Rory Kennelly
A5066027253- Colorectal Cancer Screening and Detection
- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Anorectal Disease Treatments and Outcomes
- Appendicitis Diagnosis and Management
- Diverticular Disease and Complications
- COVID-19 and healthcare impacts
- Intraperitoneal and Appendiceal Malignancies
- Cardiac, Anesthesia and Surgical Outcomes
- Minimally Invasive Surgical Techniques
- Cancer Genomics and Diagnostics
- Inflammatory Biomarkers in Disease Prognosis
- Inflammatory Bowel Disease
- Estrogen and related hormone effects
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Clinical practice guidelines implementation
- Digestive system and related health
- Magnesium in Health and Disease
- Mast cells and histamine
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
St. Vincent's University Hospital
2012-2024
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2022
Institut de Virologie
2021
NIHR Birmingham Biomedical Research Centre
2021
University of Birmingham
2021
Yorkshire Cancer Research
2021
Urology Foundation
2021
Association for Cancer Surgery
2021
University College Dublin
2005-2019
Creative Research Enterprises (United States)
2016
Abstract Background The incidence of rectal cancer among adults aged less than 50 years is rising. Survival data are limited and conflicting, the oncological benefit standard neoadjuvant adjuvant therapies unclear. Methods Disease-specific outcomes patients diagnosed with undergoing surgical resection curative intent between 2006 2016 were analysed. Results A total 797 identified, whom 685 had surgery intent. Seventy younger 615 or more. Clinical stage did not differ two age groups. Patients...
To compare colorectal cancer (CRC) incidences in carriers of pathogenic variants the MMR genes PLSD and IMRC cohorts, which only former included mandatory colonoscopy surveillance for all participants.
Currently there is no guideline for the treatment of patients with Crohn's disease and high perianal fistulas. Most receive anti-TNF medication, but long-term results this expensive medication have been described, nor has its efficiency compared to surgical strategies. With study, we hope provide consensus daily clinical practice reduction in costs. This a multicentre, randomized controlled trial. Patients who are over 18 years age, newly diagnosed or recurrent active fistulas, one internal...
This first prospective observational study evaluates the impact of extended versus segmental colorectal surgery on risk metachronous cancer (CRC) in patients with Lynch syndrome, analyzing data from Prospective Syndrome Database version 5. Extended resection significantly reduced CRC path_MLH1, path_MSH2, and path_MSH6 carriers compared to resection.
Abstract Background Rectal cancer outcomes following abdominoperineal excision (APE) have been inferior to those for anterior resection, including more positive circumferential resection margins (CRMs). An erroneously conservative interpretation of APE (rather than a radical termed ‘extralevator’) has proposed as the cause. In this multicentre study, factors contributing CRM positivity were examined according its original description. Methods Data collected from five hospital databases up...
At least a third of patients with colorectal carcinoma who are candidate for surgery, anaemic preoperatively. Preoperative anaemia is associated increased morbidity and mortality. In general practice, little attention paid to these patients. Some will have oral iron prescribed others not. The waiting period prior elective surgery could be used optimize patients' physiological status. aim this study determine the efficacy preoperative intravenous supplementation in comparison standard...
Classical effects of oestrogen involve activation target genes after binding nuclear receptors. Oestrogenic too rapid for DNA transcription (non-genomic) are known to occur. The effect on colonic motility is unknown despite the prevalence gastrointestinal symptoms in pregnant and premenopausal women.Histologically normal colon was obtained from proximal resection margins colorectal carcinoma specimens. Circular smooth muscle strips were microdissected suspended organ baths under 1 g tension....
The molecular profile of early-onset colonic cancer is undefined. This study evaluated clinicopathological features and oncological outcomes young patients with according to microsatellite status.
Smoking can induce the onset of Crohn's disease in genetically susceptible patients and may accelerate progression severity. There is a paucity information as to patient knowledge impact smoking on progression. The aim this study was assess awareness, initiate cessation therapy monitor effectiveness an active programme with disease.All diagnosis over ten year period were identified from prospectively managed database. Details history link between collected through telephone questionnaire....
In this study of 400 patients with early-onset rectal cancer, 12.5 per cent demonstrated microsatellite instability (MSI). MSI was associated a reduced likelihood nodal positivity, an increased rate pathological complete response, and improved disease-specific survival.
We present a case of an unusual presentation rare primary cardiac tumour. There are no more than 50 previously reported cases paraganglioma in the world literature and only small proportion these involve right side heart. Diagnosis is difficult surgical management varied complex.
Management of anastomotic leakage (AL) following rectal resection has evolved with increasing use less invasive techniques. The aim this study was to review the management AL restorative cancer in a tertiary referral centre.A retrospective prospectively maintained database performed. primary outcome successful AL. secondary impact on oncological outcome.Five hundred and two resections were performed during period. incidence 9.9% (n = 50). occurred more commonly neoadjuvant chemoradiotherapy...