A5004669867- Chronic Kidney Disease and Diabetes
- Organ Transplantation Techniques and Outcomes
- Dialysis and Renal Disease Management
- HIV-related health complications and treatments
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Renal Transplantation Outcomes and Treatments
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Blood Pressure and Hypertension Studies
- Global Maternal and Child Health
- Renal Diseases and Glomerulopathies
- Sodium Intake and Health
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Pneumocystis jirovecii pneumonia detection and treatment
- Birth, Development, and Health
- Healthcare cost, quality, practices
- Genetic Associations and Epidemiology
- HIV/AIDS Impact and Responses
- Health Systems, Economic Evaluations, Quality of Life
- Healthcare Systems and Reforms
- Global Public Health Policies and Epidemiology
- Renal and Vascular Pathologies
- Transplantation: Methods and Outcomes
Wits University Donald Gordon Medical Centre
2016-2025
University of the Witwatersrand
2016-2025
Agincourt Health and Socio-Demographic Surveillance System
2019-2025
South African Medical Research Council
2025
Zero to Three
2024
Karolinska University Hospital
2023
Council for Scientific and Industrial Research
2023
Karolinska Institutet
2023
Intermountain Medical Center
2023
African Institute of Biomedical Science and Technology
2023
HIV-positive individuals are at increased risk for kidney disease, including HIV-associated nephropathy, noncollapsing focal segmental glomerulosclerosis, immune-complex and comorbid as well injury resulting from prolonged exposure to antiretroviral therapy or opportunistic infections. Clinical guidelines disease prevention treatment in largely extrapolated studies the general population, do not fully incorporate existing knowledge of unique HIV-related pathways genetic factors that...
BackgroundRapid epidemiological health transitions occurring in vulnerable populations Africa that have an existing burden of infectious and non-communicable diseases predict increased risk consequent prevalence kidney disease. However, few studies characterised the true damage associated factors Africans. We investigated markers for known rural urban settings sub-Saharan Africa.MethodsIn this cross-sectional population study (Africa Wits-International Network Demographic Evaluation...
BackgroundThe burden of kidney disease in many African countries is unknown. Equations used to estimate function from serum creatinine have limited regional validation. We sought determine the most accurate way measure and thus prevalence impaired populations.MethodsWe measured creatinine, cystatin C, glomerular filtration rate (GFR) using slope-intercept method for iohexol plasma clearance (mGFR) population cohorts Malawi, Uganda, South Africa. compared performance C-based estimating...
<h2>Summary</h2><h3>Background</h3> Observational studies have investigated the effect of serum lipids on kidney function, but these findings are limited by confounding, reverse causation and reported conflicting results. Mendelian randomization (MR) address this confounding problem. However, they been conducted mostly in European ancestry individuals. We, therefore, set out to investigate lipid traits estimated glomerular filtration rate (eGFR) based creatinine individuals African ancestry....
In this report, we summarize why the availability of cystatin C is important across a variety clinical scenarios, recent literature on when, and in whom testing should be considered, how nephrologists can take practical steps to incorporate into their practice.
Tenofovir disoproxil fumarate (TDF, commonly termed ‘tenofovir’) is the antiretroviral most implicated in antiretroviral-induced nephrotoxicity. As patients on successful therapy (ART) age, their risk for developing renal disease may increase part because of ART itself, but more importantly, HIV-associated and non-HIV-associated comorbidity. Therefore, clinicians need an approach to managing people TDF. TDF as a cause acute kidney injury (AKI) or chronic (CKD) uncommon, should actively...
Objectives To determine the prevalence of multimorbidity, to identify which chronic conditions cluster together and factors associated with a greater risk for multimorbidity in sub-Saharan Africa (SSA). Design Cross-sectional, multicentre, population-based study. Setting Six urban rural communities four African countries. Participants Men (n=4808) women (n=5892) between ages 40 60 years from AWI-Gen Measures Sociodemographic anthropometric data, as defined by presence two or more following...
Globally, the World Health Organization ranks chronic kidney disease (CKD) as one of top 10 causes mortality. In South Africa, where noncommunicable diseases have become leading mortality, true population prevalence CKD is unknown and associated risk factors remain understudied. This study aimed to describe dysfunction in a community from North West province Africa.
Multiple perinatal and early life risk factors have been implicated in the development of hypertension. The BT20 (Birth to Twenty Plus) cohort urban Soweto, South Africa, previously showed a prevalence elevated blood pressure (EBP) that ranged from 22.4% at 5 years age 34.9% 18 age. We sought determine EBP 23 within this whether could be linked any maternal childhood adolescent trajectories. Blood anthropometric measurements were completed on participants aged (n=1540; 49% men). Early...
Abstract Background Hypertension is an important public health priority with a high prevalence in Africa. It also independent risk factor for kidney outcomes. We aimed to identify potential proteins and pathways involved hypertension-associated albuminuria by assessing urinary proteomic profiles black South African participants combined hypertension compared those who have neither condition. Methods The study included 24 cases both 49 control had Protein was extracted from urine samples...
Kidney function parameters including estimated glomerular filtration rate (eGFR) and urine albumin excretion are commonly used to diagnose chronic kidney disease (CKD). However, these relatively insensitive, limiting their utility for screening early detection of disease. Studies have suggested that urinary proteomic profiles differ by eGFR stage, offering potential insights into pathogenesis alongside opportunities increase the sensitivity current testing strategies. In this study, we...
South Africa is a country with two distinct health sectors, which are both characterised by inequalities. Within this context, patients end stage renal disease face unique and sometimes impenetrable barriers to accessing dialysis. There number of reasons for situation. These include: the African government's endorsement discordant, unequal policies, disadvantage most vulnerable; lack robust national guidelines; divisive rationing practices, ad hoc place burden responsibility dialysis on...
Transplant a liver from an HIV-positive mother to her HIV-negative child save the child's life.A unique case of living donor transplantation in South Africa. Two aspects this are ground-breaking. First, it involves donation by someone who is and second controlled transplant organ into recipient, with potential prevent infection recipient.Standard surgical procedure for at our centre was followed. HIV-prophylaxis administered preoperatively. Extensive, ultrasensitive HIV testing, over above...
Chronic kidney disease (CKD) is a substantial cause of morbidity and mortality worldwide with disproportionate effects in sub-Saharan Africa (SSA). The optimal methods to estimate glomerular filtration rate (GFR) therefore determine the presence CKD SSA are uncertain. We plan measure iohexol excretion accurately GFR Malawi, South Uganda. will then assess performance existing equations whether modified equation can better improve estimation Africa.The African Research on Kidney Disease (ARK)...
Background: South Africa (SA) has the highest incidence of colorectal cancer (CRC) in Sub-Saharan (SSA). However, there is limited research on CRC recurrence and survival SA. overall are highly variable across studies. Accurate prediction patients at risk can enhance clinical expectations decisions within African population. We explored feasibility integrating statistical machine learning (ML) algorithms to achieve higher predictive performance interpretability findings. Methods: selected...
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