disorders
- Genetic factors in colorectal cancer
- Assisted Reproductive Technology and Twin Pregnancy
- Gastrointestinal Bleeding Diagnosis and Treatment
- Colorectal and Anal Carcinomas
Ninewells Hospital
2015-2025
NHS Tayside
2001-2025
University of Dundee
2001-2022
Scottish National Blood Transfusion Service
2021
Molecular Medicine Ireland
2017
King's Cross Hospital
2013-2015
Townsville Hospital
1994
<h3>Objective</h3> In primary care, assessing which patients with bowel symptoms harbour significant disease (cancer, higher-risk adenoma or IBD) is difficult. We studied the diagnostic accuracies of faecal haemoglobin (FHb) and calprotectin (FC) in a cohort symptomatic patients. <h3>Design</h3> From October 2013 to March 2014, general practitioners were prompted request FHb FC when referring secondary care. Faecal samples analysed for (EIKEN OC-Sensor io) (BÜHLMANN Calprotectin ELISA)....
Objective To determine whether a faecal immunochemical test (FIT) for haemoglobin concentration (f-Hb) can be safely implemented in primary care as rule-out significant bowel disease (SBD) (colorectal cancer (CRC), higher risk adenoma (HRA) and inflammatory (IBD)) when used an adjunct to the clinical assessment of new symptoms. Design Single-centre prospective cohort study all patients who attended submitted FIT first calendar year service beginning December 2015. f-Hb was estimated using...
Background In primary care, National Institute for Health and Care Excellence suspected cancer guidelines recommend measuring faecal haemoglobin (f-Hb) if colorectal (CRC) is suspected, with a referral threshold of ≥10 µg Hb/g faeces defining 3% risk, but most have normal colonoscopy. Objective Examine whether combining f-Hb, patient age iron-deficient anaemia (IDA) status improves risk prediction. Design Retrospective single-centre observational study symptomatic patients who submitted...
Faecal immunochemical tests (FIT) are becoming widely used in colorectal cancer screening. Estimation of faecal haemoglobin concentration a large group prompted an observational study on gender and age.A single estimate was made using quantitative automated immunoturbidimetry. Potential reference intervals were calculated for men women age quintiles according to the Clinical Laboratory Standards Institute Approved Guideline. The percentages positive results at number concentrations....
Aims Guaiac faecal occult blood tests are being replaced by immunochemical (FIT). We investigated whether haemoglobin concentration (f-Hb) was related to stage in progression of colorectal neoplasia, studying cancer and adenoma characteristics an evaluation quantitative FIT as a first-line screening test. Methods invited 66 225 individuals aged 50–74 years provide one sample faeces. f-Hb measured on samples from 38 720 responders. Colonoscopy findings pathology data were collected the 943...
Because of their many advantages, faecal immunochemical tests (FIT) are superseding traditional guaiac-based occult blood in bowel screening programmes.A quantitative FIT was adopted for use two evaluation National Health Service (NHS) Boards Scotland using a cut-off haemoglobin concentration chosen to give positivity rate equivalent that achieved the Scottish Bowel Screening Programme. Uptake and clinical outcomes were compared with results obtained contemporaneously other similar NHS...
The study aimed to determine whether faecal haemoglobin (Hb) concentration can assist in deciding who with lower abdominal symptoms will benefit from endoscopy.Faecal Hb concentrations were measured on single samples 280 patients referred for gastrointestinal tract endoscopy primary care NHS Tayside completed a immunochemical test (FIT) and underwent subsequent endoscopy.Among 739 invited patients, FIT by (median age 63 (18-84) years; 59.6% women), median time between of 9 days. Six (2.1%)...
Prediction models for colorectal cancer (CRC) detection in symptomatic patients, based on easily obtainable variables such as fecal haemoglobin concentration (f-Hb), age and sex, may simplify CRC diagnosis. We developed, then externally validated, a multivariable prediction model, the FAST Score, with data from five diagnostic test accuracy studies that evaluated quantitative immunochemical tests patients referred colonoscopy. The of Score derivation validation cohorts was compared...
To investigate the characteristics of participants screened for bowel cancer using a faecal immunochemical test haemoglobin (FIT).Scottish Bowel Screening Programme.65909 men and women in two NHS Boards, aged 50 to 74, were invited participate an evaluation FIT as first-line test. Uptake was calculated by sex, age quintiles, deprivation compared with group who had completed guaiac occult blood (gFOBT) whom details well documented.FIT kits from 38672 tested. The overall uptake 58.7%...
Objective Faecal immunochemical tests (FIT) are replacing guaiac faecal occult blood (FOBT) in colorectal cancer (CRC) screening. Data from the first year of FIT screening were compared with those FOBT and assumptions based on a pilot evaluation FIT. Design uptake, positivity, positive predictive value (PPV) for CRC higher-risk adenoma participants FIT-based Scottish Bowel Screening Programme (n=919 665), threshold 80 µg Hb/g faeces, penultimate FOBT-based programme (n=862 165) (n=66 225)....
Abstract Aim Lower gastrointestinal (GI) symptoms are poor predictors of colorectal cancer (CRC). The aim this study was to examine the diagnostic yield colonoscopy by faecal haemoglobin (f‐Hb) concentration in symptomatic patients assessed primary care immunochemical testing (FIT). Method In three Scottish NHS Boards, FIT kits (HM‐JACKarc, Hitachi Chemical Diagnostics Systems Co., Ltd, Tokyo, Japan) were used general practitioners guide referrals for with lower GI (laboratory data studied...
