Brendan Bebington
A5045347663- Colorectal Cancer Screening and Detection
- Colorectal Cancer Surgical Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Pelvic floor disorders treatments
- Pelvic and Acetabular Injuries
- Enhanced Recovery After Surgery
- Radiomics and Machine Learning in Medical Imaging
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- Hernia repair and management
- Global Cancer Incidence and Screening
- Diverticular Disease and Complications
- Economic and Financial Impacts of Cancer
- Health Systems, Economic Evaluations, Quality of Life
- Colorectal Cancer Treatments and Studies
- Anorectal Disease Treatments and Outcomes
- Inflammatory Bowel Disease
- Frailty in Older Adults
- Mitochondrial Function and Pathology
- Congenital Diaphragmatic Hernia Studies
- Radiation Dose and Imaging
- Nutrition and Health in Aging
- Abdominal Surgery and Complications
- Abdominal Trauma and Injuries
- Cancer-related molecular mechanisms research
Wits University Donald Gordon Medical Centre
2018-2024
Southampton General Hospital
2023
University of Southampton
2023
University of the Witwatersrand
1999-2022
Catharina Ziekenhuis
2021
Radboud University Nijmegen
2021
Helen Joseph Hospital
1999-2019
Johannesburg Hospital
2001
This document outlines the important aspects of caring for patients who have been diagnosed with advanced pelvic cancer. It is primarily aimed at those are establishing a service that adequately caters to this patient group. The relevant literature has summarized and an attempt made simplify approach management these complex cases.
Background: South Africa (SA) has the highest incidence of colorectal cancer (CRC) in Sub-Saharan (SSA). However, there is limited research on CRC recurrence and survival SA. overall are highly variable across studies. Accurate prediction patients at risk can enhance clinical expectations decisions within African population. We explored feasibility integrating statistical machine learning (ML) algorithms to achieve higher predictive performance interpretability findings. Methods: selected...
The multidisciplinary perioperative and anaesthetic management of patients undergoing pelvic exenteration is essential for good surgical outcomes. No clear guidelines have been established, there wide variation in clinical practice internationally. This consensus statement consolidates experience best collectively, systematically addresses key domains the management.The modified Delphi methodology was used to achieve from PelvEx Collaborative. process included one round online questionnaire...
Cancer is one of the foremost causes morbidity and mortality worldwide. Globally, colorectal cancer (CRC) third most diagnosed fourth important cause death. A total 70% all CRC-related deaths occur in low- middle-income countries. In Sub-Saharan Africa (SSA), estimating burden CRC difficult. Only 27 43 SSA countries have formalized registration systems; data quality variable national coverage rare.This a multidisciplinary, longitudinal cohort study started January 2016. Patients >18 years...
A resection with clear margins (R0 resection) is the most important prognostic factor in patients locally recurrent rectal cancer (LRRC). However, this achieved only 60 per cent of patients. The aim study to investigate whether addition induction chemotherapy neoadjuvant chemo(re)irradiation improves R0 rate LRRC.This multicentre, international, open-label, phase III, parallel-arms will enrol 364 resectable LRRC after previous partial or total mesorectal without synchronous distant...
Empty pelvis syndrome is a complex challenge resulting from the dead space generated by exenteration.A systematic review of reconstructive techniques to prevent empty cited inconsistent definitions and heterogeneous outcome reporting, was therefore unable make strong conclusions in favour particular strategy 1 .The severity complications escalates with more radical surgery as boundaries are pushed 2,3 guidelines proposed here will establish standardized definitions, outcomes, descriptors,...
The aim of this pilot study was to develop logistic regression (LR) and support vector machine (SVM) models that differentiate low from high risk for prolonged hospital length stay (LOS) in a South African cohort 383 colorectal cancer patients who underwent surgical resection with curative intent. Additionally, the impact 10-fold cross-validation (CV), Monte Carlo CV, bootstrap internal validation methods on performance two evaluated. median LOS 9 days, defined as greater than days...
Background: Definitive closure of fistula-in-ano poses an ongoing surgical challenge.The OVESCO OTSC ® Proctology Clip (proctology clip) purports to offer improved preservation the anal sphincter whilst at same time curing fistula by closure.Methods: A retrospective record review was conducted for patients who received proctology clip as part management in Colorectal Unit Wits Donald Gordon Medical Centre (WDGMC).Results: There were 19 cases treated with clip.All cryptoglandular origin.The...
A scarcity of local published data on colorectal cancer (CRC) postoperative complications, including ileus (POI), exists. POI is a temporary gastrointestinal (GI) state absent or reduced gastric motility shown to increase patient morbidity, prolong length-of-stay (LOS), and intensify the healthcare resource burden. The pathogenesis involves neurogenic inflammatory phase plus pharmacological component.
Brooks, A. FRCS(Eng); Bebington, B. D. FCS(SA); Lucas, S. MBChB; Oettle, G. J. FRCS(Ed) Author Information
For patients with colorectal cancer, surgical resection of the primary tumour remains best treatment option. Surgery for cancer is being performed on who would previously not have been considered as suitable candidates. It to be seen which factors influence hospital length stay (LOS) and development acute postoperative complications in South African patients.The objectives our study were determine modifiable that patients' LOS and, identify types develop.A retrospective review secondary...
The Colorectal Cancer South Africa (CRCSA) study is an observational cohort of patients with colorectal cancer (CRC) in Johannesburg, (SA). We found that the mean age at time CRC diagnosis was 56.6 years, consistent studies from SA and sub-Saharan Africa. In high-income settings, comorbidity adversely affects survival, are substantially older diagnosis. Given younger CRCSA cohort, we hypothesised may be less prevalent have little impact on survival.To determine prevalence whether overall...
Abstract Inflammatory bowel disease (IBD) has become a common global health problem as prevalence continues to rise. It is often associated with increased risk of colorectal cancer (CRC) development. Limitations in current IBD biomarker-based diagnosis hinder the accuracy early detection CRC progression. Therefore, this study, we proposed use transcription factor (TF)-based biomarkers that can potentially detect transition CRC. Various bioinformatic analysis and online database validations,...
Background: Lifestyle-related factors have been linked with risk for colorectal cancer. Data describing the relationship between lifestyle of South African patients who present cancer and their survival is sparse.Objectives: The objectives were to describe profile cancer; determine association lifestyle-related survival, compare results in private public sectors.
 Methods: A retrospective review secondary analysis information conducted. independent samples t-test Mann Whitney U test...
Colorectal surgery has developed into an established surgical subspecialty in South Africa, however there is a paucity of data regarding the epidemiology and outcomes patients with colorectal disease this country. The objective to present findings one-year audit Wits Donald Gordon Medical Centre (WDGMC) Unit specific reference indications, procedures patient outcomes.Patient files from December 2016 November 2017 were included retrospective analysis. Mann-Whitney U test was used analyse...
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