Abstract Background Quantitative faecal immunochemical test (qFIT) to detect stool haemoglobin is used for colorectal cancer screening at a population level in UK (& Europe) with high patient acceptability due its ease of use and relative low cost . We evaluate the clinical utility qFIT calprotectin (fCal) IBD. Methods UC CD patients from prospective, multi-centre longitudinal MUSIC study (2020-2024; www.musicstudy.uk) were included. fCal samples collected every three months five time...
Abstract Aim Faecal immunochemical testing (FIT) is used in the detection of colorectal cancer (CRC). FIT invariably at a single faecal haemoglobin (f‐Hb) concentration threshold. The aim this observational study was to explore risk scoring models (RSMs) with f‐Hb and other factors for CRC symptomatic patients attending primary care, potentially speeding diagnosis saving endoscopy resources. Method Records completing were linked Scottish Cancer Registry databases symptoms, full blood count...
Objectives To evaluate a two-tier reflex guaiac-based faecal occult blood test (gFOBT)/faecal immunochemical (FIT) algorithm in screening for colorectal cancer. Setting Fourth round NHS Tayside (Scotland). Methods gFOBT were sent to 50–74-year-olds. Participants with five or six windows positive offered colonoscopy. one four FIT and, if positive, providing an untestable Outcomes following results, cancer stages and key performance indicators assessed. Results Of 131,885 invited, 73,315...
Objective To investigate the relationship between deprivation and faecal haemoglobin concentration (f-Hb). Setting Scottish Bowel Screening Programme. Methods A total of 66725 men women, aged 50 to 74, were invited provide a single sample for immunochemical test. Deprivation was estimated using Index Multiple quintiles: f-Hb measured (OC-Sensor, Eiken, Japan) on 38439 participants. The quintiles examined. Results Median age 60 years, 53.6% with 14.1%, 19.7%, 17.7%, 25.9% 22.6% in lowest...
Background The National Institute for Health and Care Excellence (NICE) published NG12 in 2015. referral criteria suspected colorectal cancer (CRC) caused controversy, because tests occult blood faeces were recommended. Faecal immunochemical haemoglobin (FIT), which estimate faecal concentrations (f-Hb), might more than fulfil the intentions. Our aim was to compare utility of f-Hb as initial investigation with NICE symptom-based guidelines. Methods Data from three studies included. Patients...
A controlled, double-blind study was performed to compare the prior administration of intravenous saline 4 ml (n = 36), lignocaine 20 mg 36) or thiopentone 100 43) on pain produced by injection propofol. One hundred and fifteen ASA 1 2 patients scheduled for minor surgery were studied using a randomised, design. Thiopentone more effective than in reducing incidence propofol (p < 0.03).
Abstract Background Many patients present in primary care with lower bowel symptoms, but significant disease (SBD), comprising colorectal cancer (CRC), advanced adenoma (AA), or inflammatory (IBD), is uncommon. Quantitative faecal immunochemical tests for haemoglobin (FIT), which examine concentrations (f-Hb), assist deciding who would benefit from colonoscopy. Incorporation of additional variables an individual risk-score might improve this approach. We investigated if the published f -Hb,...
Background Faecal haemoglobin concentration (f-Hb), estimated using a faecal immunochemical test, can be safely implemented in primary care to assess risk of colorectal cancer (CRC). Clinical outcomes patients presenting with symptoms lower gastrointestinal disease were examined an extensive range f-Hb thresholds decide on reassurance or referral for further investigation. Methods All who attended and submitted single specimen test the first year routine service had HM-JACKarc: from <2 ≥...
Background Quantitative faecal immunochemical tests measure haemoglobin concentration (f‐Hb), which increases in the presence of colorectal neoplasia. Objective We examined diagnostic accuracy test (FIT)in patients at increased risk cancer (CRC) attending for surveillance colonoscopy as per national guidelines. Methods A total 1103 consecutive were prospectively invited to complete a FIT before their scheduled two university hospitals 2014– 2016. F‐Hb was analysed on an OC‐Sensor io...
Abstract Objectives Faecal immunochemical tests for haemoglobin (FIT) are becoming widely used in colorectal cancer (CRC) screening and assessment of symptomatic patients. concentration (f-Hb) thresholds to guide subsequent investigation. We established the distributions f-Hb a large population by sex, age, deprivation geography. Methods Single estimates were documented all individuals participating first 18 months Scottish Bowel Screening Programme (SBoSP). The generated participants, men...
Background Current guidelines document persistent rectal bleeding as an alarm symptom in patients presenting to primary care. We studied whether a faecal immunochemical test could assist their assessment. Methods From December 2015, tests were routinely available care when assessing with new-onset bowel symptoms: general practitioners encouraged include haemoglobin concentration (f-Hb) within any referral secondary Results f-Hb ≥10 μg Hb/g faeces defined positive. The incidence of...
Abstract Aim The faecal immunochemical test (FIT) for haemoglobin (f‐Hb) helps determine the risk of colorectal cancer (CRC) and has been integrated into symptomatic referral pathways. ‘Safety netting’ advice includes considering persistent symptoms, but no published data exists on repeated FITs. We aimed to examine prevalence serial FITs in primary care CRC these patients. Method A multicentre, retrospective, observational study was conducted patients with two or more consecutive f‐Hb...
Background Faecal immunochemical tests for haemoglobin have been recommended to assist in assessment of patients presenting primary care with lower bowel symptoms. The aim was assess if, and which, additional variables might enhance this use faecal tests. Methods test analysis has a NHS Tayside investigation since December 2015. During the first year, 993 attending colonoscopy were invited complete detailed questionnaire on demographic background, symptoms, smoking status, alcohol use,...